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Gene: TUBA4A |
Gene summary for TUBA4A |
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Gene information | Species | Human | Gene symbol | TUBA4A | Gene ID | 7277 |
Gene name | tubulin alpha 4a | |
Gene Alias | ALS22 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P68366 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7277 | TUBA4A | GSM4909282 | Human | Breast | IDC | 2.97e-03 | 2.76e-01 | -0.0288 |
7277 | TUBA4A | GSM4909286 | Human | Breast | IDC | 9.60e-05 | -2.81e-01 | 0.1081 |
7277 | TUBA4A | GSM4909294 | Human | Breast | IDC | 3.00e-11 | -3.04e-01 | 0.2022 |
7277 | TUBA4A | GSM4909297 | Human | Breast | IDC | 3.85e-05 | -2.48e-01 | 0.1517 |
7277 | TUBA4A | GSM4909298 | Human | Breast | IDC | 5.85e-04 | -2.64e-01 | 0.1551 |
7277 | TUBA4A | GSM4909308 | Human | Breast | IDC | 7.82e-07 | -3.22e-01 | 0.158 |
7277 | TUBA4A | GSM4909311 | Human | Breast | IDC | 2.12e-10 | -2.58e-01 | 0.1534 |
7277 | TUBA4A | GSM4909312 | Human | Breast | IDC | 6.97e-07 | -2.55e-01 | 0.1552 |
7277 | TUBA4A | GSM4909319 | Human | Breast | IDC | 1.37e-13 | -2.59e-01 | 0.1563 |
7277 | TUBA4A | GSM4909320 | Human | Breast | IDC | 4.34e-02 | -2.87e-01 | 0.1575 |
7277 | TUBA4A | GSM4909321 | Human | Breast | IDC | 6.24e-11 | -3.15e-01 | 0.1559 |
7277 | TUBA4A | brca1 | Human | Breast | Precancer | 1.18e-29 | 6.64e-01 | -0.0338 |
7277 | TUBA4A | brca2 | Human | Breast | Precancer | 1.06e-19 | 5.10e-01 | -0.024 |
7277 | TUBA4A | brca3 | Human | Breast | Precancer | 7.48e-06 | 3.04e-01 | -0.0263 |
7277 | TUBA4A | NCCBC14 | Human | Breast | DCIS | 8.84e-04 | -2.41e-01 | 0.2021 |
7277 | TUBA4A | NCCBC3 | Human | Breast | DCIS | 1.96e-02 | -2.44e-01 | 0.1198 |
7277 | TUBA4A | NCCBC5 | Human | Breast | DCIS | 1.77e-06 | -2.63e-01 | 0.2046 |
7277 | TUBA4A | P1 | Human | Breast | IDC | 7.69e-08 | -1.24e-01 | 0.1527 |
7277 | TUBA4A | DCIS2 | Human | Breast | DCIS | 2.95e-39 | 1.21e-01 | 0.0085 |
7277 | TUBA4A | CA_HPV_1 | Human | Cervix | CC | 6.81e-04 | -1.66e-01 | 0.0264 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501254 | Cervix | N_HPV | Parkinson disease | 45/349 | 266/8465 | 1.93e-16 | 1.75e-14 | 1.37e-14 | 45 |
hsa0502054 | Cervix | N_HPV | Prion disease | 39/349 | 273/8465 | 6.07e-12 | 4.13e-10 | 3.23e-10 | 39 |
hsa0501454 | Cervix | N_HPV | Amyotrophic lateral sclerosis | 41/349 | 364/8465 | 3.11e-09 | 1.06e-07 | 8.26e-08 | 41 |
hsa0501654 | Cervix | N_HPV | Huntington disease | 36/349 | 306/8465 | 9.73e-09 | 2.65e-07 | 2.07e-07 | 36 |
hsa0414552 | Cervix | N_HPV | Phagosome | 24/349 | 152/8465 | 1.17e-08 | 2.88e-07 | 2.25e-07 | 24 |
hsa0502254 | Cervix | N_HPV | Pathways of neurodegeneration - multiple diseases | 47/349 | 476/8465 | 1.48e-08 | 3.13e-07 | 2.45e-07 | 47 |
hsa0501054 | Cervix | N_HPV | Alzheimer disease | 41/349 | 384/8465 | 1.50e-08 | 3.13e-07 | 2.45e-07 | 41 |
hsa0513054 | Cervix | N_HPV | Pathogenic Escherichia coli infection | 25/349 | 197/8465 | 4.71e-07 | 8.00e-06 | 6.25e-06 | 25 |
