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Gene: ARPC3 |
Gene summary for ARPC3 |
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Gene information | Species | Human | Gene symbol | ARPC3 | Gene ID | 10094 |
Gene name | actin related protein 2/3 complex subunit 3 | |
Gene Alias | ARC21 | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | O15145 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10094 | ARPC3 | GSM4909285 | Human | Breast | IDC | 3.69e-09 | 3.86e-01 | 0.21 |
10094 | ARPC3 | GSM4909286 | Human | Breast | IDC | 1.86e-09 | -1.19e-01 | 0.1081 |
10094 | ARPC3 | GSM4909293 | Human | Breast | IDC | 3.81e-03 | 8.09e-02 | 0.1581 |
10094 | ARPC3 | GSM4909294 | Human | Breast | IDC | 2.52e-21 | 3.16e-01 | 0.2022 |
10094 | ARPC3 | GSM4909296 | Human | Breast | IDC | 1.79e-13 | 1.99e-01 | 0.1524 |
10094 | ARPC3 | GSM4909297 | Human | Breast | IDC | 1.26e-23 | -6.55e-02 | 0.1517 |
10094 | ARPC3 | GSM4909304 | Human | Breast | IDC | 1.83e-03 | 2.47e-01 | 0.1636 |
10094 | ARPC3 | GSM4909311 | Human | Breast | IDC | 2.86e-46 | -3.05e-01 | 0.1534 |
10094 | ARPC3 | GSM4909312 | Human | Breast | IDC | 1.11e-11 | -1.63e-01 | 0.1552 |
10094 | ARPC3 | GSM4909313 | Human | Breast | IDC | 4.74e-03 | -2.35e-01 | 0.0391 |
10094 | ARPC3 | GSM4909315 | Human | Breast | IDC | 1.73e-30 | 5.21e-01 | 0.21 |
10094 | ARPC3 | GSM4909316 | Human | Breast | IDC | 2.39e-14 | 4.86e-01 | 0.21 |
10094 | ARPC3 | GSM4909318 | Human | Breast | IDC | 3.12e-11 | 5.67e-01 | 0.2031 |
10094 | ARPC3 | GSM4909319 | Human | Breast | IDC | 1.73e-52 | -3.47e-01 | 0.1563 |
10094 | ARPC3 | GSM4909320 | Human | Breast | IDC | 3.18e-08 | -3.40e-01 | 0.1575 |
10094 | ARPC3 | GSM4909321 | Human | Breast | IDC | 1.81e-14 | -7.21e-02 | 0.1559 |
10094 | ARPC3 | brca1 | Human | Breast | Precancer | 6.50e-24 | 5.48e-01 | -0.0338 |
10094 | ARPC3 | brca2 | Human | Breast | Precancer | 1.64e-12 | 4.03e-01 | -0.024 |
10094 | ARPC3 | brca3 | Human | Breast | Precancer | 1.12e-08 | 3.04e-01 | -0.0263 |
10094 | ARPC3 | brca10 | Human | Breast | Precancer | 1.65e-04 | 3.35e-01 | -0.0029 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00322739 | Breast | Precancer | positive regulation of protein polymerization | 18/1080 | 138/18723 | 9.85e-04 | 1.11e-02 | 18 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:19900908 | Breast | Precancer | cellular response to nerve growth factor stimulus | 9/1080 | 53/18723 | 3.05e-03 | 2.62e-02 | 9 |
GO:19900896 | Breast | Precancer | response to nerve growth factor | 9/1080 | 56/18723 | 4.47e-03 | 3.47e-02 | 9 |
GO:00343146 | Breast | Precancer | Arp2/3 complex-mediated actin nucleation | 7/1080 | 39/18723 | 6.32e-03 | 4.43e-02 | 7 |
GO:190290514 | Breast | IDC | positive regulation of supramolecular fiber organization | 37/1434 | 209/18723 | 1.33e-06 | 5.75e-05 | 37 |
GO:004325414 | Breast | IDC | regulation of protein-containing complex assembly | 61/1434 | 428/18723 | 1.77e-06 | 7.31e-05 | 61 |
GO:003133414 | Breast | IDC | positive regulation of protein-containing complex assembly | 40/1434 | 237/18723 | 1.77e-06 | 7.31e-05 | 40 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:190290314 | Breast | IDC | regulation of supramolecular fiber organization | 54/1434 | 383/18723 | 9.40e-06 | 2.66e-04 | 54 |
GO:003227314 | Breast | IDC | positive regulation of protein polymerization | 25/1434 | 138/18723 | 4.46e-05 | 1.01e-03 | 25 |
GO:005149513 | Breast | IDC | positive regulation of cytoskeleton organization | 35/1434 | 226/18723 | 5.04e-05 | 1.09e-03 | 35 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051325 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa046665 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051305 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051005 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
hsa051355 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa048105 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa051326 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa045306 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
hsa051316 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa051306 | Colorectum | MSI-H | Pathogenic Escherichia coli infection | 31/797 | 197/8465 | 2.90e-03 | 2.93e-02 | 2.46e-02 | 31 |
hsa051006 | Colorectum | MSI-H | Bacterial invasion of epithelial cells | 15/797 | 77/8465 | 4.86e-03 | 4.63e-02 | 3.88e-02 | 15 |
hsa051327 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa045307 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
hsa051317 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa051307 | Colorectum | MSI-H | Pathogenic Escherichia coli infection | 31/797 | 197/8465 | 2.90e-03 | 2.93e-02 | 2.46e-02 | 31 |
hsa051007 | Colorectum | MSI-H | Bacterial invasion of epithelial cells | 15/797 | 77/8465 | 4.86e-03 | 4.63e-02 | 3.88e-02 | 15 |
hsa045308 | Colorectum | FAP | Tight junction | 60/1404 | 169/8465 | 1.40e-09 | 9.33e-08 | 5.67e-08 | 60 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC3 | SNV | Missense_Mutation | novel | c.217N>A | p.Leu73Ile | p.L73I | O15145 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC3 | SNV | Missense_Mutation | novel | c.441N>C | p.Lys147Asn | p.K147N | O15145 | protein_coding | tolerated(0.05) | benign(0.112) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARPC3 | SNV | Missense_Mutation | novel | c.353N>T | p.Ala118Val | p.A118V | O15145 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARPC3 | SNV | Missense_Mutation | novel | c.163N>C | p.Phe55Leu | p.F55L | O15145 | protein_coding | deleterious(0.02) | probably_damaging(0.91) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARPC3 | SNV | Missense_Mutation | c.197N>T | p.Arg66Met | p.R66M | O15145 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARPC3 | SNV | Missense_Mutation | novel | c.372G>T | p.Gln124His | p.Q124H | O15145 | protein_coding | tolerated(0.14) | benign(0.02) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ARPC3 | SNV | Missense_Mutation | rs770287826 | c.362N>T | p.Ala121Val | p.A121V | O15145 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ARPC3 | SNV | Missense_Mutation | rs763570239 | c.7N>A | p.Ala3Thr | p.A3T | O15145 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARPC3 | SNV | Missense_Mutation | rs200224002 | c.290N>T | p.Thr97Met | p.T97M | O15145 | protein_coding | deleterious(0.03) | benign(0.381) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ARPC3 | SNV | Missense_Mutation | novel | c.202T>G | p.Leu68Val | p.L68V | O15145 | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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