Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CANX_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CANX_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CANX_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CANX_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CANX_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CANX_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CANX_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CANX_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CANX_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CANX_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CANX_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CANX_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00349758 | Breast | Precancer | protein folding in endoplasmic reticulum | 6/1080 | 11/18723 | 1.31e-05 | 3.30e-04 | 6 |
GO:00431619 | Breast | Precancer | proteasome-mediated ubiquitin-dependent protein catabolic process | 42/1080 | 412/18723 | 2.49e-04 | 3.72e-03 | 42 |
GO:00068986 | Breast | Precancer | receptor-mediated endocytosis | 27/1080 | 244/18723 | 9.01e-04 | 1.03e-02 | 27 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
GO:00093067 | Breast | Precancer | protein secretion | 33/1080 | 359/18723 | 5.65e-03 | 4.08e-02 | 33 |
GO:00355927 | Breast | Precancer | establishment of protein localization to extracellular region | 33/1080 | 360/18723 | 5.89e-03 | 4.21e-02 | 33 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:000645713 | Breast | IDC | protein folding | 47/1434 | 212/18723 | 2.31e-11 | 3.86e-09 | 47 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:003497614 | Breast | IDC | response to endoplasmic reticulum stress | 43/1434 | 256/18723 | 8.42e-07 | 3.82e-05 | 43 |
GO:000756813 | Breast | IDC | aging | 52/1434 | 339/18723 | 1.14e-06 | 5.10e-05 | 52 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:003497513 | Breast | IDC | protein folding in endoplasmic reticulum | 6/1434 | 11/18723 | 6.59e-05 | 1.35e-03 | 6 |
GO:000689813 | Breast | IDC | receptor-mediated endocytosis | 35/1434 | 244/18723 | 2.38e-04 | 3.75e-03 | 35 |
GO:007169212 | Breast | IDC | protein localization to extracellular region | 42/1434 | 368/18723 | 6.13e-03 | 4.38e-02 | 42 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414141 | Stomach | CSG | Protein processing in endoplasmic reticulum | 30/633 | 174/8465 | 1.21e-05 | 1.54e-04 | 1.11e-04 | 30 |
hsa041454 | Stomach | CSG | Phagosome | 23/633 | 152/8465 | 8.67e-04 | 6.37e-03 | 4.59e-03 | 23 |
hsa0461251 | Stomach | CSG | Antigen processing and presentation | 28/633 | 78/8465 | 5.62e-13 | 1.27e-11 | 9.13e-12 | 28 |
hsa051665 | Stomach | CSG | Human T-cell leukemia virus 1 infection | 39/633 | 222/8465 | 3.66e-07 | 6.43e-06 | 4.62e-06 | 39 |
hsa0414151 | Stomach | CSG | Protein processing in endoplasmic reticulum | 30/633 | 174/8465 | 1.21e-05 | 1.54e-04 | 1.11e-04 | 30 |
hsa041455 | Stomach | CSG | Phagosome | 23/633 | 152/8465 | 8.67e-04 | 6.37e-03 | 4.59e-03 | 23 |
hsa046126 | Stomach | CAG | Antigen processing and presentation | 21/368 | 78/8465 | 8.08e-12 | 3.34e-10 | 2.67e-10 | 21 |
hsa0414161 | Stomach | CAG | Protein processing in endoplasmic reticulum | 27/368 | 174/8465 | 6.47e-09 | 1.56e-07 | 1.25e-07 | 27 |
hsa051666 | Stomach | CAG | Human T-cell leukemia virus 1 infection | 24/368 | 222/8465 | 3.28e-05 | 3.95e-04 | 3.16e-04 | 24 |
hsa041456 | Stomach | CAG | Phagosome | 17/368 | 152/8465 | 3.10e-04 | 3.31e-03 | 2.65e-03 | 17 |