hsa0513254 | Cervix | N_HPV | Salmonella infection | 28/349 | 249/8465 | 1.18e-06 | 1.64e-05 | 1.28e-05 | 28 |
hsa0453035 | Cervix | N_HPV | Tight junction | 16/349 | 169/8465 | 1.60e-03 | 1.01e-02 | 7.92e-03 | 16 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa05020210 | Esophagus | ESCC | Prion disease | 193/4205 | 273/8465 | 6.42e-13 | 1.34e-11 | 6.89e-12 | 193 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUBA4A | SNV | Missense_Mutation | c.473C>G | p.Ser158Cys | p.S158C | P68366 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TUBA4A | insertion | Frame_Shift_Ins | novel | c.301_302insC | p.Asn101ThrfsTer16 | p.N101Tfs*16 | P68366 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TUBA4A | insertion | Frame_Shift_Ins | novel | c.300_301insCTGGAGAAGGATTATGAGGAGGTGGGCATCG | p.Asn101LeufsTer26 | p.N101Lfs*26 | P68366 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TUBA4A | SNV | Missense_Mutation | novel | c.1153N>A | p.Ala385Thr | p.A385T | P68366 | protein_coding | tolerated_low_confidence(0.05) | benign(0.074) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TUBA4A | SNV | Missense_Mutation | novel | c.889G>C | p.Glu297Gln | p.E297Q | P68366 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.911) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TUBA4A | deletion | Frame_Shift_Del | novel | c.1097delN | p.Gly366ValfsTer13 | p.G366Vfs*13 | P68366 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
TUBA4A | SNV | Missense_Mutation | novel | c.977N>G | p.Lys326Arg | p.K326R | P68366 | protein_coding | tolerated_low_confidence(0.06) | benign(0.285) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TUBA4A | SNV | Missense_Mutation | c.236G>A | p.Arg79Gln | p.R79Q | P68366 | protein_coding | deleterious_low_confidence(0.02) | benign(0.079) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TUBA4A | SNV | Missense_Mutation | c.236G>A | p.Arg79Gln | p.R79Q | P68366 | protein_coding | deleterious_low_confidence(0.02) | benign(0.079) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TUBA4A | SNV | Missense_Mutation | c.629A>G | p.Tyr210Cys | p.Y210C | P68366 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.997) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7277 | TUBA4A | DRUGGABLE GENOME | MAYTANSINOL | MAYTANSINOL | 563462 | |
7277 | TUBA4A | DRUGGABLE GENOME | inhibitor | CHEMBL49642 | INDIBULIN | |
7277 | TUBA4A | DRUGGABLE GENOME | CHEMBL2304041 | SAGOPILONE | ||
7277 | TUBA4A | DRUGGABLE GENOME | 4-(PHENYLCARBAMOYL)BENZYLNITRATE | CHEMBL1795737 | 21664138 | |
7277 | TUBA4A | DRUGGABLE GENOME | NSC-753582 | CHEMBL2036124 | 22543234 | |
7277 | TUBA4A | DRUGGABLE GENOME | inhibitor | CHEMBL538943 | VINORELBINE TARTRATE | |
7277 | TUBA4A | DRUGGABLE GENOME | inhibitor | CHEMBL1742994 | BRENTUXIMAB VEDOTIN | |
7277 | TUBA4A | DRUGGABLE GENOME | inhibitor | CHEMBL3545252 | DOCETAXEL | |
7277 | TUBA4A | DRUGGABLE GENOME | CHEMBL2103826 | DAVUNETIDE | ||
7277 | TUBA4A | DRUGGABLE GENOME | inhibitor | CHEMBL428647 | PACLITAXEL |
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