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Gene: TRADD |
Gene summary for TRADD |
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Gene information | Species | Human | Gene symbol | TRADD | Gene ID | 8717 |
Gene name | TNFRSF1A associated via death domain | |
Gene Alias | Hs.89862 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q15628 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8717 | TRADD | LZE4T | Human | Esophagus | ESCC | 1.88e-12 | 2.83e-01 | 0.0811 |
8717 | TRADD | LZE20T | Human | Esophagus | ESCC | 1.66e-02 | 1.36e-01 | 0.0662 |
8717 | TRADD | LZE22D1 | Human | Esophagus | HGIN | 4.22e-08 | 3.96e-01 | 0.0595 |
8717 | TRADD | LZE22T | Human | Esophagus | ESCC | 5.25e-04 | 4.53e-01 | 0.068 |
8717 | TRADD | LZE24T | Human | Esophagus | ESCC | 4.64e-22 | 8.11e-01 | 0.0596 |
8717 | TRADD | LZE21T | Human | Esophagus | ESCC | 2.89e-03 | 4.67e-01 | 0.0655 |
8717 | TRADD | P1T-E | Human | Esophagus | ESCC | 1.74e-19 | 7.77e-01 | 0.0875 |
8717 | TRADD | P2T-E | Human | Esophagus | ESCC | 8.39e-10 | 2.17e-01 | 0.1177 |
8717 | TRADD | P4T-E | Human | Esophagus | ESCC | 3.74e-21 | 4.98e-01 | 0.1323 |
8717 | TRADD | P5T-E | Human | Esophagus | ESCC | 1.97e-17 | 3.15e-01 | 0.1327 |
8717 | TRADD | P8T-E | Human | Esophagus | ESCC | 1.97e-30 | 4.48e-01 | 0.0889 |
8717 | TRADD | P9T-E | Human | Esophagus | ESCC | 1.14e-14 | 4.01e-01 | 0.1131 |
8717 | TRADD | P10T-E | Human | Esophagus | ESCC | 4.41e-17 | 2.18e-01 | 0.116 |
8717 | TRADD | P11T-E | Human | Esophagus | ESCC | 7.63e-22 | 7.75e-01 | 0.1426 |
8717 | TRADD | P12T-E | Human | Esophagus | ESCC | 4.17e-17 | 1.96e-01 | 0.1122 |
8717 | TRADD | P15T-E | Human | Esophagus | ESCC | 1.31e-15 | 3.54e-01 | 0.1149 |
8717 | TRADD | P16T-E | Human | Esophagus | ESCC | 3.77e-18 | 6.48e-02 | 0.1153 |
8717 | TRADD | P17T-E | Human | Esophagus | ESCC | 2.44e-15 | 7.19e-01 | 0.1278 |
8717 | TRADD | P19T-E | Human | Esophagus | ESCC | 6.31e-07 | 9.19e-01 | 0.1662 |
8717 | TRADD | P20T-E | Human | Esophagus | ESCC | 1.93e-34 | 6.74e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:009719126 | Esophagus | HGIN | extrinsic apoptotic signaling pathway | 56/2587 | 219/18723 | 2.48e-06 | 8.80e-05 | 56 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:000862518 | Esophagus | HGIN | extrinsic apoptotic signaling pathway via death domain receptors | 23/2587 | 82/18723 | 5.47e-04 | 7.73e-03 | 23 |
GO:003320910 | Esophagus | HGIN | tumor necrosis factor-mediated signaling pathway | 26/2587 | 99/18723 | 7.45e-04 | 9.90e-03 | 26 |
GO:19012247 | Esophagus | HGIN | positive regulation of NIK/NF-kappaB signaling | 18/2587 | 69/18723 | 4.94e-03 | 4.18e-02 | 18 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:000862519 | Esophagus | ESCC | extrinsic apoptotic signaling pathway via death domain receptors | 59/8552 | 82/18723 | 1.23e-06 | 1.52e-05 | 59 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:003320914 | Esophagus | ESCC | tumor necrosis factor-mediated signaling pathway | 67/8552 | 99/18723 | 7.87e-06 | 7.72e-05 | 67 |
GO:003461220 | Esophagus | ESCC | response to tumor necrosis factor | 149/8552 | 253/18723 | 1.47e-05 | 1.33e-04 | 149 |
GO:007135620 | Esophagus | ESCC | cellular response to tumor necrosis factor | 132/8552 | 229/18723 | 1.69e-04 | 1.11e-03 | 132 |
