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Gene: ITGA3 |
Gene summary for ITGA3 |
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Gene information | Species | Human | Gene symbol | ITGA3 | Gene ID | 3675 |
Gene name | integrin subunit alpha 3 | |
Gene Alias | CD49C | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A140VJM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3675 | ITGA3 | CA_HPV_1 | Human | Cervix | CC | 9.00e-07 | -1.97e-01 | 0.0264 |
3675 | ITGA3 | CCI_2 | Human | Cervix | CC | 1.79e-13 | 1.19e+00 | 0.5249 |
3675 | ITGA3 | Tumor | Human | Cervix | CC | 1.32e-05 | 2.88e-01 | 0.1241 |
3675 | ITGA3 | sample1 | Human | Cervix | CC | 1.87e-09 | 4.88e-01 | 0.0959 |
3675 | ITGA3 | sample3 | Human | Cervix | CC | 2.14e-10 | 4.40e-01 | 0.1387 |
3675 | ITGA3 | T1 | Human | Cervix | CC | 1.79e-17 | 5.22e-01 | 0.0918 |
3675 | ITGA3 | T3 | Human | Cervix | CC | 8.51e-14 | 4.04e-01 | 0.1389 |
3675 | ITGA3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.40e-12 | 7.73e-01 | -0.1808 |
3675 | ITGA3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.45e-06 | 5.49e-01 | -0.0811 |
3675 | ITGA3 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.03e-25 | 8.07e-01 | -0.1954 |
3675 | ITGA3 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.91e-10 | 1.27e+00 | -0.2602 |
3675 | ITGA3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.66e-02 | 4.94e-01 | -0.1526 |
3675 | ITGA3 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.50e-08 | 5.68e-01 | -0.1464 |
3675 | ITGA3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.08e-03 | 3.55e-01 | -0.1001 |
3675 | ITGA3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.27e-06 | 5.55e-01 | -0.059 |
3675 | ITGA3 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.09e-03 | 5.41e-01 | -0.0842 |
3675 | ITGA3 | A002-C-010 | Human | Colorectum | FAP | 3.40e-02 | -1.82e-01 | 0.242 |
3675 | ITGA3 | A015-C-203 | Human | Colorectum | FAP | 1.56e-09 | -1.89e-01 | -0.1294 |
3675 | ITGA3 | A002-C-201 | Human | Colorectum | FAP | 8.70e-04 | -1.99e-01 | 0.0324 |
3675 | ITGA3 | A001-C-108 | Human | Colorectum | FAP | 8.45e-06 | -1.78e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00072295 | Cervix | CC | integrin-mediated signaling pathway | 34/2311 | 107/18723 | 1.01e-07 | 5.25e-06 | 34 |
GO:00106349 | Cervix | CC | positive regulation of epithelial cell migration | 47/2311 | 176/18723 | 1.73e-07 | 8.01e-06 | 47 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0451019 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa052228 | Oral cavity | OSCC | Small cell lung cancer | 66/3704 | 92/8465 | 4.43e-08 | 3.38e-07 | 1.72e-07 | 66 |
hsa0481026 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa04510110 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa0522215 | Oral cavity | OSCC | Small cell lung cancer | 66/3704 | 92/8465 | 4.43e-08 | 3.38e-07 | 1.72e-07 | 66 |
hsa04810111 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0516523 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0522224 | Oral cavity | LP | Small cell lung cancer | 37/2418 | 92/8465 | 1.04e-02 | 3.72e-02 | 2.40e-02 | 37 |
hsa0516533 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0522234 | Oral cavity | LP | Small cell lung cancer | 37/2418 | 92/8465 | 1.04e-02 | 3.72e-02 | 2.40e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
COL1A1 | ITGA3_ITGB1 | COL1A1_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL1A2 | ITGA3_ITGB1 | COL1A2_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL4A1 | ITGA3_ITGB1 | COL4A1_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL4A2 | ITGA3_ITGB1 | COL4A2_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A1 | ITGA3_ITGB1 | COL6A1_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A2 | ITGA3_ITGB1 | COL6A2_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
COL6A3 | ITGA3_ITGB1 | COL6A3_ITGA3_ITGB1 | COLLAGEN | Cervix | ADJ |
LAMA2 | ITGA3_ITGB1 | LAMA2_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMA3 | ITGA3_ITGB1 | LAMA3_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMA4 | ITGA3_ITGB1 | LAMA4_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMA5 | ITGA3_ITGB1 | LAMA5_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMB1 | ITGA3_ITGB1 | LAMB1_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMB2 | ITGA3_ITGB1 | LAMB2_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMB3 | ITGA3_ITGB1 | LAMB3_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMC1 | ITGA3_ITGB1 | LAMC1_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
LAMC2 | ITGA3_ITGB1 | LAMC2_ITGA3_ITGB1 | LAMININ | Cervix | ADJ |
FN1 | ITGA3_ITGB1 | FN1_ITGA3_ITGB1 | FN1 | Cervix | ADJ |
THBS1 | ITGA3_ITGB1 | THBS1_ITGA3_ITGB1 | THBS | Cervix | ADJ |
THBS2 | ITGA3_ITGB1 | THBS2_ITGA3_ITGB1 | THBS | Cervix | ADJ |
JAM2 | ITGA3_ITGB1 | JAM2_ITGA3_ITGB1 | JAM | Cervix | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGA3 | SNV | Missense_Mutation | novel | c.2758N>A | p.Asp920Asn | p.D920N | P26006 | protein_coding | tolerated(1) | benign(0.007) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
ITGA3 | SNV | Missense_Mutation | novel | c.1321N>T | p.Asp441Tyr | p.D441Y | P26006 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-LL-A740-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ITGA3 | insertion | Frame_Shift_Ins | novel | c.1814_1815insG | p.Asn605LysfsTer4 | p.N605Kfs*4 | P26006 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ITGA3 | insertion | Frame_Shift_Ins | novel | c.1815_1816insCCTGTCTCTCCTCTTGGAGGGT | p.His606ProfsTer10 | p.H606Pfs*10 | P26006 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ITGA3 | insertion | Frame_Shift_Ins | novel | c.1760_1761insTATTA | p.Leu588IlefsTer54 | p.L588Ifs*54 | P26006 | protein_coding | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ITGA3 | insertion | Nonsense_Mutation | novel | c.1761_1762insTCCACCTTTCCAAGTAGGATATAGTTAAGACA | p.Leu588SerfsTer8 | p.L588Sfs*8 | P26006 | protein_coding | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ITGA3 | deletion | Frame_Shift_Del | novel | c.1335delN | p.Pro446GlnfsTer4 | p.P446Qfs*4 | P26006 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ITGA3 | SNV | Missense_Mutation | novel | c.3026N>G | p.Ile1009Ser | p.I1009S | P26006 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ITGA3 | SNV | Missense_Mutation | rs140248487 | c.2501N>T | p.Thr834Met | p.T834M | P26006 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ITGA3 | SNV | Missense_Mutation | rs778130201 | c.494G>A | p.Arg165Gln | p.R165Q | P26006 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3675 | ITGA3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | 252827506 |
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