Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NFATC3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NFATC3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NFATC3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NFATC3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/NFATC3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NFATC3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NFATC3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NFATC3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NFATC3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061614 | Colorectum | AD | pri-miRNA transcription by RNA polymerase II | 24/3918 | 55/18723 | 1.22e-04 | 1.78e-03 | 24 |
GO:1902893 | Colorectum | AD | regulation of pri-miRNA transcription by RNA polymerase II | 23/3918 | 54/18723 | 2.60e-04 | 3.25e-03 | 23 |
GO:00616142 | Colorectum | MSS | pri-miRNA transcription by RNA polymerase II | 19/3467 | 55/18723 | 3.47e-03 | 2.59e-02 | 19 |
GO:19028932 | Colorectum | MSS | regulation of pri-miRNA transcription by RNA polymerase II | 18/3467 | 54/18723 | 6.70e-03 | 4.38e-02 | 18 |
GO:00616143 | Colorectum | FAP | pri-miRNA transcription by RNA polymerase II | 21/2622 | 55/18723 | 7.50e-06 | 2.25e-04 | 21 |
GO:19028933 | Colorectum | FAP | regulation of pri-miRNA transcription by RNA polymerase II | 20/2622 | 54/18723 | 2.09e-05 | 5.05e-04 | 20 |
GO:0048016 | Colorectum | FAP | inositol phosphate-mediated signaling | 16/2622 | 55/18723 | 2.78e-03 | 2.15e-02 | 16 |
GO:1902894 | Colorectum | FAP | negative regulation of pri-miRNA transcription by RNA polymerase II | 7/2622 | 17/18723 | 5.62e-03 | 3.61e-02 | 7 |
GO:00616144 | Colorectum | CRC | pri-miRNA transcription by RNA polymerase II | 18/2078 | 55/18723 | 1.53e-05 | 4.70e-04 | 18 |
GO:19028934 | Colorectum | CRC | regulation of pri-miRNA transcription by RNA polymerase II | 17/2078 | 54/18723 | 4.62e-05 | 1.10e-03 | 17 |
GO:19028941 | Colorectum | CRC | negative regulation of pri-miRNA transcription by RNA polymerase II | 7/2078 | 17/18723 | 1.46e-03 | 1.57e-02 | 7 |
GO:0097720 | Colorectum | CRC | calcineurin-mediated signaling | 13/2078 | 48/18723 | 1.72e-03 | 1.77e-02 | 13 |
GO:0033173 | Colorectum | CRC | calcineurin-NFAT signaling cascade | 12/2078 | 43/18723 | 1.93e-03 | 1.96e-02 | 12 |
GO:00480161 | Colorectum | CRC | inositol phosphate-mediated signaling | 14/2078 | 55/18723 | 2.21e-03 | 2.15e-02 | 14 |
GO:00616146 | Liver | NAFLD | pri-miRNA transcription by RNA polymerase II | 13/1882 | 55/18723 | 2.64e-03 | 2.42e-02 | 13 |
GO:19028936 | Liver | NAFLD | regulation of pri-miRNA transcription by RNA polymerase II | 12/1882 | 54/18723 | 6.44e-03 | 4.69e-02 | 12 |
GO:006161412 | Liver | Cirrhotic | pri-miRNA transcription by RNA polymerase II | 22/4634 | 55/18723 | 8.94e-03 | 4.12e-02 | 22 |
GO:006161422 | Liver | HCC | pri-miRNA transcription by RNA polymerase II | 35/7958 | 55/18723 | 1.26e-03 | 6.92e-03 | 35 |
GO:190289312 | Liver | HCC | regulation of pri-miRNA transcription by RNA polymerase II | 34/7958 | 54/18723 | 1.92e-03 | 9.78e-03 | 34 |
GO:19028942 | Liver | HCC | negative regulation of pri-miRNA transcription by RNA polymerase II | 13/7958 | 17/18723 | 4.77e-03 | 2.02e-02 | 13 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517010 | Lung | IAC | Human immunodeficiency virus 1 infection | 40/1053 | 212/8465 | 4.26e-03 | 2.00e-02 | 1.33e-02 | 40 |
hsa043608 | Lung | IAC | Axon guidance | 34/1053 | 182/8465 | 9.31e-03 | 3.62e-02 | 2.41e-02 | 34 |
hsa0421813 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa0516717 | Lung | IAC | Kaposi sarcoma-associated herpesvirus infection | 46/1053 | 194/8465 | 8.58e-06 | 2.14e-04 | 1.42e-04 | 46 |
hsa0541717 | Lung | IAC | Lipid and atherosclerosis | 48/1053 | 215/8465 | 3.02e-05 | 6.14e-04 | 4.08e-04 | 48 |
hsa0516617 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0431011 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0516315 | Lung | IAC | Human cytomegalovirus infection | 47/1053 | 225/8465 | 2.01e-04 | 2.42e-03 | 1.61e-03 | 47 |
hsa0513515 | Lung | IAC | Yersinia infection | 32/1053 | 137/8465 | 2.63e-04 | 2.76e-03 | 1.83e-03 | 32 |
