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Gene: SMAD2 |
Gene summary for SMAD2 |
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Gene information | Species | Human | Gene symbol | SMAD2 | Gene ID | 4087 |
Gene name | SMAD family member 2 | |
Gene Alias | JV18 | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000578 | UniProtAcc | Q15796 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4087 | SMAD2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.22e-27 | -7.62e-01 | 0.0155 |
4087 | SMAD2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.69e-06 | -5.35e-01 | -0.1808 |
4087 | SMAD2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.15e-04 | -8.75e-01 | 0.0216 |
4087 | SMAD2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.30e-12 | -7.62e-01 | -0.1207 |
4087 | SMAD2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.00e-05 | -5.68e-01 | -0.1526 |
4087 | SMAD2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.33e-20 | -5.97e-01 | -0.1464 |
4087 | SMAD2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.22e-16 | -5.56e-01 | -0.1001 |
4087 | SMAD2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.33e-07 | -5.07e-01 | -0.059 |
4087 | SMAD2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.07e-03 | -7.82e-01 | -0.1462 |
4087 | SMAD2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.35e-02 | -4.18e-01 | -0.0179 |
4087 | SMAD2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.09e-08 | -5.55e-01 | 0.096 |
4087 | SMAD2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.11e-03 | -7.23e-01 | 0.0446 |
4087 | SMAD2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.57e-03 | -8.53e-01 | 0.0451 |
4087 | SMAD2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.80e-07 | -8.35e-01 | 0.0528 |
4087 | SMAD2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.54e-02 | -6.05e-01 | -0.0177 |
4087 | SMAD2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.55e-12 | -7.17e-01 | 0.0338 |
4087 | SMAD2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.41e-28 | -7.10e-01 | 0.0674 |
4087 | SMAD2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.31e-02 | -6.32e-01 | 0.0112 |
4087 | SMAD2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.40e-02 | -8.79e-01 | 0.0397 |
4087 | SMAD2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.25e-03 | -5.26e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0009746 | Colorectum | AD | response to hexose | 73/3918 | 219/18723 | 1.20e-05 | 2.65e-04 | 73 |
GO:0009749 | Colorectum | AD | response to glucose | 71/3918 | 212/18723 | 1.31e-05 | 2.85e-04 | 71 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0009791 | Colorectum | AD | post-embryonic development | 29/3918 | 80/18723 | 1.13e-03 | 1.03e-02 | 29 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0035196 | Colorectum | AD | production of miRNAs involved in gene silencing by miRNA | 20/3918 | 52/18723 | 2.87e-03 | 2.14e-02 | 20 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414414 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
hsa043907 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa04659 | Lung | IAC | Th17 cell differentiation | 26/1053 | 108/8465 | 5.91e-04 | 5.34e-03 | 3.54e-03 | 26 |
hsa049264 | Lung | IAC | Relaxin signaling pathway | 29/1053 | 129/8465 | 9.70e-04 | 7.32e-03 | 4.86e-03 | 29 |
hsa049335 | Lung | IAC | AGE-RAGE signaling pathway in diabetic complications | 24/1053 | 100/8465 | 9.91e-04 | 7.32e-03 | 4.86e-03 | 24 |
hsa052127 | Lung | IAC | Pancreatic cancer | 19/1053 | 76/8465 | 1.95e-03 | 1.05e-02 | 7.00e-03 | 19 |
hsa052259 | Lung | IAC | Hepatocellular carcinoma | 33/1053 | 168/8465 | 4.77e-03 | 2.15e-02 | 1.43e-02 | 33 |
hsa0541516 | Lung | IAC | Diabetic cardiomyopathy | 38/1053 | 203/8465 | 6.01e-03 | 2.57e-02 | 1.71e-02 | 38 |
hsa041105 | Lung | IAC | Cell cycle | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa051422 | Lung | IAC | Chagas disease | 21/1053 | 102/8465 | 1.30e-02 | 4.57e-02 | 3.04e-02 | 21 |
hsa0520513 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0421813 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa0516617 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa0521013 | Lung | IAC | Colorectal cancer | 24/1053 | 86/8465 | 8.58e-05 | 1.21e-03 | 8.05e-04 | 24 |
hsa0414415 | Lung | IAC | Endocytosis | 51/1053 | 251/8465 | 2.25e-04 | 2.54e-03 | 1.68e-03 | 51 |
hsa0439012 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa046591 | Lung | IAC | Th17 cell differentiation | 26/1053 | 108/8465 | 5.91e-04 | 5.34e-03 | 3.54e-03 | 26 |
hsa0492612 | Lung | IAC | Relaxin signaling pathway | 29/1053 | 129/8465 | 9.70e-04 | 7.32e-03 | 4.86e-03 | 29 |
hsa0493312 | Lung | IAC | AGE-RAGE signaling pathway in diabetic complications | 24/1053 | 100/8465 | 9.91e-04 | 7.32e-03 | 4.86e-03 | 24 |
hsa0521212 | Lung | IAC | Pancreatic cancer | 19/1053 | 76/8465 | 1.95e-03 | 1.05e-02 | 7.00e-03 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMAD2 | SNV | Missense_Mutation | c.433N>T | p.Ala145Ser | p.A145S | Q15796 | protein_coding | tolerated(0.33) | possibly_damaging(0.51) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
SMAD2 | SNV | Missense_Mutation | c.1324N>G | p.Leu442Val | p.L442V | Q15796 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SMAD2 | SNV | Missense_Mutation | novel | c.159N>T | p.Lys53Asn | p.K53N | Q15796 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMAD2 | SNV | Missense_Mutation | c.933C>G | p.Phe311Leu | p.F311L | Q15796 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SMAD2 | SNV | Missense_Mutation | c.1067N>G | p.Phe356Cys | p.F356C | Q15796 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-E2-A152-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | PD | |
SMAD2 | insertion | Frame_Shift_Ins | novel | c.430_431insTTTTCTTTTGC | p.Lys144IlefsTer23 | p.K144Ifs*23 | Q15796 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
SMAD2 | SNV | Missense_Mutation | novel | c.163N>G | p.Thr55Ala | p.T55A | Q15796 | protein_coding | tolerated(0.14) | possibly_damaging(0.491) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SMAD2 | SNV | Missense_Mutation | c.962G>A | p.Arg321Gln | p.R321Q | Q15796 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
SMAD2 | SNV | Missense_Mutation | c.1283G>A | p.Arg428Lys | p.R428K | Q15796 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SMAD2 | SNV | Missense_Mutation | c.914N>A | p.Pro305Gln | p.P305Q | Q15796 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | GERANIIN | GERANIIN | 26169124 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | DEMETHOXYCURCUMIN | DEMETHOXYCURCUMIN | 23145932 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | ATRA | TRETINOIN | 15799023 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | BLEOMYCIN | BLEOMYCIN | 17274978 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | BISDEMETHOXYCURCUMIN | BISDEMETHOXYCURCUMIN | 23145932 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | HYDROCORTISONE | HYDROCORTISONE | 16644034 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | BLM | BLEOMYCIN | 17274978 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | AMIFOSTINE | AMIFOSTINE | 12410567 | |
4087 | SMAD2 | KINASE, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX | CURCUMIN | CURCUMIN | 23145932 |
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