hsa046127 | Stomach | CAG | Antigen processing and presentation | 21/368 | 78/8465 | 8.08e-12 | 3.34e-10 | 2.67e-10 | 21 |
hsa0414171 | Stomach | CAG | Protein processing in endoplasmic reticulum | 27/368 | 174/8465 | 6.47e-09 | 1.56e-07 | 1.25e-07 | 27 |
hsa051667 | Stomach | CAG | Human T-cell leukemia virus 1 infection | 24/368 | 222/8465 | 3.28e-05 | 3.95e-04 | 3.16e-04 | 24 |
hsa041457 | Stomach | CAG | Phagosome | 17/368 | 152/8465 | 3.10e-04 | 3.31e-03 | 2.65e-03 | 17 |
hsa046128 | Stomach | WIM | Antigen processing and presentation | 19/284 | 78/8465 | 6.03e-12 | 5.17e-10 | 4.12e-10 | 19 |
hsa0414181 | Stomach | WIM | Protein processing in endoplasmic reticulum | 23/284 | 174/8465 | 1.53e-08 | 4.29e-07 | 3.42e-07 | 23 |
hsa051668 | Stomach | WIM | Human T-cell leukemia virus 1 infection | 20/284 | 222/8465 | 5.31e-05 | 5.95e-04 | 4.74e-04 | 20 |
hsa041458 | Stomach | WIM | Phagosome | 14/284 | 152/8465 | 5.66e-04 | 5.66e-03 | 4.51e-03 | 14 |
hsa046129 | Stomach | WIM | Antigen processing and presentation | 19/284 | 78/8465 | 6.03e-12 | 5.17e-10 | 4.12e-10 | 19 |
hsa0414191 | Stomach | WIM | Protein processing in endoplasmic reticulum | 23/284 | 174/8465 | 1.53e-08 | 4.29e-07 | 3.42e-07 | 23 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
CANX | MVA | Stomach | CAG | INHBB,HSP90B1,ST3GAL4, etc. | 9.29e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CAG/regulons_activity_in_dotplot.png) |
CANX | LYMEND | Stomach | CSG | INHBB,HSP90B1,ST3GAL4, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CSG/regulons_activity_in_dotplot.png) |
CANX | MYOFIB | Stomach | WIM | INHBB,HSP90B1,ST3GAL4, etc. | 1.23e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_WIM/regulons_activity_in_dotplot.png) |
CANX | MSC | Stomach | WIM | INHBB,HSP90B1,ST3GAL4, etc. | 8.59e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_WIM/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CANX | SNV | Missense_Mutation | novel | c.1057N>A | p.Pro353Thr | p.P353T | P27824 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
CANX | SNV | Missense_Mutation | | c.1196N>T | p.Pro399Leu | p.P399L | P27824 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CANX | SNV | Missense_Mutation | | c.274N>C | p.Asp92His | p.D92H | P27824 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CANX | insertion | In_Frame_Ins | novel | c.1602_1603insCTTGGG | p.Glu534_Lys535insLeuGly | p.E534_K535insLG | P27824 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CANX | insertion | In_Frame_Ins | novel | c.1603_1604insTCC | p.Lys535delinsIleGln | p.K535delinsIQ | P27824 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CANX | deletion | Frame_Shift_Del | rs760711956 | c.1305delT | p.Phe435LeufsTer12 | p.F435Lfs*12 | P27824 | protein_coding | | | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
CANX | deletion | Frame_Shift_Del | novel | c.135delN | p.Lys46AsnfsTer61 | p.K46Nfs*61 | P27824 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
CANX | SNV | Missense_Mutation | novel | c.1060N>G | p.Gln354Glu | p.Q354E | P27824 | protein_coding | tolerated(0.28) | benign(0.078) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
CANX | SNV | Missense_Mutation | rs756081134 | c.913N>A | p.Asp305Asn | p.D305N | P27824 | protein_coding | tolerated(0.07) | probably_damaging(0.914) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CANX | SNV | Missense_Mutation | novel | c.1244N>A | p.Arg415Lys | p.R415K | P27824 | protein_coding | tolerated(1) | benign(0) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |