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Gene: MAPK13 |
Gene summary for MAPK13 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MAPK13 | Gene ID | 5603 |
Gene name | mitogen-activated protein kinase 13 | |
Gene Alias | MAPK 13 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RD04 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5603 | MAPK13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.64e-07 | 3.13e-01 | 0.0155 |
5603 | MAPK13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.42e-19 | 8.96e-01 | -0.1808 |
5603 | MAPK13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.60e-17 | 8.76e-01 | -0.0811 |
5603 | MAPK13 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.98e-16 | 7.67e-01 | -0.1088 |
5603 | MAPK13 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.52e-39 | 9.71e-01 | -0.1954 |
5603 | MAPK13 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.07e-11 | 1.31e+00 | -0.2602 |
5603 | MAPK13 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.42e-09 | 1.10e+00 | -0.2196 |
5603 | MAPK13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.00e-11 | 6.60e-01 | -0.1207 |
5603 | MAPK13 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.30e-17 | 7.64e-01 | -0.1526 |
5603 | MAPK13 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.46e-31 | 8.50e-01 | -0.1464 |
5603 | MAPK13 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.23e-17 | 6.38e-01 | -0.1001 |
5603 | MAPK13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.19e-28 | 1.08e+00 | -0.059 |
5603 | MAPK13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.32e-09 | 8.79e-01 | -0.1706 |
5603 | MAPK13 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.42e-11 | 9.48e-01 | -0.2061 |
5603 | MAPK13 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.19e-09 | 6.05e-01 | -0.0842 |
5603 | MAPK13 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.83e-03 | 4.07e-01 | -0.0179 |
5603 | MAPK13 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.38e-17 | 7.36e-01 | 0.096 |
5603 | MAPK13 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.76e-04 | 6.73e-01 | 0.0446 |
5603 | MAPK13 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.87e-07 | 6.68e-01 | 0.0528 |
5603 | MAPK13 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.35e-10 | 9.42e-01 | 0.0131 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0042542 | Colorectum | AD | response to hydrogen peroxide | 52/3918 | 146/18723 | 2.83e-05 | 5.30e-04 | 52 |
GO:0071322 | Colorectum | AD | cellular response to carbohydrate stimulus | 56/3918 | 163/18723 | 4.61e-05 | 7.97e-04 | 56 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0034614 | Colorectum | AD | cellular response to reactive oxygen species | 50/3918 | 155/18723 | 6.25e-04 | 6.49e-03 | 50 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00003021 | Colorectum | SER | response to reactive oxygen species | 65/2897 | 222/18723 | 1.21e-07 | 7.29e-06 | 65 |
GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
GO:00345991 | Colorectum | SER | cellular response to oxidative stress | 73/2897 | 288/18723 | 8.52e-06 | 2.86e-04 | 73 |
GO:00425421 | Colorectum | SER | response to hydrogen peroxide | 42/2897 | 146/18723 | 3.10e-05 | 8.27e-04 | 42 |
GO:00346141 | Colorectum | SER | cellular response to reactive oxygen species | 41/2897 | 155/18723 | 2.89e-04 | 4.74e-03 | 41 |
GO:00097431 | Colorectum | SER | response to carbohydrate | 60/2897 | 253/18723 | 3.66e-04 | 5.67e-03 | 60 |
GO:0071243 | Colorectum | SER | cellular response to arsenic-containing substance | 9/2897 | 20/18723 | 1.66e-03 | 1.72e-02 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049328 | Colorectum | FAP | Non-alcoholic fatty liver disease | 54/1404 | 155/8465 | 1.98e-08 | 6.20e-07 | 3.77e-07 | 54 |
hsa051308 | Colorectum | FAP | Pathogenic Escherichia coli infection | 62/1404 | 197/8465 | 1.37e-07 | 3.08e-06 | 1.87e-06 | 62 |
hsa047148 | Colorectum | FAP | Thermogenesis | 70/1404 | 232/8465 | 1.38e-07 | 3.08e-06 | 1.87e-06 | 70 |
hsa050228 | Colorectum | FAP | Pathways of neurodegeneration - multiple diseases | 117/1404 | 476/8465 | 2.81e-06 | 4.47e-05 | 2.72e-05 | 117 |
hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa051356 | Colorectum | FAP | Yersinia infection | 43/1404 | 137/8465 | 1.21e-05 | 1.62e-04 | 9.86e-05 | 43 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa051328 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa046706 | Colorectum | FAP | Leukocyte transendothelial migration | 37/1404 | 114/8465 | 2.12e-05 | 2.53e-04 | 1.54e-04 | 37 |
hsa047226 | Colorectum | FAP | Neurotrophin signaling pathway | 38/1404 | 119/8465 | 2.49e-05 | 2.78e-04 | 1.69e-04 | 38 |
hsa052056 | Colorectum | FAP | Proteoglycans in cancer | 57/1404 | 205/8465 | 3.05e-05 | 3.29e-04 | 2.00e-04 | 57 |
hsa050208 | Colorectum | FAP | Prion disease | 68/1404 | 273/8465 | 2.33e-04 | 1.94e-03 | 1.18e-03 | 68 |
hsa042184 | Colorectum | FAP | Cellular senescence | 42/1404 | 156/8465 | 6.79e-04 | 4.63e-03 | 2.82e-03 | 42 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa054176 | Colorectum | FAP | Lipid and atherosclerosis | 54/1404 | 215/8465 | 8.04e-04 | 5.14e-03 | 3.13e-03 | 54 |
hsa049352 | Colorectum | FAP | Growth hormone synthesis, secretion and action | 34/1404 | 120/8465 | 8.12e-04 | 5.14e-03 | 3.13e-03 | 34 |
hsa049126 | Colorectum | FAP | GnRH signaling pathway | 28/1404 | 93/8465 | 8.16e-04 | 5.14e-03 | 3.13e-03 | 28 |
hsa040714 | Colorectum | FAP | Sphingolipid signaling pathway | 34/1404 | 121/8465 | 9.53e-04 | 5.22e-03 | 3.17e-03 | 34 |
hsa051636 | Colorectum | FAP | Human cytomegalovirus infection | 55/1404 | 225/8465 | 1.42e-03 | 7.67e-03 | 4.67e-03 | 55 |
hsa051706 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAPK13 | SNV | Missense_Mutation | c.943G>A | p.Glu315Lys | p.E315K | O15264 | protein_coding | tolerated(0.12) | benign(0.04) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
MAPK13 | insertion | Nonsense_Mutation | novel | c.512_513insCCCCTAAGA | p.Leu171_Ala172insProTerGlu | p.L171_A172insP*E | O15264 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
MAPK13 | SNV | Missense_Mutation | rs141413397 | c.1075C>T | p.Arg359Cys | p.R359C | O15264 | protein_coding | deleterious(0) | possibly_damaging(0.724) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAPK13 | SNV | Missense_Mutation | c.943N>A | p.Glu315Lys | p.E315K | O15264 | protein_coding | tolerated(0.12) | benign(0.04) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
MAPK13 | SNV | Missense_Mutation | rs762484290 | c.574N>A | p.Glu192Lys | p.E192K | O15264 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
MAPK13 | SNV | Missense_Mutation | c.885N>C | p.Lys295Asn | p.K295N | O15264 | protein_coding | tolerated(0.08) | benign(0.081) | TCGA-AA-3812-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MAPK13 | SNV | Missense_Mutation | c.155N>T | p.Ala52Val | p.A52V | O15264 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAPK13 | SNV | Missense_Mutation | c.593N>C | p.Met198Thr | p.M198T | O15264 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAPK13 | deletion | Frame_Shift_Del | c.569delN | p.Glu192ArgfsTer2 | p.E192Rfs*2 | O15264 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MAPK13 | SNV | Missense_Mutation | novel | c.445N>G | p.Arg149Gly | p.R149G | O15264 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | OPHIOBOLIN O | OPHIOBOLIN O | 22130129 | |
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565859 | PF-03715455 | |
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | SEMAPIMOD | SEMAPIMOD | ||
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | SNS-314 | SNS-314 | ||
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | ARRY-797 | ARRY-797 | ||
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | MILTIRONE | MILTIRONE | 26339922 | |
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | TAMATINIB | R-406 | ||
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | DIHYDROTANSHINONE I | DIHYDROTANSHINONE I | 26339922 | |
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | VX-702 | VX-702 | ||
5603 | MAPK13 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | DORAMAPIMOD | DORAMAPIMOD |
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