Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/FOS_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/FOS_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/FOS_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/FOS_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/FOS_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/FOS_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/FOS_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/FOS_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/FOS_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/FOS_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/FOS_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/FOS_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/FOS_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00022378 | Breast | Precancer | response to molecule of bacterial origin | 43/1080 | 363/18723 | 6.05e-06 | 1.72e-04 | 43 |
GO:00324968 | Breast | Precancer | response to lipopolysaccharide | 41/1080 | 343/18723 | 7.94e-06 | 2.17e-04 | 41 |
GO:00466868 | Breast | Precancer | response to cadmium ion | 14/1080 | 68/18723 | 2.74e-05 | 6.21e-04 | 14 |
GO:00346149 | Breast | Precancer | cellular response to reactive oxygen species | 23/1080 | 155/18723 | 2.82e-05 | 6.31e-04 | 23 |
GO:00456379 | Breast | Precancer | regulation of myeloid cell differentiation | 28/1080 | 210/18723 | 3.05e-05 | 6.72e-04 | 28 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0493210 | Stomach | SIM | Non-alcoholic fatty liver disease | 38/465 | 155/8465 | 1.79e-15 | 1.09e-13 | 8.74e-14 | 38 |
hsa0541710 | Stomach | SIM | Lipid and atherosclerosis | 34/465 | 215/8465 | 1.80e-08 | 4.20e-07 | 3.37e-07 | 34 |
hsa05130101 | Stomach | SIM | Pathogenic Escherichia coli infection | 31/465 | 197/8465 | 8.76e-08 | 1.66e-06 | 1.34e-06 | 31 |
hsa05418101 | Stomach | SIM | Fluid shear stress and atherosclerosis | 25/465 | 139/8465 | 1.16e-07 | 2.07e-06 | 1.66e-06 | 25 |
hsa05132101 | Stomach | SIM | Salmonella infection | 32/465 | 249/8465 | 5.48e-06 | 7.57e-05 | 6.08e-05 | 32 |
hsa0516610 | Stomach | SIM | Human T-cell leukemia virus 1 infection | 28/465 | 222/8465 | 3.02e-05 | 3.82e-04 | 3.07e-04 | 28 |
hsa0465710 | Stomach | SIM | IL-17 signaling pathway | 16/465 | 94/8465 | 4.58e-05 | 5.57e-04 | 4.47e-04 | 16 |
hsa0491510 | Stomach | SIM | Estrogen signaling pathway | 20/465 | 138/8465 | 5.98e-05 | 6.73e-04 | 5.40e-04 | 20 |
hsa053238 | Stomach | SIM | Rheumatoid arthritis | 13/465 | 93/8465 | 1.61e-03 | 1.28e-02 | 1.03e-02 | 13 |
hsa0516710 | Stomach | SIM | Kaposi sarcoma-associated herpesvirus infection | 21/465 | 194/8465 | 2.18e-03 | 1.54e-02 | 1.24e-02 | 21 |
hsa051408 | Stomach | SIM | Leishmaniasis | 11/465 | 77/8465 | 3.04e-03 | 2.01e-02 | 1.61e-02 | 11 |
hsa05171111 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
hsa05208111 | Stomach | SIM | Chemical carcinogenesis - reactive oxygen species | 48/465 | 223/8465 | 8.30e-17 | 8.41e-15 | 6.75e-15 | 48 |
hsa0493211 | Stomach | SIM | Non-alcoholic fatty liver disease | 38/465 | 155/8465 | 1.79e-15 | 1.09e-13 | 8.74e-14 | 38 |
hsa0541711 | Stomach | SIM | Lipid and atherosclerosis | 34/465 | 215/8465 | 1.80e-08 | 4.20e-07 | 3.37e-07 | 34 |
hsa05130111 | Stomach | SIM | Pathogenic Escherichia coli infection | 31/465 | 197/8465 | 8.76e-08 | 1.66e-06 | 1.34e-06 | 31 |
hsa05418111 | Stomach | SIM | Fluid shear stress and atherosclerosis | 25/465 | 139/8465 | 1.16e-07 | 2.07e-06 | 1.66e-06 | 25 |
hsa05132111 | Stomach | SIM | Salmonella infection | 32/465 | 249/8465 | 5.48e-06 | 7.57e-05 | 6.08e-05 | 32 |
hsa0516611 | Stomach | SIM | Human T-cell leukemia virus 1 infection | 28/465 | 222/8465 | 3.02e-05 | 3.82e-04 | 3.07e-04 | 28 |
hsa0465711 | Stomach | SIM | IL-17 signaling pathway | 16/465 | 94/8465 | 4.58e-05 | 5.57e-04 | 4.47e-04 | 16 |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | SAPONIN | | 12451485 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | BACLOFEN | BACLOFEN | 11301212 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | ANTI-INFLAMMATORY DRUGS | | 11164833 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | INTERLEUKIN-1-BETA | | 8677009 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | PROTEIN KINASE A INHIBITOR | | 9093533 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | THROMBIN | THROMBIN | 2119237 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | MAPK INHIBITORS | | 14511403 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | BETA-INTERFERON | | 2491749 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | PACLITAXEL | PACLITAXEL | 9588740 |
2353 | FOS | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | MAGNESIUM SULFATE | | 11336444 |