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Gene: SHFM1 |
Gene summary for SHFM1 |
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Gene information | Species | Human | Gene symbol | SHFM1 | Gene ID | 7979 |
Gene name | SEM1 26S proteasome subunit | |
Gene Alias | C7orf76 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P60896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7979 | SHFM1 | GSM4909280 | Human | Breast | Precancer | 2.58e-03 | -4.59e-01 | 0.0305 |
7979 | SHFM1 | GSM4909281 | Human | Breast | IDC | 9.92e-21 | -4.59e-01 | 0.21 |
7979 | SHFM1 | GSM4909282 | Human | Breast | IDC | 3.31e-22 | -4.59e-01 | -0.0288 |
7979 | SHFM1 | GSM4909285 | Human | Breast | IDC | 4.25e-21 | -4.59e-01 | 0.21 |
7979 | SHFM1 | GSM4909286 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.1081 |
7979 | SHFM1 | GSM4909287 | Human | Breast | IDC | 3.47e-27 | -4.59e-01 | 0.2057 |
7979 | SHFM1 | GSM4909288 | Human | Breast | IDC | 5.54e-07 | -4.59e-01 | 0.0988 |
7979 | SHFM1 | GSM4909289 | Human | Breast | IDC | 4.60e-05 | -4.59e-01 | 0.1064 |
7979 | SHFM1 | GSM4909290 | Human | Breast | IDC | 9.70e-20 | -4.59e-01 | 0.2096 |
7979 | SHFM1 | GSM4909291 | Human | Breast | IDC | 3.67e-16 | -4.59e-01 | 0.1753 |
7979 | SHFM1 | GSM4909292 | Human | Breast | IDC | 2.45e-02 | -4.59e-01 | 0.1236 |
7979 | SHFM1 | GSM4909293 | Human | Breast | IDC | 3.31e-22 | -4.59e-01 | 0.1581 |
7979 | SHFM1 | GSM4909294 | Human | Breast | IDC | 4.25e-21 | -4.59e-01 | 0.2022 |
7979 | SHFM1 | GSM4909295 | Human | Breast | IDC | 7.13e-13 | -4.59e-01 | 0.0898 |
7979 | SHFM1 | GSM4909296 | Human | Breast | IDC | 1.82e-21 | -4.59e-01 | 0.1524 |
7979 | SHFM1 | GSM4909297 | Human | Breast | IDC | 5.96e-23 | -4.59e-01 | 0.1517 |
7979 | SHFM1 | GSM4909298 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.1551 |
7979 | SHFM1 | GSM4909299 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.035 |
7979 | SHFM1 | GSM4909300 | Human | Breast | IDC | 1.87e-11 | -4.59e-01 | 0.0334 |
7979 | SHFM1 | GSM4909301 | Human | Breast | IDC | 9.92e-21 | -4.59e-01 | 0.1577 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050201 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa030501 | Colorectum | AD | Proteasome | 29/2092 | 46/8465 | 3.87e-08 | 6.18e-07 | 3.94e-07 | 29 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050202 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa030502 | Colorectum | SER | Proteasome | 24/1580 | 46/8465 | 3.05e-07 | 5.96e-06 | 4.33e-06 | 24 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050203 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa050163 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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