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Gene: RPS17 |
Gene summary for RPS17 |
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Gene information | Species | Human | Gene symbol | RPS17 | Gene ID | 6218 |
Gene name | ribosomal protein S17 | |
Gene Alias | DBA4 | |
Cytomap | 15q25.2 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P08708 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6218 | RPS17 | GSM4909281 | Human | Breast | IDC | 9.61e-46 | -4.17e-01 | 0.21 |
6218 | RPS17 | GSM4909282 | Human | Breast | IDC | 1.02e-37 | -3.38e-01 | -0.0288 |
6218 | RPS17 | GSM4909285 | Human | Breast | IDC | 1.65e-73 | -6.60e-01 | 0.21 |
6218 | RPS17 | GSM4909286 | Human | Breast | IDC | 1.22e-13 | 3.13e-01 | 0.1081 |
6218 | RPS17 | GSM4909287 | Human | Breast | IDC | 9.88e-57 | -9.97e-01 | 0.2057 |
6218 | RPS17 | GSM4909288 | Human | Breast | IDC | 5.04e-29 | -1.46e+00 | 0.0988 |
6218 | RPS17 | GSM4909291 | Human | Breast | IDC | 3.09e-02 | 1.99e-01 | 0.1753 |
6218 | RPS17 | GSM4909293 | Human | Breast | IDC | 4.46e-91 | -9.75e-01 | 0.1581 |
6218 | RPS17 | GSM4909294 | Human | Breast | IDC | 9.37e-85 | -1.42e+00 | 0.2022 |
6218 | RPS17 | GSM4909295 | Human | Breast | IDC | 3.22e-04 | -3.01e-01 | 0.0898 |
6218 | RPS17 | GSM4909298 | Human | Breast | IDC | 2.23e-03 | 2.97e-02 | 0.1551 |
6218 | RPS17 | GSM4909299 | Human | Breast | IDC | 1.63e-23 | -1.64e-01 | 0.035 |
6218 | RPS17 | GSM4909301 | Human | Breast | IDC | 4.39e-43 | -5.88e-01 | 0.1577 |
6218 | RPS17 | GSM4909302 | Human | Breast | IDC | 2.55e-11 | -3.25e-01 | 0.1545 |
6218 | RPS17 | GSM4909303 | Human | Breast | IDC | 1.31e-13 | -6.74e-01 | 0.0438 |
6218 | RPS17 | GSM4909304 | Human | Breast | IDC | 5.96e-72 | -8.71e-01 | 0.1636 |
6218 | RPS17 | GSM4909305 | Human | Breast | IDC | 3.86e-06 | 1.09e-02 | 0.0436 |
6218 | RPS17 | GSM4909306 | Human | Breast | IDC | 5.14e-33 | -2.72e-01 | 0.1564 |
6218 | RPS17 | GSM4909307 | Human | Breast | IDC | 1.84e-23 | -2.37e-01 | 0.1569 |
6218 | RPS17 | GSM4909308 | Human | Breast | IDC | 2.08e-33 | -2.79e-01 | 0.158 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00064138 | Breast | Precancer | translational initiation | 30/1080 | 118/18723 | 3.23e-12 | 5.58e-10 | 30 |
GO:00422749 | Breast | Precancer | ribosomal small subunit biogenesis | 21/1080 | 73/18723 | 4.84e-10 | 4.39e-08 | 21 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00022629 | Breast | Precancer | myeloid cell homeostasis | 27/1080 | 157/18723 | 3.10e-07 | 1.49e-05 | 27 |
GO:00341019 | Breast | Precancer | erythrocyte homeostasis | 23/1080 | 129/18723 | 1.20e-06 | 4.60e-05 | 23 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:00488729 | Breast | Precancer | homeostasis of number of cells | 32/1080 | 272/18723 | 1.03e-04 | 1.89e-03 | 32 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:000641313 | Breast | IDC | translational initiation | 31/1434 | 118/18723 | 7.29e-10 | 7.52e-08 | 31 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:004227414 | Breast | IDC | ribosomal small subunit biogenesis | 21/1434 | 73/18723 | 7.23e-08 | 4.42e-06 | 21 |
GO:003410114 | Breast | IDC | erythrocyte homeostasis | 27/1434 | 129/18723 | 1.34e-06 | 5.75e-05 | 27 |
GO:000226214 | Breast | IDC | myeloid cell homeostasis | 30/1434 | 157/18723 | 2.64e-06 | 1.01e-04 | 30 |