hsa046251 | Lung | IAC | C-type lectin receptor signaling pathway | 26/1053 | 104/8465 | 3.15e-04 | 3.11e-03 | 2.06e-03 | 26 |
hsa046591 | Lung | IAC | Th17 cell differentiation | 26/1053 | 108/8465 | 5.91e-04 | 5.34e-03 | 3.54e-03 | 26 |
hsa049211 | Lung | IAC | Oxytocin signaling pathway | 33/1053 | 154/8465 | 1.09e-03 | 7.82e-03 | 5.19e-03 | 33 |
hsa046601 | Lung | IAC | T cell receptor signaling pathway | 23/1053 | 104/8465 | 3.88e-03 | 1.88e-02 | 1.25e-02 | 23 |
hsa0517013 | Lung | IAC | Human immunodeficiency virus 1 infection | 40/1053 | 212/8465 | 4.26e-03 | 2.00e-02 | 1.33e-02 | 40 |
hsa0436011 | Lung | IAC | Axon guidance | 34/1053 | 182/8465 | 9.31e-03 | 3.62e-02 | 2.41e-02 | 34 |
hsa0431021 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0541723 | Lung | AIS | Lipid and atherosclerosis | 46/961 | 215/8465 | 1.33e-05 | 3.32e-04 | 2.12e-04 | 46 |
hsa0421823 | Lung | AIS | Cellular senescence | 35/961 | 156/8465 | 5.09e-05 | 7.85e-04 | 5.03e-04 | 35 |
hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NFATC3 | MAST | Colorectum | AD | RPS6KA5,UBA6-AS1,PRELID2, etc. | 2.43e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_AD/regulons_activity_in_dotplot.png) |
NFATC3 | TH1 | Endometrium | ADJ | SMAGP,AC006064.2,S1PR1, etc. | 8.94e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TEFF | Endometrium | Healthy | SMAGP,AC006064.2,S1PR1, etc. | 2.68e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | BMEM | Endometrium | Healthy | SMAGP,AC006064.2,S1PR1, etc. | 1.43e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | BMEM | Liver | NAFLD | ZSCAN5A,AC116366.3,BICRAL, etc. | 9.23e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_NAFLD/regulons_activity_in_dotplot.png) |
NFATC3 | AT1 | Lung | Healthy | HAX1,CLDN18,ADIRF, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | NK | Lung | IAC | BRWD3,TMEM14A,SBNO1, etc. | 4.77e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD4TN | Lung | IAC | BRWD3,TMEM14A,SBNO1, etc. | 2.11e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TEFF | Lung | MIAC | PPM1D,SAMD3,CCND3, etc. | 9.86e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TCM | Lung | MIAC | PPM1D,SAMD3,CCND3, etc. | 3.66e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFATC3 | SNV | Missense_Mutation | novel | c.208N>T | p.His70Tyr | p.H70Y | Q12968 | protein_coding | deleterious(0.03) | benign(0.041) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
NFATC3 | SNV | Missense_Mutation | | c.1440G>T | p.Met480Ile | p.M480I | Q12968 | protein_coding | tolerated(0.35) | benign(0.101) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
NFATC3 | SNV | Missense_Mutation | novel | c.605N>T | p.Arg202Leu | p.R202L | Q12968 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A7-A26F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
NFATC3 | SNV | Missense_Mutation | rs772602157 | c.1652G>A | p.Arg551Gln | p.R551Q | Q12968 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFATC3 | SNV | Missense_Mutation | | c.301N>C | p.Gly101Arg | p.G101R | Q12968 | protein_coding | deleterious(0) | benign(0.244) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NFATC3 | SNV | Missense_Mutation | | c.2125G>C | p.Glu709Gln | p.E709Q | Q12968 | protein_coding | deleterious(0.01) | benign(0.358) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
NFATC3 | SNV | Missense_Mutation | | c.2314G>A | p.Glu772Lys | p.E772K | Q12968 | protein_coding | tolerated_low_confidence(0.98) | benign(0.098) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
NFATC3 | SNV | Missense_Mutation | | c.1970N>A | p.Gly657Glu | p.G657E | Q12968 | protein_coding | tolerated(0.9) | benign(0.027) | TCGA-E2-A1IH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
NFATC3 | SNV | Missense_Mutation | novel | c.3076A>T | p.Ile1026Phe | p.I1026F | Q12968 | protein_coding | deleterious_low_confidence(0) | benign(0.386) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NFATC3 | insertion | Frame_Shift_Ins | novel | c.2625_2626insT | p.Leu876SerfsTer25 | p.L876Sfs*25 | Q12968 | protein_coding | | | TCGA-A8-A08Z-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |