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Gene: FADD |
Gene summary for FADD |
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Gene information | Species | Human | Gene symbol | FADD | Gene ID | 8772 |
Gene name | Fas associated via death domain | |
Gene Alias | GIG3 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q13158 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8772 | FADD | LZE4T | Human | Esophagus | ESCC | 3.08e-18 | 5.80e-01 | 0.0811 |
8772 | FADD | LZE5T | Human | Esophagus | ESCC | 9.93e-08 | 5.04e-01 | 0.0514 |
8772 | FADD | LZE8T | Human | Esophagus | ESCC | 8.22e-06 | 1.76e-01 | 0.067 |
8772 | FADD | LZE20T | Human | Esophagus | ESCC | 1.47e-17 | 6.62e-01 | 0.0662 |
8772 | FADD | LZE21D1 | Human | Esophagus | HGIN | 1.77e-03 | 6.20e-01 | 0.0632 |
8772 | FADD | LZE22T | Human | Esophagus | ESCC | 6.33e-08 | 9.59e-01 | 0.068 |
8772 | FADD | LZE24T | Human | Esophagus | ESCC | 9.82e-10 | 2.66e-01 | 0.0596 |
8772 | FADD | LZE21T | Human | Esophagus | ESCC | 1.08e-11 | 1.22e+00 | 0.0655 |
8772 | FADD | P1T-E | Human | Esophagus | ESCC | 1.45e-24 | 1.11e+00 | 0.0875 |
8772 | FADD | P2T-E | Human | Esophagus | ESCC | 2.36e-108 | 2.14e+00 | 0.1177 |
8772 | FADD | P4T-E | Human | Esophagus | ESCC | 3.61e-21 | 5.62e-01 | 0.1323 |
8772 | FADD | P5T-E | Human | Esophagus | ESCC | 2.72e-27 | 5.36e-01 | 0.1327 |
8772 | FADD | P8T-E | Human | Esophagus | ESCC | 8.52e-76 | 1.47e+00 | 0.0889 |
8772 | FADD | P9T-E | Human | Esophagus | ESCC | 7.29e-13 | 2.63e-01 | 0.1131 |
8772 | FADD | P10T-E | Human | Esophagus | ESCC | 3.41e-09 | 1.55e-01 | 0.116 |
8772 | FADD | P11T-E | Human | Esophagus | ESCC | 6.07e-09 | 4.33e-01 | 0.1426 |
8772 | FADD | P12T-E | Human | Esophagus | ESCC | 6.68e-33 | 3.20e-01 | 0.1122 |
8772 | FADD | P15T-E | Human | Esophagus | ESCC | 6.18e-25 | 6.75e-01 | 0.1149 |
8772 | FADD | P16T-E | Human | Esophagus | ESCC | 1.77e-90 | 1.80e+00 | 0.1153 |
8772 | FADD | P17T-E | Human | Esophagus | ESCC | 5.79e-24 | 1.84e+00 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:200123327 | Esophagus | HGIN | regulation of apoptotic signaling pathway | 97/2587 | 356/18723 | 1.36e-11 | 1.57e-09 | 97 |
GO:200123519 | Esophagus | HGIN | positive regulation of apoptotic signaling pathway | 41/2587 | 126/18723 | 6.06e-08 | 3.22e-06 | 41 |
GO:200011626 | Esophagus | HGIN | regulation of cysteine-type endopeptidase activity | 63/2587 | 235/18723 | 9.71e-08 | 5.02e-06 | 63 |
GO:005254726 | Esophagus | HGIN | regulation of peptidase activity | 102/2587 | 461/18723 | 6.29e-07 | 2.72e-05 | 102 |
GO:001095225 | Esophagus | HGIN | positive regulation of peptidase activity | 53/2587 | 197/18723 | 8.70e-07 | 3.59e-05 | 53 |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:005254826 | Esophagus | HGIN | regulation of endopeptidase activity | 96/2587 | 432/18723 | 1.09e-06 | 4.30e-05 | 96 |
GO:009719126 | Esophagus | HGIN | extrinsic apoptotic signaling pathway | 56/2587 | 219/18723 | 2.48e-06 | 8.80e-05 | 56 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:007099727 | Esophagus | HGIN | neuron death | 81/2587 | 361/18723 | 5.01e-06 | 1.61e-04 | 81 |
GO:200105620 | Esophagus | HGIN | positive regulation of cysteine-type endopeptidase activity | 41/2587 | 148/18723 | 6.65e-06 | 2.07e-04 | 41 |
GO:001095020 | Esophagus | HGIN | positive regulation of endopeptidase activity | 47/2587 | 179/18723 | 7.23e-06 | 2.20e-04 | 47 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:003009927 | Esophagus | HGIN | myeloid cell differentiation | 83/2587 | 381/18723 | 1.26e-05 | 3.52e-04 | 83 |