GO:00510926 | Esophagus | ESCC | positive regulation of NF-kappaB transcription factor activity | 91/8552 | 152/18723 | 2.91e-04 | 1.75e-03 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516212 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa0406411 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0515211 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0493612 | Oral cavity | OSCC | Alcoholic liver disease | 78/3704 | 142/8465 | 4.53e-03 | 1.12e-02 | 5.68e-03 | 78 |
hsa046221 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
hsa05132210 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
hsa0516929 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
hsa0516424 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa0516024 | Oral cavity | LP | Hepatitis C | 73/2418 | 157/8465 | 1.14e-06 | 1.36e-05 | 8.74e-06 | 73 |
hsa0520324 | Oral cavity | LP | Viral carcinogenesis | 90/2418 | 204/8465 | 1.20e-06 | 1.38e-05 | 8.89e-06 | 90 |
hsa0421026 | Oral cavity | LP | Apoptosis | 65/2418 | 136/8465 | 1.33e-06 | 1.48e-05 | 9.53e-06 | 65 |
hsa05130210 | Oral cavity | LP | Pathogenic Escherichia coli infection | 87/2418 | 197/8465 | 1.71e-06 | 1.78e-05 | 1.15e-05 | 87 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa05131210 | Oral cavity | LP | Shigellosis | 103/2418 | 247/8465 | 4.98e-06 | 4.14e-05 | 2.67e-05 | 103 |
hsa05167210 | Oral cavity | LP | Kaposi sarcoma-associated herpesvirus infection | 84/2418 | 194/8465 | 6.66e-06 | 5.16e-05 | 3.33e-05 | 84 |
hsa0465725 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0516221 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRADD | SNV | Missense_Mutation | c.98N>T | p.Ala33Val | p.A33V | Q15628 | protein_coding | tolerated(0.2) | benign(0) | TCGA-BH-A0C1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
TRADD | SNV | Missense_Mutation | novel | c.530N>T | p.Ser177Leu | p.S177L | Q15628 | protein_coding | tolerated(0.37) | benign(0) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRADD | SNV | Missense_Mutation | c.667G>A | p.Ala223Thr | p.A223T | Q15628 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TRADD | SNV | Missense_Mutation | c.934G>A | p.Ala312Thr | p.A312T | Q15628 | protein_coding | deleterious_low_confidence(0.01) | benign(0.06) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRADD | SNV | Missense_Mutation | novel | c.900N>A | p.Asp300Glu | p.D300E | Q15628 | protein_coding | tolerated(0.7) | benign(0.018) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRADD | SNV | Missense_Mutation | novel | c.811C>T | p.Arg271Cys | p.R271C | Q15628 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TRADD | SNV | Missense_Mutation | novel | c.468N>T | p.Glu156Asp | p.E156D | Q15628 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TRADD | SNV | Missense_Mutation | c.877G>A | p.Glu293Lys | p.E293K | Q15628 | protein_coding | tolerated(0.54) | benign(0.097) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
TRADD | SNV | Missense_Mutation | novel | c.5C>T | p.Ala2Val | p.A2V | Q15628 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.946) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TRADD | SNV | Missense_Mutation | novel | c.479N>A | p.Arg160Gln | p.R160Q | Q15628 | protein_coding | tolerated(0.6) | benign(0.006) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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