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Gene: RPS12 |
Gene summary for RPS12 |
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Gene information | Species | Human | Gene symbol | RPS12 | Gene ID | 6206 |
Gene name | ribosomal protein S12 | |
Gene Alias | S12 | |
Cytomap | 6q23.2 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P25398 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6206 | RPS12 | GSM4909281 | Human | Breast | IDC | 5.18e-67 | -4.54e-01 | 0.21 |
6206 | RPS12 | GSM4909282 | Human | Breast | IDC | 2.90e-51 | -2.89e-01 | -0.0288 |
6206 | RPS12 | GSM4909286 | Human | Breast | IDC | 2.02e-64 | 2.71e-01 | 0.1081 |
6206 | RPS12 | GSM4909288 | Human | Breast | IDC | 7.10e-03 | 1.49e-01 | 0.0988 |
6206 | RPS12 | GSM4909290 | Human | Breast | IDC | 1.39e-02 | 8.90e-02 | 0.2096 |
6206 | RPS12 | GSM4909291 | Human | Breast | IDC | 1.86e-30 | -3.09e-01 | 0.1753 |
6206 | RPS12 | GSM4909292 | Human | Breast | IDC | 2.79e-14 | -4.24e-01 | 0.1236 |
6206 | RPS12 | GSM4909293 | Human | Breast | IDC | 7.72e-04 | 1.15e-01 | 0.1581 |
6206 | RPS12 | GSM4909296 | Human | Breast | IDC | 3.45e-03 | -9.26e-02 | 0.1524 |
6206 | RPS12 | GSM4909297 | Human | Breast | IDC | 4.68e-32 | -3.15e-01 | 0.1517 |
6206 | RPS12 | GSM4909301 | Human | Breast | IDC | 2.09e-17 | -1.28e-01 | 0.1577 |
6206 | RPS12 | GSM4909302 | Human | Breast | IDC | 8.90e-11 | -1.90e-01 | 0.1545 |
6206 | RPS12 | GSM4909304 | Human | Breast | IDC | 8.14e-20 | -1.28e-01 | 0.1636 |
6206 | RPS12 | GSM4909308 | Human | Breast | IDC | 1.87e-05 | -8.75e-02 | 0.158 |
6206 | RPS12 | GSM4909312 | Human | Breast | IDC | 3.30e-04 | -8.05e-02 | 0.1552 |
6206 | RPS12 | GSM4909317 | Human | Breast | IDC | 4.74e-21 | -2.66e-01 | 0.1355 |
6206 | RPS12 | GSM4909319 | Human | Breast | IDC | 7.47e-49 | -6.67e-01 | 0.1563 |
6206 | RPS12 | GSM4909320 | Human | Breast | IDC | 3.15e-24 | -5.40e-01 | 0.1575 |
6206 | RPS12 | GSM4909321 | Human | Breast | IDC | 6.47e-41 | -3.51e-01 | 0.1559 |
6206 | RPS12 | ctrl6 | Human | Breast | Precancer | 4.96e-02 | -1.29e-01 | -0.0061 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00301776 | Cervix | CC | positive regulation of Wnt signaling pathway | 31/2311 | 140/18723 | 8.01e-04 | 7.02e-03 | 31 |
GO:00902636 | Cervix | CC | positive regulation of canonical Wnt signaling pathway | 22/2311 | 106/18723 | 9.52e-03 | 4.72e-02 | 22 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301061 | Stomach | CAG | Ribosome | 61/368 | 167/8465 | 2.85e-41 | 8.23e-39 | 6.59e-39 | 61 |
hsa0517161 | Stomach | CAG | Coronavirus disease - COVID-19 | 63/368 | 232/8465 | 7.19e-34 | 1.04e-31 | 8.32e-32 | 63 |
hsa0301071 | Stomach | CAG | Ribosome | 61/368 | 167/8465 | 2.85e-41 | 8.23e-39 | 6.59e-39 | 61 |
hsa0517171 | Stomach | CAG | Coronavirus disease - COVID-19 | 63/368 | 232/8465 | 7.19e-34 | 1.04e-31 | 8.32e-32 | 63 |
hsa0301081 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517181 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa0301091 | Stomach | WIM | Ribosome | 49/284 | 167/8465 | 1.59e-33 | 4.44e-31 | 3.54e-31 | 49 |
hsa0517191 | Stomach | WIM | Coronavirus disease - COVID-19 | 53/284 | 232/8465 | 3.00e-30 | 4.20e-28 | 3.35e-28 | 53 |
hsa03010101 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171101 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
hsa03010111 | Stomach | SIM | Ribosome | 62/465 | 167/8465 | 3.51e-36 | 1.07e-33 | 8.57e-34 | 62 |
hsa05171111 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS12 | SNV | Missense_Mutation | novel | c.259G>A | p.Glu87Lys | p.E87K | P25398 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | novel | c.353N>A | p.Ser118Tyr | p.S118Y | P25398 | protein_coding | deleterious(0) | possibly_damaging(0.67) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RPS12 | SNV | Missense_Mutation | novel | c.251N>C | p.Lys84Thr | p.K84T | P25398 | protein_coding | tolerated(0.28) | possibly_damaging(0.517) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | rs757201840 | c.302N>A | p.Arg101His | p.R101H | P25398 | protein_coding | tolerated(0.07) | benign(0.034) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | novel | c.196N>A | p.Glu66Lys | p.E66K | P25398 | protein_coding | tolerated(0.22) | benign(0.037) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | c.127N>A | p.Asp43Asn | p.D43N | P25398 | protein_coding | deleterious(0.04) | benign(0.405) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPS12 | SNV | Missense_Mutation | c.218N>G | p.Gln73Arg | p.Q73R | P25398 | protein_coding | deleterious(0.05) | possibly_damaging(0.673) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
RPS12 | SNV | Missense_Mutation | novel | c.249N>T | p.Lys83Asn | p.K83N | P25398 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | novel | c.157G>T | p.Ala53Ser | p.A53S | P25398 | protein_coding | tolerated(0.12) | benign(0.443) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS12 | SNV | Missense_Mutation | novel | c.173N>T | p.Glu58Val | p.E58V | P25398 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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