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Gene: CREB3L1 |
Gene summary for CREB3L1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CREB3L1 | Gene ID | 90993 |
Gene name | cAMP responsive element binding protein 3 like 1 | |
Gene Alias | OASIS | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B2RA75 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90993 | CREB3L1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.43e-02 | 1.83e-01 | 0.0155 |
90993 | CREB3L1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.66e-14 | 9.42e-01 | -0.1808 |
90993 | CREB3L1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.15e-14 | 7.98e-01 | -0.0811 |
90993 | CREB3L1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.30e-19 | 9.32e-01 | -0.1088 |
90993 | CREB3L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.20e-36 | 1.03e+00 | -0.1954 |
90993 | CREB3L1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-15 | 1.85e+00 | -0.2602 |
90993 | CREB3L1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.16e-06 | 1.22e+00 | -0.2196 |
90993 | CREB3L1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.01e-08 | 7.33e-01 | -0.1207 |
90993 | CREB3L1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.19e-32 | 1.11e+00 | -0.1464 |
90993 | CREB3L1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-18 | 9.37e-01 | -0.1001 |
90993 | CREB3L1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.67e-16 | 6.72e-01 | -0.059 |
90993 | CREB3L1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.06e-03 | 6.53e-01 | -0.1706 |
90993 | CREB3L1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.66e-04 | 5.78e-01 | -0.2061 |
90993 | CREB3L1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.21e-07 | 8.13e-01 | -0.0842 |
90993 | CREB3L1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.29e-05 | 7.10e-01 | 0.0446 |
90993 | CREB3L1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.30e-05 | 5.37e-01 | -0.0177 |
90993 | CREB3L1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.72e-05 | 5.80e-01 | 0.0112 |
90993 | CREB3L1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.54e-06 | 4.61e-01 | 0.0588 |
90993 | CREB3L1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.44e-03 | 2.99e-01 | 0.281 |
90993 | CREB3L1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.97e-04 | -2.33e-01 | 0.3859 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0035967 | Colorectum | AD | cellular response to topologically incorrect protein | 42/3918 | 116/18723 | 1.04e-04 | 1.56e-03 | 42 |
GO:1905897 | Colorectum | AD | regulation of response to endoplasmic reticulum stress | 32/3918 | 82/18723 | 1.37e-04 | 1.95e-03 | 32 |
GO:0043620 | Colorectum | AD | regulation of DNA-templated transcription in response to stress | 23/3918 | 53/18723 | 1.86e-04 | 2.49e-03 | 23 |
GO:0036003 | Colorectum | AD | positive regulation of transcription from RNA polymerase II promoter in response to stress | 13/3918 | 24/18723 | 3.45e-04 | 4.03e-03 | 13 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0043618 | Colorectum | AD | regulation of transcription from RNA polymerase II promoter in response to stress | 20/3918 | 47/18723 | 6.54e-04 | 6.75e-03 | 20 |
GO:0006986 | Colorectum | AD | response to unfolded protein | 45/3918 | 137/18723 | 7.43e-04 | 7.48e-03 | 45 |
GO:1902236 | Colorectum | AD | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:0034620 | Colorectum | AD | cellular response to unfolded protein | 33/3918 | 96/18723 | 1.53e-03 | 1.29e-02 | 33 |
GO:1903573 | Colorectum | AD | negative regulation of response to endoplasmic reticulum stress | 18/3918 | 44/18723 | 2.06e-03 | 1.64e-02 | 18 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:20012421 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway | 59/2897 | 164/18723 | 8.42e-11 | 1.20e-08 | 59 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0502038 | Esophagus | ESCC | Prion disease | 193/4205 | 273/8465 | 6.42e-13 | 1.34e-11 | 6.89e-12 | 193 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0466817 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516338 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0521517 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0516114 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa0415213 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0492616 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa0493113 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0421115 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0492215 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CREB3L1 | SNV | Missense_Mutation | c.1376N>T | p.Ala459Val | p.A459V | Q96BA8 | protein_coding | tolerated_low_confidence(0.28) | benign(0) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
CREB3L1 | SNV | Missense_Mutation | c.960N>C | p.Lys320Asn | p.K320N | Q96BA8 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
CREB3L1 | insertion | Frame_Shift_Ins | novel | c.1297_1298insAAACCGAGGCCCAAAGAGAGTCTAT | p.Gly433GlufsTer46 | p.G433Efs*46 | Q96BA8 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
CREB3L1 | SNV | Missense_Mutation | c.403N>C | p.Glu135Gln | p.E135Q | Q96BA8 | protein_coding | tolerated(0.24) | possibly_damaging(0.709) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CREB3L1 | SNV | Missense_Mutation | c.802C>T | p.Arg268Trp | p.R268W | Q96BA8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CREB3L1 | SNV | Missense_Mutation | c.1225C>A | p.Leu409Met | p.L409M | Q96BA8 | protein_coding | tolerated(0.36) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CREB3L1 | SNV | Missense_Mutation | c.174N>A | p.Phe58Leu | p.F58L | Q96BA8 | protein_coding | tolerated(0.77) | probably_damaging(0.952) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CREB3L1 | SNV | Missense_Mutation | c.160C>A | p.Leu54Met | p.L54M | Q96BA8 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CREB3L1 | SNV | Missense_Mutation | rs749140671 | c.884N>A | p.Arg295Gln | p.R295Q | Q96BA8 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
CREB3L1 | SNV | Missense_Mutation | rs774678396 | c.1315C>T | p.Arg439Cys | p.R439C | Q96BA8 | protein_coding | tolerated(0.17) | benign(0.353) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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