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Gene: HLA-DMA |
Gene summary for HLA-DMA |
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Gene information | Species | Human | Gene symbol | HLA-DMA | Gene ID | 3108 |
Gene name | major histocompatibility complex, class II, DM alpha | |
Gene Alias | D6S222E | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q31604 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3108 | HLA-DMA | CCI_1 | Human | Cervix | CC | 1.12e-04 | -6.48e-01 | 0.528 |
3108 | HLA-DMA | CCI_3 | Human | Cervix | CC | 7.76e-05 | -5.96e-01 | 0.516 |
3108 | HLA-DMA | CCII_1 | Human | Cervix | CC | 3.65e-15 | -6.89e-01 | 0.3249 |
3108 | HLA-DMA | Tumor | Human | Cervix | CC | 6.92e-08 | -2.66e-01 | 0.1241 |
3108 | HLA-DMA | sample3 | Human | Cervix | CC | 8.65e-10 | -3.15e-01 | 0.1387 |
3108 | HLA-DMA | H2 | Human | Cervix | HSIL_HPV | 1.27e-03 | -1.70e-01 | 0.0632 |
3108 | HLA-DMA | L1 | Human | Cervix | CC | 1.33e-05 | -4.84e-01 | 0.0802 |
3108 | HLA-DMA | T1 | Human | Cervix | CC | 3.34e-02 | 2.17e-01 | 0.0918 |
3108 | HLA-DMA | T3 | Human | Cervix | CC | 1.11e-10 | -3.17e-01 | 0.1389 |
3108 | HLA-DMA | EEC-subject4 | Human | Endometrium | EEC | 9.87e-04 | 2.52e-01 | -0.2571 |
3108 | HLA-DMA | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.41e-14 | 6.00e-01 | -0.1869 |
3108 | HLA-DMA | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.80e-12 | 5.31e-01 | -0.1875 |
3108 | HLA-DMA | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.83e-13 | 4.48e-01 | -0.1883 |
3108 | HLA-DMA | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.17e-05 | -4.34e-02 | -0.1934 |
3108 | HLA-DMA | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.42e-08 | 8.68e-02 | -0.1917 |
3108 | HLA-DMA | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.72e-05 | 1.71e-01 | -0.1916 |
3108 | HLA-DMA | LZE8T | Human | Esophagus | ESCC | 2.33e-31 | 1.38e+00 | 0.067 |
3108 | HLA-DMA | LZE24T | Human | Esophagus | ESCC | 4.16e-04 | 3.24e-01 | 0.0596 |
3108 | HLA-DMA | LZE6T | Human | Esophagus | ESCC | 2.51e-23 | 1.55e+00 | 0.0845 |
3108 | HLA-DMA | P1T-E | Human | Esophagus | ESCC | 2.69e-02 | 1.10e+00 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:000247810 | Cervix | CC | antigen processing and presentation of exogenous peptide antigen | 18/2311 | 38/18723 | 1.20e-07 | 6.06e-06 | 18 |
GO:004800210 | Cervix | CC | antigen processing and presentation of peptide antigen | 24/2311 | 62/18723 | 1.21e-07 | 6.07e-06 | 24 |
GO:001988410 | Cervix | CC | antigen processing and presentation of exogenous antigen | 20/2311 | 47/18723 | 2.18e-07 | 9.57e-06 | 20 |
GO:00023968 | Cervix | CC | MHC protein complex assembly | 12/2311 | 19/18723 | 2.65e-07 | 1.12e-05 | 12 |
GO:001988210 | Cervix | CC | antigen processing and presentation | 32/2311 | 106/18723 | 8.61e-07 | 3.08e-05 | 32 |
GO:00025018 | Cervix | CC | peptide antigen assembly with MHC protein complex | 11/2311 | 18/18723 | 1.37e-06 | 4.55e-05 | 11 |
GO:00025048 | Cervix | CC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 16/2311 | 36/18723 | 1.76e-06 | 5.76e-05 | 16 |
GO:00023998 | Cervix | CC | MHC class II protein complex assembly | 10/2311 | 16/18723 | 3.18e-06 | 8.77e-05 | 10 |
GO:00025038 | Cervix | CC | peptide antigen assembly with MHC class II protein complex | 10/2311 | 16/18723 | 3.18e-06 | 8.77e-05 | 10 |
GO:00198869 | Cervix | CC | antigen processing and presentation of exogenous peptide antigen via MHC class II | 14/2311 | 30/18723 | 3.85e-06 | 1.01e-04 | 14 |
GO:00024958 | Cervix | CC | antigen processing and presentation of peptide antigen via MHC class II | 15/2311 | 34/18723 | 4.16e-06 | 1.08e-04 | 15 |
GO:00224099 | Cervix | CC | positive regulation of cell-cell adhesion | 61/2311 | 284/18723 | 9.30e-06 | 2.11e-04 | 61 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:00508708 | Cervix | CC | positive regulation of T cell activation | 49/2311 | 216/18723 | 1.51e-05 | 2.97e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05145110 | Oral cavity | OSCC | Toxoplasmosis | 75/3704 | 112/8465 | 5.28e-07 | 3.16e-06 | 1.61e-06 | 75 |
hsa0515211 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa04145113 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0465913 | Oral cavity | OSCC | Th17 cell differentiation | 65/3704 | 108/8465 | 4.02e-04 | 1.25e-03 | 6.35e-04 | 65 |
hsa05416113 | Oral cavity | OSCC | Viral myocarditis | 39/3704 | 60/8465 | 7.13e-04 | 2.09e-03 | 1.07e-03 | 39 |
hsa0532319 | Oral cavity | OSCC | Rheumatoid arthritis | 56/3704 | 93/8465 | 9.72e-04 | 2.76e-03 | 1.40e-03 | 56 |
