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Gene: MGST2 |
Gene summary for MGST2 |
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Gene information | Species | Human | Gene symbol | MGST2 | Gene ID | 4258 |
Gene name | microsomal glutathione S-transferase 2 | |
Gene Alias | GST2 | |
Cytomap | 4q31.1 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | Q99735 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4258 | MGST2 | CA_HPV_1 | Human | Cervix | CC | 2.50e-05 | -1.74e-01 | 0.0264 |
4258 | MGST2 | CA_HPV_3 | Human | Cervix | CC | 1.45e-05 | 1.02e-01 | 0.0414 |
4258 | MGST2 | CCII_1 | Human | Cervix | CC | 6.22e-05 | -3.90e-01 | 0.3249 |
4258 | MGST2 | Tumor | Human | Cervix | CC | 1.24e-13 | 5.15e-01 | 0.1241 |
4258 | MGST2 | sample3 | Human | Cervix | CC | 1.01e-21 | 4.97e-01 | 0.1387 |
4258 | MGST2 | L1 | Human | Cervix | CC | 2.02e-04 | -2.60e-01 | 0.0802 |
4258 | MGST2 | T3 | Human | Cervix | CC | 4.01e-16 | 5.09e-01 | 0.1389 |
4258 | MGST2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.09e-09 | 7.67e-01 | -0.1808 |
4258 | MGST2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.00e-06 | 7.56e-01 | -0.0811 |
4258 | MGST2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.00e-04 | 5.96e-01 | -0.1088 |
4258 | MGST2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.53e-25 | 1.03e+00 | -0.1954 |
4258 | MGST2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.71e-05 | 9.96e-01 | -0.2602 |
4258 | MGST2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.97e-05 | 7.51e-01 | -0.1526 |
4258 | MGST2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.33e-05 | 4.98e-01 | -0.1464 |
4258 | MGST2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.14e-08 | 9.09e-01 | -0.059 |
4258 | MGST2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.30e-03 | 7.70e-01 | -0.1706 |
4258 | MGST2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.48e-04 | 7.72e-01 | -0.2061 |
4258 | MGST2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.21e-03 | 6.23e-01 | -0.0179 |
4258 | MGST2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.10e-11 | 7.90e-01 | 0.096 |
4258 | MGST2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.31e-05 | 9.06e-01 | 0.0446 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:00022379 | Cervix | CC | response to molecule of bacterial origin | 78/2311 | 363/18723 | 5.55e-07 | 2.06e-05 | 78 |
GO:00324969 | Cervix | CC | response to lipopolysaccharide | 74/2311 | 343/18723 | 9.15e-07 | 3.25e-05 | 74 |
GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
GO:00313494 | Cervix | CC | positive regulation of defense response | 60/2311 | 278/18723 | 9.38e-06 | 2.11e-04 | 60 |
GO:00507273 | Cervix | CC | regulation of inflammatory response | 75/2311 | 386/18723 | 3.95e-05 | 6.18e-04 | 75 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
GO:00972379 | Cervix | CC | cellular response to toxic substance | 31/2311 | 124/18723 | 8.09e-05 | 1.10e-03 | 31 |
GO:00507294 | Cervix | CC | positive regulation of inflammatory response | 34/2311 | 142/18723 | 9.51e-05 | 1.25e-03 | 34 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00987549 | Cervix | CC | detoxification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:00464564 | Cervix | CC | icosanoid biosynthetic process | 15/2311 | 56/18723 | 2.60e-03 | 1.80e-02 | 15 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0097237 | Colorectum | AD | cellular response to toxic substance | 44/3918 | 124/18723 | 1.24e-04 | 1.80e-03 | 44 |
GO:1990748 | Colorectum | AD | cellular detoxification | 41/3918 | 116/18723 | 2.29e-04 | 2.97e-03 | 41 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520871 | Stomach | CAG | Chemical carcinogenesis - reactive oxygen species | 38/368 | 223/8465 | 2.20e-13 | 1.27e-11 | 1.02e-11 | 38 |
hsa0541871 | Stomach | CAG | Fluid shear stress and atherosclerosis | 22/368 | 139/8465 | 1.18e-07 | 2.28e-06 | 1.83e-06 | 22 |
hsa05208101 | Stomach | SIM | Chemical carcinogenesis - reactive oxygen species | 48/465 | 223/8465 | 8.30e-17 | 8.41e-15 | 6.75e-15 | 48 |
hsa05418101 | Stomach | SIM | Fluid shear stress and atherosclerosis | 25/465 | 139/8465 | 1.16e-07 | 2.07e-06 | 1.66e-06 | 25 |
hsa009802 | Stomach | SIM | Metabolism of xenobiotics by cytochrome P450 | 11/465 | 78/8465 | 3.37e-03 | 2.18e-02 | 1.75e-02 | 11 |
hsa004806 | Stomach | SIM | Glutathione metabolism | 9/465 | 57/8465 | 3.59e-03 | 2.28e-02 | 1.83e-02 | 9 |
hsa05208111 | Stomach | SIM | Chemical carcinogenesis - reactive oxygen species | 48/465 | 223/8465 | 8.30e-17 | 8.41e-15 | 6.75e-15 | 48 |
hsa05418111 | Stomach | SIM | Fluid shear stress and atherosclerosis | 25/465 | 139/8465 | 1.16e-07 | 2.07e-06 | 1.66e-06 | 25 |
hsa009803 | Stomach | SIM | Metabolism of xenobiotics by cytochrome P450 | 11/465 | 78/8465 | 3.37e-03 | 2.18e-02 | 1.75e-02 | 11 |
hsa004807 | Stomach | SIM | Glutathione metabolism | 9/465 | 57/8465 | 3.59e-03 | 2.28e-02 | 1.83e-02 | 9 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGST2 | SNV | Missense_Mutation | rs141597730 | c.268N>T | p.Arg90Cys | p.R90C | Q99735 | protein_coding | tolerated(0.1) | probably_damaging(1) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGST2 | insertion | Frame_Shift_Ins | novel | c.27_28insCTTCTCACTTTTTCCACAGGAGGTGAGAAAG | p.Ala10LeufsTer48 | p.A10Lfs*48 | Q99735 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MGST2 | SNV | Missense_Mutation | novel | c.115G>A | p.Ala39Thr | p.A39T | Q99735 | protein_coding | deleterious(0.05) | benign(0.109) | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGST2 | SNV | Missense_Mutation | rs141597730 | c.268N>T | p.Arg90Cys | p.R90C | Q99735 | protein_coding | tolerated(0.1) | probably_damaging(1) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
MGST2 | SNV | Missense_Mutation | novel | c.301N>A | p.Ala101Thr | p.A101T | Q99735 | protein_coding | tolerated(0.19) | benign(0.006) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MGST2 | SNV | Missense_Mutation | rs748417296 | c.205A>G | p.Met69Val | p.M69V | Q99735 | protein_coding | tolerated(0.63) | benign(0.006) | TCGA-DD-AADP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MGST2 | SNV | Missense_Mutation | c.118N>A | p.Val40Ile | p.V40I | Q99735 | protein_coding | tolerated(0.14) | benign(0.229) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MGST2 | SNV | Missense_Mutation | novel | c.379G>A | p.Ala127Thr | p.A127T | Q99735 | protein_coding | tolerated(0.27) | benign(0.399) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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