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Gene: ATP5MC3 |
Gene summary for ATP5MC3 |
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Gene information | Species | Human | Gene symbol | ATP5MC3 | Gene ID | 518 |
Gene name | ATP synthase membrane subunit c locus 3 | |
Gene Alias | ATP5G3 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P48201 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
518 | ATP5MC3 | GSM4909281 | Human | Breast | IDC | 7.39e-43 | 8.60e-01 | 0.21 |
518 | ATP5MC3 | GSM4909282 | Human | Breast | IDC | 1.70e-81 | 1.03e+00 | -0.0288 |
518 | ATP5MC3 | GSM4909285 | Human | Breast | IDC | 3.25e-77 | 1.05e+00 | 0.21 |
518 | ATP5MC3 | GSM4909286 | Human | Breast | IDC | 3.47e-17 | 2.72e-01 | 0.1081 |
518 | ATP5MC3 | GSM4909287 | Human | Breast | IDC | 7.80e-43 | 8.39e-01 | 0.2057 |
518 | ATP5MC3 | GSM4909288 | Human | Breast | IDC | 6.13e-12 | 6.23e-01 | 0.0988 |
518 | ATP5MC3 | GSM4909289 | Human | Breast | IDC | 9.56e-06 | 5.95e-01 | 0.1064 |
518 | ATP5MC3 | GSM4909290 | Human | Breast | IDC | 6.19e-27 | 6.89e-01 | 0.2096 |
518 | ATP5MC3 | GSM4909291 | Human | Breast | IDC | 2.79e-19 | 6.28e-01 | 0.1753 |
518 | ATP5MC3 | GSM4909293 | Human | Breast | IDC | 4.32e-15 | 2.59e-01 | 0.1581 |
518 | ATP5MC3 | GSM4909294 | Human | Breast | IDC | 1.45e-14 | 5.14e-01 | 0.2022 |
518 | ATP5MC3 | GSM4909296 | Human | Breast | IDC | 1.39e-14 | 4.89e-01 | 0.1524 |
518 | ATP5MC3 | GSM4909297 | Human | Breast | IDC | 3.70e-04 | 3.06e-02 | 0.1517 |
518 | ATP5MC3 | GSM4909298 | Human | Breast | IDC | 5.05e-08 | 2.61e-01 | 0.1551 |
518 | ATP5MC3 | GSM4909301 | Human | Breast | IDC | 3.76e-04 | 3.56e-01 | 0.1577 |
518 | ATP5MC3 | GSM4909304 | Human | Breast | IDC | 1.57e-15 | 4.78e-01 | 0.1636 |
518 | ATP5MC3 | GSM4909305 | Human | Breast | IDC | 6.40e-12 | 3.71e-01 | 0.0436 |
518 | ATP5MC3 | GSM4909306 | Human | Breast | IDC | 3.82e-07 | 3.97e-01 | 0.1564 |
518 | ATP5MC3 | GSM4909307 | Human | Breast | IDC | 6.17e-13 | 5.41e-01 | 0.1569 |
518 | ATP5MC3 | GSM4909308 | Human | Breast | IDC | 1.29e-36 | 6.58e-01 | 0.158 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:19026008 | Breast | Precancer | proton transmembrane transport | 39/1080 | 157/18723 | 4.18e-15 | 1.18e-12 | 39 |
GO:00159857 | Breast | Precancer | energy coupled proton transport, down electrochemical gradient | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00159867 | Breast | Precancer | ATP synthesis coupled proton transport | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00067547 | Breast | Precancer | ATP biosynthetic process | 21/1080 | 57/18723 | 2.31e-12 | 4.26e-10 | 21 |
GO:00092067 | Breast | Precancer | purine ribonucleoside triphosphate biosynthetic process | 22/1080 | 68/18723 | 1.41e-11 | 1.88e-09 | 22 |
GO:00091457 | Breast | Precancer | purine nucleoside triphosphate biosynthetic process | 22/1080 | 69/18723 | 1.95e-11 | 2.43e-09 | 22 |
GO:00092017 | Breast | Precancer | ribonucleoside triphosphate biosynthetic process | 22/1080 | 74/18723 | 9.18e-11 | 1.00e-08 | 22 |
GO:00091448 | Breast | Precancer | purine nucleoside triphosphate metabolic process | 24/1080 | 88/18723 | 9.66e-11 | 1.03e-08 | 24 |
GO:00092057 | Breast | Precancer | purine ribonucleoside triphosphate metabolic process | 23/1080 | 82/18723 | 1.27e-10 | 1.34e-08 | 23 |
GO:00091427 | Breast | Precancer | nucleoside triphosphate biosynthetic process | 23/1080 | 85/18723 | 2.82e-10 | 2.69e-08 | 23 |
GO:00091997 | Breast | Precancer | ribonucleoside triphosphate metabolic process | 23/1080 | 89/18723 | 7.65e-10 | 6.66e-08 | 23 |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
GO:00196938 | Breast | Precancer | ribose phosphate metabolic process | 49/1080 | 396/18723 | 3.81e-07 | 1.78e-05 | 49 |
GO:00091528 | Breast | Precancer | purine ribonucleotide biosynthetic process | 28/1080 | 169/18723 | 4.17e-07 | 1.89e-05 | 28 |
GO:00463907 | Breast | Precancer | ribose phosphate biosynthetic process | 30/1080 | 190/18723 | 4.75e-07 | 2.11e-05 | 30 |
GO:00092607 | Breast | Precancer | ribonucleotide biosynthetic process | 29/1080 | 182/18723 | 6.05e-07 | 2.55e-05 | 29 |
GO:00091509 | Breast | Precancer | purine ribonucleotide metabolic process | 46/1080 | 368/18723 | 6.47e-07 | 2.71e-05 | 46 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00092598 | Breast | Precancer | ribonucleotide metabolic process | 47/1080 | 385/18723 | 9.69e-07 | 3.84e-05 | 47 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa001902 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa050202 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052082 | Colorectum | SER | Chemical carcinogenesis - reactive oxygen species | 103/1580 | 223/8465 | 1.60e-21 | 7.57e-20 | 5.50e-20 | 103 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa001903 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa050203 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052083 | Colorectum | SER | Chemical carcinogenesis - reactive oxygen species | 103/1580 | 223/8465 | 1.60e-21 | 7.57e-20 | 5.50e-20 | 103 |
hsa050163 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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