hsa04612113 | Oral cavity | OSCC | Antigen processing and presentation | 47/3704 | 78/8465 | 2.37e-03 | 6.35e-03 | 3.23e-03 | 47 |
hsa0465811 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa0516929 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
hsa05166210 | Oral cavity | LP | Human T-cell leukemia virus 1 infection | 100/2418 | 222/8465 | 8.94e-08 | 1.29e-06 | 8.35e-07 | 100 |
hsa0414529 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516424 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa05416210 | Oral cavity | LP | Viral myocarditis | 32/2418 | 60/8465 | 4.55e-05 | 2.91e-04 | 1.88e-04 | 32 |
hsa0514524 | Oral cavity | LP | Toxoplasmosis | 51/2418 | 112/8465 | 8.99e-05 | 5.54e-04 | 3.57e-04 | 51 |
hsa04612210 | Oral cavity | LP | Antigen processing and presentation | 37/2418 | 78/8465 | 2.98e-04 | 1.60e-03 | 1.03e-03 | 37 |
hsa0515221 | Oral cavity | LP | Tuberculosis | 65/2418 | 180/8465 | 1.60e-02 | 4.92e-02 | 3.17e-02 | 65 |
hsa0516936 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
hsa0516638 | Oral cavity | LP | Human T-cell leukemia virus 1 infection | 100/2418 | 222/8465 | 8.94e-08 | 1.29e-06 | 8.35e-07 | 100 |
hsa0414536 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516434 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Breast | DCIS |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Breast | Healthy |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Breast | IDC |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Cervix | ADJ |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Cervix | CC |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Cervix | Healthy |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Cervix | Precancer |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | CRC | AD |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | CRC | ADJ |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | CRC | SER |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Endometrium | ADJ |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Endometrium | AEH |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Endometrium | EEC |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Endometrium | Healthy |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | HNSCC | ADJ |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | HNSCC | Healthy |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | HNSCC | OSCC |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | HNSCC | Precancer |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Liver | HCC |
HLA-DMA | CD4 | HLA-DMA_CD4 | MHC-II | Liver | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HLA-DMA | SNV | Missense_Mutation | novel | c.631N>C | p.Tyr211His | p.Y211H | P28067 | protein_coding | tolerated(0.15) | benign(0.023) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
HLA-DMA | SNV | Missense_Mutation | rs368160706 | c.214G>A | p.Asp72Asn | p.D72N | P28067 | protein_coding | tolerated(0.25) | benign(0.026) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HLA-DMA | SNV | Missense_Mutation | novel | c.29C>T | p.Ala10Val | p.A10V | P28067 | protein_coding | tolerated_low_confidence(0.25) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HLA-DMA | SNV | Missense_Mutation | c.653T>C | p.Val218Ala | p.V218A | P28067 | protein_coding | deleterious(0.01) | benign(0.427) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
HLA-DMA | SNV | Missense_Mutation | novel | c.326T>A | p.Ile109Asn | p.I109N | P28067 | protein_coding | deleterious(0.03) | possibly_damaging(0.849) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DMA | SNV | Missense_Mutation | rs779711764 | c.763N>T | p.Arg255Trp | p.R255W | P28067 | protein_coding | deleterious(0.02) | possibly_damaging(0.791) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DMA | SNV | Missense_Mutation | rs768509769 | c.736N>A | p.Val246Met | p.V246M | P28067 | protein_coding | tolerated(0.06) | benign(0.074) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HLA-DMA | insertion | Frame_Shift_Ins | novel | c.549_550insCAGAA | p.Phe184GlnfsTer9 | p.F184Qfs*9 | P28067 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HLA-DMA | insertion | Frame_Shift_Ins | novel | c.326_327insGAGAA | p.Ile109MetfsTer6 | p.I109Mfs*6 | P28067 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HLA-DMA | SNV | Missense_Mutation | rs779711764 | c.763N>T | p.Arg255Trp | p.R255W | P28067 | protein_coding | deleterious(0.02) | possibly_damaging(0.791) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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