GO:007149626 | Esophagus | HGIN | cellular response to external stimulus | 71/2587 | 320/18723 | 2.77e-05 | 7.19e-04 | 71 |
GO:004563725 | Esophagus | HGIN | regulation of myeloid cell differentiation | 49/2587 | 210/18723 | 1.28e-04 | 2.61e-03 | 49 |
GO:004873225 | Esophagus | HGIN | gland development | 88/2587 | 436/18723 | 1.34e-04 | 2.71e-03 | 88 |
GO:00027617 | Esophagus | HGIN | regulation of myeloid leukocyte differentiation | 31/2587 | 120/18723 | 3.35e-04 | 5.50e-03 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa05167210 | Oral cavity | LP | Kaposi sarcoma-associated herpesvirus infection | 84/2418 | 194/8465 | 6.66e-06 | 5.16e-05 | 3.33e-05 | 84 |
hsa0465725 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0516221 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
hsa0466822 | Oral cavity | LP | TNF signaling pathway | 49/2418 | 114/8465 | 6.51e-04 | 3.29e-03 | 2.12e-03 | 49 |
hsa0516523 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0516122 | Oral cavity | LP | Hepatitis B | 65/2418 | 162/8465 | 9.31e-04 | 4.43e-03 | 2.86e-03 | 65 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0516329 | Oral cavity | LP | Human cytomegalovirus infection | 85/2418 | 225/8465 | 1.55e-03 | 6.89e-03 | 4.45e-03 | 85 |
hsa042152 | Oral cavity | LP | Apoptosis - multiple species | 16/2418 | 32/8465 | 8.31e-03 | 3.08e-02 | 1.98e-02 | 16 |
hsa046222 | Oral cavity | LP | RIG-I-like receptor signaling pathway | 30/2418 | 71/8465 | 9.09e-03 | 3.33e-02 | 2.14e-02 | 30 |
hsa0421714 | Oral cavity | LP | Necroptosis | 59/2418 | 159/8465 | 1.15e-02 | 3.91e-02 | 2.52e-02 | 59 |
hsa046232 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa0515221 | Oral cavity | LP | Tuberculosis | 65/2418 | 180/8465 | 1.60e-02 | 4.92e-02 | 3.17e-02 | 65 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0513238 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
hsa0516936 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
hsa0516434 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa0516034 | Oral cavity | LP | Hepatitis C | 73/2418 | 157/8465 | 1.14e-06 | 1.36e-05 | 8.74e-06 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FADD | deletion | Frame_Shift_Del | novel | c.464delA | p.Asn155ThrfsTer16 | p.N155Tfs*16 | Q13158 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FADD | SNV | Missense_Mutation | novel | c.163C>A | p.Leu55Met | p.L55M | Q13158 | protein_coding | tolerated(0.06) | probably_damaging(0.995) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.404G>A | p.Arg135His | p.R135H | Q13158 | protein_coding | tolerated(0.44) | benign(0.203) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FADD | SNV | Missense_Mutation | novel | c.485N>C | p.Val162Ala | p.V162A | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FADD | SNV | Missense_Mutation | novel | c.525C>A | p.Asp175Glu | p.D175E | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | c.331N>C | p.Asp111His | p.D111H | Q13158 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FADD | insertion | Frame_Shift_Ins | novel | c.524_525insG | p.Asp175GlufsTer11 | p.D175Efs*11 | Q13158 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FADD | SNV | Missense_Mutation | novel | c.14N>C | p.Leu5Pro | p.L5P | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.404N>A | p.Arg135His | p.R135H | Q13158 | protein_coding | tolerated(0.44) | benign(0.203) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.80N>A | p.Cys27Tyr | p.C27Y | Q13158 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8772 | FADD | NA | FAS LIGAND | 11384965 |
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