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Gene: GADD45B |
Gene summary for GADD45B |
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Gene information | Species | Human | Gene symbol | GADD45B | Gene ID | 4616 |
Gene name | growth arrest and DNA damage inducible beta | |
Gene Alias | GADD45BETA | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O75293 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4616 | GADD45B | GSM4909281 | Human | Breast | IDC | 3.30e-06 | -4.79e-01 | 0.21 |
4616 | GADD45B | GSM4909285 | Human | Breast | IDC | 1.03e-22 | -8.42e-01 | 0.21 |
4616 | GADD45B | GSM4909286 | Human | Breast | IDC | 8.44e-17 | -7.42e-01 | 0.1081 |
4616 | GADD45B | GSM4909288 | Human | Breast | IDC | 7.74e-07 | -7.01e-01 | 0.0988 |
4616 | GADD45B | GSM4909289 | Human | Breast | IDC | 1.77e-02 | -6.71e-01 | 0.1064 |
4616 | GADD45B | GSM4909290 | Human | Breast | IDC | 9.46e-23 | -8.68e-01 | 0.2096 |
4616 | GADD45B | GSM4909293 | Human | Breast | IDC | 9.06e-17 | -6.99e-01 | 0.1581 |
4616 | GADD45B | GSM4909294 | Human | Breast | IDC | 8.44e-17 | -7.39e-01 | 0.2022 |
4616 | GADD45B | GSM4909296 | Human | Breast | IDC | 4.74e-02 | -3.54e-01 | 0.1524 |
4616 | GADD45B | GSM4909297 | Human | Breast | IDC | 6.44e-04 | -2.41e-01 | 0.1517 |
4616 | GADD45B | GSM4909298 | Human | Breast | IDC | 5.37e-13 | -5.69e-01 | 0.1551 |
4616 | GADD45B | GSM4909302 | Human | Breast | IDC | 4.99e-11 | -5.65e-01 | 0.1545 |
4616 | GADD45B | GSM4909304 | Human | Breast | IDC | 5.54e-11 | -5.93e-01 | 0.1636 |
4616 | GADD45B | GSM4909306 | Human | Breast | IDC | 7.89e-04 | 3.64e-02 | 0.1564 |
4616 | GADD45B | GSM4909307 | Human | Breast | IDC | 3.04e-08 | -6.01e-01 | 0.1569 |
4616 | GADD45B | GSM4909308 | Human | Breast | IDC | 1.05e-02 | 2.79e-01 | 0.158 |
4616 | GADD45B | GSM4909309 | Human | Breast | IDC | 7.98e-03 | -3.78e-01 | 0.0483 |
4616 | GADD45B | GSM4909311 | Human | Breast | IDC | 1.03e-35 | -8.86e-01 | 0.1534 |
4616 | GADD45B | GSM4909312 | Human | Breast | IDC | 1.67e-06 | -4.89e-01 | 0.1552 |
4616 | GADD45B | GSM4909315 | Human | Breast | IDC | 1.35e-11 | -5.97e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
GO:00459369 | Breast | IDC | negative regulation of phosphate metabolic process | 53/1434 | 441/18723 | 7.21e-04 | 8.79e-03 | 53 |
GO:00105639 | Breast | IDC | negative regulation of phosphorus metabolic process | 53/1434 | 442/18723 | 7.60e-04 | 9.25e-03 | 53 |
GO:00064699 | Breast | IDC | negative regulation of protein kinase activity | 27/1434 | 212/18723 | 6.30e-03 | 4.47e-02 | 27 |
GO:005134824 | Breast | DCIS | negative regulation of transferase activity | 39/1390 | 268/18723 | 4.02e-05 | 8.60e-04 | 39 |
GO:004593614 | Breast | DCIS | negative regulation of phosphate metabolic process | 53/1390 | 441/18723 | 3.48e-04 | 4.96e-03 | 53 |
GO:001056314 | Breast | DCIS | negative regulation of phosphorus metabolic process | 53/1390 | 442/18723 | 3.68e-04 | 5.18e-03 | 53 |