GO:000636414 | Breast | IDC | rRNA processing | 35/1434 | 225/18723 | 4.59e-05 | 1.03e-03 | 35 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301041 | Stomach | CSG | Ribosome | 64/633 | 167/8465 | 3.70e-30 | 1.17e-27 | 8.41e-28 | 64 |
hsa0517141 | Stomach | CSG | Coronavirus disease - COVID-19 | 69/633 | 232/8465 | 8.56e-25 | 1.35e-22 | 9.74e-23 | 69 |
hsa0301051 | Stomach | CSG | Ribosome | 64/633 | 167/8465 | 3.70e-30 | 1.17e-27 | 8.41e-28 | 64 |
hsa0517151 | Stomach | CSG | Coronavirus disease - COVID-19 | 69/633 | 232/8465 | 8.56e-25 | 1.35e-22 | 9.74e-23 | 69 |
hsa0301061 | Stomach | CAG | Ribosome | 61/368 | 167/8465 | 2.85e-41 | 8.23e-39 | 6.59e-39 | 61 |
hsa0517161 | Stomach | CAG | Coronavirus disease - COVID-19 | 63/368 | 232/8465 | 7.19e-34 | 1.04e-31 | 8.32e-32 | 63 |
hsa0301071 | Stomach | CAG | Ribosome | 61/368 | 167/8465 | 2.85e-41 | 8.23e-39 | 6.59e-39 | 61 |
hsa0517171 | Stomach | CAG | Coronavirus disease - COVID-19 | 63/368 | 232/8465 | 7.19e-34 | 1.04e-31 | 8.32e-32 | 63 |
hsa0301081 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517181 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa0301091 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517191 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa03010101 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171101 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
hsa03010111 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171111 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS17 | insertion | Frame_Shift_Ins | novel | c.58_59insCCAACCTTCAGGTCACTCAGCCTACAGTTGGGATGAATTTCAAAAC | p.Tyr20SerfsTer83 | p.Y20Sfs*83 | P08708 | protein_coding | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPS17 | insertion | Frame_Shift_Ins | novel | c.67_68insCA | p.Arg23ProfsTer29 | p.R23Pfs*29 | P08708 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
RPS17 | SNV | Missense_Mutation | novel | c.116N>T | p.Ala39Val | p.A39V | P08708 | protein_coding | deleterious(0.01) | benign(0.077) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RPS17 | SNV | Missense_Mutation | novel | c.394N>T | p.Arg132Trp | p.R132W | P08708 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR |
RPS17 | SNV | Missense_Mutation | novel | c.395N>A | p.Arg132Gln | p.R132Q | P08708 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS17 | SNV | Missense_Mutation | novel | c.315N>A | p.Met105Ile | p.M105I | P08708 | protein_coding | deleterious(0.03) | benign(0.053) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS17 | SNV | Missense_Mutation | novel | c.389C>T | p.Thr130Met | p.T130M | P08708 | protein_coding | tolerated(0.3) | benign(0.041) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS17 | SNV | Missense_Mutation | novel | c.174N>A | p.Met58Ile | p.M58I | P08708 | protein_coding | deleterious(0.04) | benign(0.077) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS17 | SNV | Missense_Mutation | novel | c.136N>T | p.Leu46Phe | p.L46F | P08708 | protein_coding | deleterious(0.02) | benign(0.082) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS17 | SNV | Missense_Mutation | novel | c.227A>C | p.Glu76Ala | p.E76A | P08708 | protein_coding | deleterious(0.01) | benign(0.281) | TCGA-33-4589-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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