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Gene: RPL35A |
Gene summary for RPL35A |
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Gene information | Species | Human | Gene symbol | RPL35A | Gene ID | 6165 |
Gene name | ribosomal protein L35a | |
Gene Alias | DBA5 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P18077 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6165 | RPL35A | GSM4909282 | Human | Breast | IDC | 2.90e-05 | -9.22e-02 | -0.0288 |
6165 | RPL35A | GSM4909285 | Human | Breast | IDC | 1.01e-61 | 3.01e-01 | 0.21 |
6165 | RPL35A | GSM4909286 | Human | Breast | IDC | 9.41e-45 | 2.26e-01 | 0.1081 |
6165 | RPL35A | GSM4909287 | Human | Breast | IDC | 4.10e-10 | -1.93e-01 | 0.2057 |
6165 | RPL35A | GSM4909294 | Human | Breast | IDC | 3.79e-07 | -1.58e-01 | 0.2022 |
6165 | RPL35A | GSM4909301 | Human | Breast | IDC | 1.94e-15 | -1.85e-01 | 0.1577 |
6165 | RPL35A | GSM4909302 | Human | Breast | IDC | 9.23e-11 | -2.17e-01 | 0.1545 |
6165 | RPL35A | GSM4909306 | Human | Breast | IDC | 2.65e-15 | -1.47e-01 | 0.1564 |
6165 | RPL35A | GSM4909307 | Human | Breast | IDC | 4.49e-20 | -1.77e-01 | 0.1569 |
6165 | RPL35A | GSM4909308 | Human | Breast | IDC | 1.78e-44 | -3.05e-01 | 0.158 |
6165 | RPL35A | GSM4909311 | Human | Breast | IDC | 1.05e-04 | 4.59e-02 | 0.1534 |
6165 | RPL35A | GSM4909313 | Human | Breast | IDC | 1.89e-03 | -1.46e-01 | 0.0391 |
6165 | RPL35A | GSM4909317 | Human | Breast | IDC | 1.63e-11 | -1.81e-01 | 0.1355 |
6165 | RPL35A | GSM4909319 | Human | Breast | IDC | 3.57e-39 | -6.21e-01 | 0.1563 |
6165 | RPL35A | GSM4909321 | Human | Breast | IDC | 4.64e-05 | -1.23e-01 | 0.1559 |
6165 | RPL35A | brca1 | Human | Breast | Precancer | 1.69e-10 | -1.02e-01 | -0.0338 |
6165 | RPL35A | brca2 | Human | Breast | Precancer | 1.88e-25 | -1.85e-01 | -0.024 |
6165 | RPL35A | brca3 | Human | Breast | Precancer | 2.69e-10 | -1.12e-01 | -0.0263 |
6165 | RPL35A | NCCBC14 | Human | Breast | DCIS | 2.96e-05 | -2.19e-01 | 0.2021 |
6165 | RPL35A | NCCBC3 | Human | Breast | DCIS | 1.94e-04 | -1.03e-01 | 0.1198 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00422739 | Breast | Precancer | ribosomal large subunit biogenesis | 22/1080 | 72/18723 | 5.03e-11 | 5.61e-09 | 22 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:004227314 | Breast | IDC | ribosomal large subunit biogenesis | 22/1434 | 72/18723 | 1.04e-08 | 7.67e-07 | 22 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:000636414 | Breast | IDC | rRNA processing | 35/1434 | 225/18723 | 4.59e-05 | 1.03e-03 | 35 |
GO:001607214 | Breast | IDC | rRNA metabolic process | 36/1434 | 236/18723 | 5.48e-05 | 1.17e-03 | 36 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:004227324 | Breast | DCIS | ribosomal large subunit biogenesis | 22/1390 | 72/18723 | 5.88e-09 | 4.82e-07 | 22 |
GO:004225423 | Breast | DCIS | ribosome biogenesis | 52/1390 | 299/18723 | 6.73e-09 | 5.44e-07 | 52 |
GO:000636422 | Breast | DCIS | rRNA processing | 35/1390 | 225/18723 | 2.41e-05 | 5.62e-04 | 35 |
GO:001607222 | Breast | DCIS | rRNA metabolic process | 36/1390 | 236/18723 | 2.86e-05 | 6.42e-04 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301043 | Lung | AAH | Ribosome | 63/348 | 167/8465 | 3.21e-45 | 8.95e-43 | 7.19e-43 | 63 |
hsa0517143 | Lung | AAH | Coronavirus disease - COVID-19 | 70/348 | 232/8465 | 9.07e-43 | 1.27e-40 | 1.02e-40 | 70 |
hsa0301053 | Lung | AAH | Ribosome | 63/348 | 167/8465 | 3.21e-45 | 8.95e-43 | 7.19e-43 | 63 |
