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Gene: UBA52 |
Gene summary for UBA52 |
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Gene information | Species | Human | Gene symbol | UBA52 | Gene ID | 7311 |
Gene name | ubiquitin A-52 residue ribosomal protein fusion product 1 | |
Gene Alias | CEP52 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P62987 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7311 | UBA52 | GSM4909280 | Human | Breast | Precancer | 2.46e-02 | -3.67e-01 | 0.0305 |
7311 | UBA52 | GSM4909282 | Human | Breast | IDC | 5.43e-13 | 2.07e-01 | -0.0288 |
7311 | UBA52 | GSM4909285 | Human | Breast | IDC | 1.44e-51 | 3.20e-01 | 0.21 |
7311 | UBA52 | GSM4909286 | Human | Breast | IDC | 6.99e-34 | 2.51e-01 | 0.1081 |
7311 | UBA52 | GSM4909287 | Human | Breast | IDC | 3.97e-46 | 3.20e-01 | 0.2057 |
7311 | UBA52 | GSM4909288 | Human | Breast | IDC | 2.34e-08 | 2.07e-01 | 0.0988 |
7311 | UBA52 | GSM4909290 | Human | Breast | IDC | 5.42e-07 | 1.77e-01 | 0.2096 |
7311 | UBA52 | GSM4909291 | Human | Breast | IDC | 4.60e-04 | 1.57e-01 | 0.1753 |
7311 | UBA52 | GSM4909292 | Human | Breast | IDC | 9.25e-30 | 5.57e-01 | 0.1236 |
7311 | UBA52 | GSM4909293 | Human | Breast | IDC | 4.44e-38 | 3.76e-01 | 0.1581 |
7311 | UBA52 | GSM4909294 | Human | Breast | IDC | 2.21e-37 | 2.56e-01 | 0.2022 |
7311 | UBA52 | GSM4909296 | Human | Breast | IDC | 1.06e-18 | 1.50e-01 | 0.1524 |
7311 | UBA52 | GSM4909297 | Human | Breast | IDC | 3.00e-19 | -1.50e-01 | 0.1517 |
7311 | UBA52 | GSM4909298 | Human | Breast | IDC | 1.24e-22 | 2.43e-01 | 0.1551 |
7311 | UBA52 | GSM4909301 | Human | Breast | IDC | 1.79e-09 | 1.66e-01 | 0.1577 |
7311 | UBA52 | GSM4909302 | Human | Breast | IDC | 1.23e-07 | 8.43e-02 | 0.1545 |
7311 | UBA52 | GSM4909304 | Human | Breast | IDC | 3.45e-20 | 2.55e-01 | 0.1636 |
7311 | UBA52 | GSM4909307 | Human | Breast | IDC | 3.28e-09 | 1.41e-01 | 0.1569 |
7311 | UBA52 | GSM4909308 | Human | Breast | IDC | 3.72e-03 | 1.42e-01 | 0.158 |
7311 | UBA52 | GSM4909309 | Human | Breast | IDC | 1.87e-04 | -1.08e-01 | 0.0483 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000963623 | Breast | DCIS | response to toxic substance | 42/1390 | 262/18723 | 1.76e-06 | 6.56e-05 | 42 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000963614 | Cervix | HSIL_HPV | response to toxic substance | 24/737 | 262/18723 | 1.14e-04 | 2.36e-03 | 24 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:000963624 | Cervix | N_HPV | response to toxic substance | 27/534 | 262/18723 | 9.00e-09 | 1.71e-06 | 27 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:00021814 | Colorectum | FAP | cytoplasmic translation | 76/2622 | 148/18723 | 3.31e-27 | 2.03e-23 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301010 | Colorectum | CRC | Ribosome | 60/1091 | 167/8465 | 1.43e-14 | 2.78e-12 | 1.88e-12 | 60 |
hsa0517110 | Colorectum | CRC | Coronavirus disease - COVID-19 | 74/1091 | 232/8465 | 1.66e-14 | 2.78e-12 | 1.88e-12 | 74 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0513110 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa0413710 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa0301011 | Colorectum | CRC | Ribosome | 60/1091 | 167/8465 | 1.43e-14 | 2.78e-12 | 1.88e-12 | 60 |
hsa0517111 | Colorectum | CRC | Coronavirus disease - COVID-19 | 74/1091 | 232/8465 | 1.66e-14 | 2.78e-12 | 1.88e-12 | 74 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0513111 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa0413711 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0501226 | Endometrium | AEH | Parkinson disease | 115/1197 | 266/8465 | 6.24e-32 | 1.01e-29 | 7.42e-30 | 115 |
hsa0517126 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa0502220 | Endometrium | AEH | Pathways of neurodegeneration - multiple diseases | 137/1197 | 476/8465 | 9.27e-18 | 2.32e-16 | 1.70e-16 | 137 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0412016 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0413720 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa0516725 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa05012111 | Endometrium | AEH | Parkinson disease | 115/1197 | 266/8465 | 6.24e-32 | 1.01e-29 | 7.42e-30 | 115 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBA52 | SNV | Missense_Mutation | c.268N>T | p.Asn90Tyr | p.N90Y | P62987 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
UBA52 | SNV | Missense_Mutation | c.310N>T | p.His104Tyr | p.H104Y | P62987 | protein_coding | deleterious(0.04) | benign(0.317) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
UBA52 | SNV | Missense_Mutation | novel | c.170N>T | p.Ser57Leu | p.S57L | P62987 | protein_coding | deleterious(0.04) | benign(0.3) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBA52 | SNV | Missense_Mutation | rs563262392 | c.316N>T | p.Arg106Cys | p.R106C | P62987 | protein_coding | tolerated(0.16) | benign(0) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBA52 | SNV | Missense_Mutation | c.212N>C | p.Leu71Ser | p.L71S | P62987 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBA52 | SNV | Missense_Mutation | c.281N>C | p.Met94Thr | p.M94T | P62987 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBA52 | SNV | Missense_Mutation | c.22N>A | p.Leu8Ile | p.L8I | P62987 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
UBA52 | SNV | Missense_Mutation | novel | c.77T>C | p.Val26Ala | p.V26A | P62987 | protein_coding | deleterious(0) | possibly_damaging(0.595) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
UBA52 | SNV | Missense_Mutation | novel | c.72N>T | p.Glu24Asp | p.E24D | P62987 | protein_coding | tolerated(0.62) | benign(0.148) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
UBA52 | SNV | Missense_Mutation | c.124N>G | p.Arg42Gly | p.R42G | P62987 | protein_coding | deleterious(0) | benign(0.071) | TCGA-BK-A0CB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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