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Gene: RPS27 |
Gene summary for RPS27 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPS27 | Gene ID | 6232 |
Gene name | ribosomal protein S27 | |
Gene Alias | DBA17 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000028 | UniProtAcc | P42677 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6232 | RPS27 | CA_HPV_1 | Human | Cervix | CC | 3.12e-03 | 2.11e-02 | 0.0264 |
6232 | RPS27 | CA_HPV_2 | Human | Cervix | CC | 6.43e-09 | -1.95e-01 | 0.0391 |
6232 | RPS27 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 1.26e-06 | 1.43e-01 | 0.0116 |
6232 | RPS27 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.12e-08 | 1.15e-01 | 0.0208 |
6232 | RPS27 | N_HPV_1 | Human | Cervix | N_HPV | 3.39e-13 | 9.88e-02 | 0.0079 |
6232 | RPS27 | CCI_1 | Human | Cervix | CC | 4.43e-67 | -2.13e+00 | 0.528 |
6232 | RPS27 | CCI_2 | Human | Cervix | CC | 4.85e-62 | -2.14e+00 | 0.5249 |
6232 | RPS27 | CCI_3 | Human | Cervix | CC | 5.76e-77 | -2.19e+00 | 0.516 |
6232 | RPS27 | CCII_1 | Human | Cervix | CC | 2.31e-99 | -2.15e+00 | 0.3249 |
6232 | RPS27 | Tumor | Human | Cervix | CC | 2.81e-47 | -3.44e-01 | 0.1241 |
6232 | RPS27 | sample1 | Human | Cervix | CC | 1.74e-07 | -2.18e-01 | 0.0959 |
6232 | RPS27 | sample3 | Human | Cervix | CC | 3.87e-57 | -3.69e-01 | 0.1387 |
6232 | RPS27 | H2 | Human | Cervix | HSIL_HPV | 9.28e-51 | -4.45e-01 | 0.0632 |
6232 | RPS27 | T1 | Human | Cervix | CC | 3.25e-25 | -2.64e-01 | 0.0918 |
6232 | RPS27 | T3 | Human | Cervix | CC | 1.10e-63 | -3.63e-01 | 0.1389 |
6232 | RPS27 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.95e-139 | 2.86e+00 | 0.0155 |
6232 | RPS27 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.84e-85 | 3.04e+00 | -0.1808 |
6232 | RPS27 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.95e-40 | 2.84e+00 | 0.0216 |
6232 | RPS27 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.77e-78 | 2.95e+00 | -0.0811 |
6232 | RPS27 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.07e-37 | 1.47e+00 | -0.1088 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00422559 | Breast | Precancer | ribosome assembly | 21/1080 | 61/18723 | 1.06e-11 | 1.53e-09 | 21 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00422749 | Breast | Precancer | ribosomal small subunit biogenesis | 21/1080 | 73/18723 | 4.84e-10 | 4.39e-08 | 21 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00000289 | Breast | Precancer | ribosomal small subunit assembly | 10/1080 | 19/18723 | 2.24e-08 | 1.50e-06 | 10 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
GO:00432808 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/1080 | 129/18723 | 3.13e-07 | 1.50e-05 | 24 |
GO:00109509 | Breast | Precancer | positive regulation of endopeptidase activity | 29/1080 | 179/18723 | 4.23e-07 | 1.90e-05 | 29 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301081 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517181 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa0301091 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517191 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa03010101 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171101 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
hsa03010111 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171111 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS27 | SNV | Missense_Mutation | c.233N>T | p.Ser78Phe | p.S78F | P42677 | protein_coding | deleterious(0.01) | benign(0.25) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
RPS27 | SNV | Missense_Mutation | novel | c.16G>A | p.Asp6Asn | p.D6N | P42677 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-DD-AACF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RPS27 | SNV | Missense_Mutation | c.32C>T | p.Ser11Phe | p.S11F | P42677 | protein_coding | deleterious(0.03) | benign(0.044) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPS27 | SNV | Missense_Mutation | c.94N>G | p.Phe32Val | p.F32V | P42677 | protein_coding | deleterious(0.02) | possibly_damaging(0.687) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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