GO:000646913 | Breast | DCIS | negative regulation of protein kinase activity | 27/1390 | 212/18723 | 4.18e-03 | 3.30e-02 | 27 |
GO:00423269 | Breast | DCIS | negative regulation of phosphorylation | 43/1390 | 385/18723 | 4.78e-03 | 3.62e-02 | 43 |
GO:00019339 | Breast | DCIS | negative regulation of protein phosphorylation | 39/1390 | 342/18723 | 4.94e-03 | 3.71e-02 | 39 |
GO:00336738 | Breast | DCIS | negative regulation of kinase activity | 29/1390 | 237/18723 | 5.44e-03 | 3.99e-02 | 29 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0522211 | Liver | HCC | Small cell lung cancer | 57/4020 | 92/8465 | 3.54e-03 | 1.12e-02 | 6.22e-03 | 57 |
hsa0522311 | Liver | HCC | Non-small cell lung cancer | 46/4020 | 72/8465 | 3.61e-03 | 1.12e-02 | 6.22e-03 | 46 |
hsa0521411 | Liver | HCC | Glioma | 47/4020 | 75/8465 | 5.67e-03 | 1.62e-02 | 9.02e-03 | 47 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa042104 | Liver | Cyst | Apoptosis | 13/339 | 136/8465 | 3.07e-03 | 2.41e-02 | 1.99e-02 | 13 |
hsa0421842 | Liver | Cyst | Cellular senescence | 14/339 | 156/8465 | 3.86e-03 | 2.85e-02 | 2.35e-02 | 14 |
hsa042105 | Liver | Cyst | Apoptosis | 13/339 | 136/8465 | 3.07e-03 | 2.41e-02 | 1.99e-02 | 13 |
hsa0421852 | Liver | Cyst | Cellular senescence | 14/339 | 156/8465 | 3.86e-03 | 2.85e-02 | 2.35e-02 | 14 |
hsa042188 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa052108 | Lung | IAC | Colorectal cancer | 24/1053 | 86/8465 | 8.58e-05 | 1.21e-03 | 8.05e-04 | 24 |
hsa052139 | Lung | IAC | Endometrial cancer | 18/1053 | 58/8465 | 1.50e-04 | 1.87e-03 | 1.24e-03 | 18 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa042107 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa052168 | Lung | IAC | Thyroid cancer | 12/1053 | 37/8465 | 1.21e-03 | 8.24e-03 | 5.47e-03 | 12 |
hsa040686 | Lung | IAC | FoxO signaling pathway | 29/1053 | 131/8465 | 1.25e-03 | 8.24e-03 | 5.47e-03 | 29 |
hsa052225 | Lung | IAC | Small cell lung cancer | 22/1053 | 92/8465 | 1.66e-03 | 9.66e-03 | 6.41e-03 | 22 |
hsa0516916 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa052146 | Lung | IAC | Glioma | 18/1053 | 75/8465 | 4.07e-03 | 1.94e-02 | 1.29e-02 | 18 |
hsa052209 | Lung | IAC | Chronic myeloid leukemia | 18/1053 | 76/8465 | 4.73e-03 | 2.15e-02 | 1.43e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45B | SNV | Missense_Mutation | c.103N>T | p.Arg35Cys | p.R35C | O75293 | protein_coding | tolerated(0.66) | benign(0.003) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
GADD45B | SNV | Missense_Mutation | c.187N>A | p.Glu63Lys | p.E63K | O75293 | protein_coding | tolerated(0.07) | benign(0.102) | TCGA-93-A4JP-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD | |
GADD45B | SNV | Missense_Mutation | c.376N>T | p.His126Tyr | p.H126Y | O75293 | protein_coding | tolerated(0.53) | benign(0.057) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GADD45B | SNV | Missense_Mutation | c.189N>C | p.Glu63Asp | p.E63D | O75293 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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