hsa0517153 | Lung | AAH | Coronavirus disease - COVID-19 | 70/348 | 232/8465 | 9.07e-43 | 1.27e-40 | 1.02e-40 | 70 |
hsa0301063 | Lung | MIAC | Ribosome | 70/507 | 167/8465 | 1.80e-42 | 5.24e-40 | 3.79e-40 | 70 |
hsa0517163 | Lung | MIAC | Coronavirus disease - COVID-19 | 79/507 | 232/8465 | 4.83e-40 | 7.02e-38 | 5.08e-38 | 79 |
hsa0301073 | Lung | MIAC | Ribosome | 70/507 | 167/8465 | 1.80e-42 | 5.24e-40 | 3.79e-40 | 70 |
hsa0517173 | Lung | MIAC | Coronavirus disease - COVID-19 | 79/507 | 232/8465 | 4.83e-40 | 7.02e-38 | 5.08e-38 | 79 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa0517130 | Oral cavity | OSCC | Coronavirus disease - COVID-19 | 156/3704 | 232/8465 | 2.30e-13 | 5.14e-12 | 2.62e-12 | 156 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa05171114 | Oral cavity | OSCC | Coronavirus disease - COVID-19 | 156/3704 | 232/8465 | 2.30e-13 | 5.14e-12 | 2.62e-12 | 156 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa05171210 | Oral cavity | LP | Coronavirus disease - COVID-19 | 128/2418 | 232/8465 | 7.04e-18 | 2.34e-16 | 1.51e-16 | 128 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0517138 | Oral cavity | LP | Coronavirus disease - COVID-19 | 128/2418 | 232/8465 | 7.04e-18 | 2.34e-16 | 1.51e-16 | 128 |
hsa0517146 | Oral cavity | EOLP | Coronavirus disease - COVID-19 | 108/1218 | 232/8465 | 8.08e-33 | 2.61e-30 | 1.54e-30 | 108 |
hsa0301046 | Oral cavity | EOLP | Ribosome | 81/1218 | 167/8465 | 2.63e-26 | 4.25e-24 | 2.51e-24 | 81 |
hsa0517156 | Oral cavity | EOLP | Coronavirus disease - COVID-19 | 108/1218 | 232/8465 | 8.08e-33 | 2.61e-30 | 1.54e-30 | 108 |
hsa0301056 | Oral cavity | EOLP | Ribosome | 81/1218 | 167/8465 | 2.63e-26 | 4.25e-24 | 2.51e-24 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL35A | SNV | Missense_Mutation | c.76N>A | p.Ala26Thr | p.A26T | P18077 | protein_coding | tolerated(0.07) | benign(0.108) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPL35A | SNV | Missense_Mutation | novel | c.197N>C | p.Lys66Thr | p.K66T | P18077 | protein_coding | deleterious(0.01) | benign(0.123) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL35A | SNV | Missense_Mutation | c.137N>T | p.Arg46Ile | p.R46I | P18077 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
RPL35A | deletion | Frame_Shift_Del | novel | c.117_118delNN | p.Glu40IlefsTer12 | p.E40Ifs*12 | P18077 | protein_coding | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPL35A | SNV | Missense_Mutation | novel | c.41N>G | p.Tyr14Cys | p.Y14C | P18077 | protein_coding | deleterious(0.01) | benign(0.301) | TCGA-DD-AACY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RPL35A | SNV | Missense_Mutation | novel | c.226N>G | p.Arg76Gly | p.R76G | P18077 | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-33-AAS8-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL35A | SNV | Missense_Mutation | novel | c.134A>G | p.Lys45Arg | p.K45R | P18077 | protein_coding | deleterious(0.01) | possibly_damaging(0.887) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
RPL35A | SNV | Missense_Mutation | rs116840808 | c.97N>A | p.Val33Ile | p.V33I | P18077 | protein_coding | deleterious(0.02) | possibly_damaging(0.692) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RPL35A | SNV | Missense_Mutation | novel | c.91N>A | p.Glu31Lys | p.E31K | P18077 | protein_coding | deleterious(0.03) | benign(0.069) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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