![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HLA-DPA1 |
Gene summary for HLA-DPA1 |
![]() |
Gene information | Species | Human | Gene symbol | HLA-DPA1 | Gene ID | 3113 |
Gene name | major histocompatibility complex, class II, DP alpha 1 | |
Gene Alias | DP(W3) | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P20036 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3113 | HLA-DPA1 | GSM4909287 | Human | Breast | IDC | 6.52e-27 | 7.47e-01 | 0.2057 |
3113 | HLA-DPA1 | GSM4909290 | Human | Breast | IDC | 1.56e-05 | 2.71e-01 | 0.2096 |
3113 | HLA-DPA1 | GSM4909293 | Human | Breast | IDC | 9.07e-08 | 2.27e-01 | 0.1581 |
3113 | HLA-DPA1 | GSM4909305 | Human | Breast | IDC | 2.63e-02 | 2.19e-01 | 0.0436 |
3113 | HLA-DPA1 | GSM4909317 | Human | Breast | IDC | 8.08e-06 | 2.80e-01 | 0.1355 |
3113 | HLA-DPA1 | M1 | Human | Breast | IDC | 1.37e-17 | 5.64e-01 | 0.1577 |
3113 | HLA-DPA1 | M2 | Human | Breast | IDC | 1.83e-05 | 6.44e-01 | 0.21 |
3113 | HLA-DPA1 | NCCBC11 | Human | Breast | DCIS | 3.90e-09 | 8.54e-01 | 0.1232 |
3113 | HLA-DPA1 | NCCBC14 | Human | Breast | DCIS | 2.42e-07 | 4.77e-01 | 0.2021 |
3113 | HLA-DPA1 | NCCBC3 | Human | Breast | DCIS | 1.57e-73 | 1.47e+00 | 0.1198 |
3113 | HLA-DPA1 | NCCBC5 | Human | Breast | DCIS | 5.80e-28 | 9.67e-01 | 0.2046 |
3113 | HLA-DPA1 | P2 | Human | Breast | IDC | 4.77e-26 | 9.60e-01 | 0.21 |
3113 | HLA-DPA1 | DCIS2 | Human | Breast | DCIS | 1.03e-02 | 4.32e-02 | 0.0085 |
3113 | HLA-DPA1 | CA_HPV_1 | Human | Cervix | CC | 5.76e-10 | 6.60e-01 | 0.0264 |
3113 | HLA-DPA1 | CA_HPV_3 | Human | Cervix | CC | 4.76e-02 | -4.65e-01 | 0.0414 |
3113 | HLA-DPA1 | N_HPV_1 | Human | Cervix | N_HPV | 3.00e-05 | 2.45e-01 | 0.0079 |
3113 | HLA-DPA1 | CCI_1 | Human | Cervix | CC | 6.16e-10 | -1.04e+00 | 0.528 |
3113 | HLA-DPA1 | CCI_3 | Human | Cervix | CC | 9.65e-08 | -9.64e-01 | 0.516 |
3113 | HLA-DPA1 | CCII_1 | Human | Cervix | CC | 1.70e-18 | -1.04e+00 | 0.3249 |
3113 | HLA-DPA1 | Tumor | Human | Cervix | CC | 1.26e-17 | -5.58e-01 | 0.1241 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004800213 | Breast | IDC | antigen processing and presentation of peptide antigen | 18/1434 | 62/18723 | 5.28e-07 | 2.59e-05 | 18 |
GO:004578514 | Breast | IDC | positive regulation of cell adhesion | 62/1434 | 437/18723 | 1.70e-06 | 7.16e-05 | 62 |
GO:000250112 | Breast | IDC | peptide antigen assembly with MHC protein complex | 9/1434 | 18/18723 | 2.28e-06 | 9.05e-05 | 9 |
GO:000247813 | Breast | IDC | antigen processing and presentation of exogenous peptide antigen | 13/1434 | 38/18723 | 2.60e-06 | 1.01e-04 | 13 |
GO:000239612 | Breast | IDC | MHC protein complex assembly | 9/1434 | 19/18723 | 4.03e-06 | 1.43e-04 | 9 |
GO:00023997 | Breast | IDC | MHC class II protein complex assembly | 8/1434 | 16/18723 | 8.56e-06 | 2.47e-04 | 8 |
GO:00025037 | Breast | IDC | peptide antigen assembly with MHC class II protein complex | 8/1434 | 16/18723 | 8.56e-06 | 2.47e-04 | 8 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:005086311 | Breast | IDC | regulation of T cell activation | 47/1434 | 329/18723 | 2.49e-05 | 5.91e-04 | 47 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:00024957 | Breast | IDC | antigen processing and presentation of peptide antigen via MHC class II | 11/1434 | 34/18723 | 2.81e-05 | 6.58e-04 | 11 |
GO:001988413 | Breast | IDC | antigen processing and presentation of exogenous antigen | 13/1434 | 47/18723 | 3.53e-05 | 8.08e-04 | 13 |
GO:005087011 | Breast | IDC | positive regulation of T cell activation | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:001988613 | Breast | IDC | antigen processing and presentation of exogenous peptide antigen via MHC class II | 10/1434 | 30/18723 | 4.87e-05 | 1.07e-03 | 10 |
GO:00025047 | Breast | IDC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 11/1434 | 36/18723 | 5.13e-05 | 1.10e-03 | 11 |
GO:000715912 | Breast | IDC | leukocyte cell-cell adhesion | 49/1434 | 371/18723 | 1.27e-04 | 2.33e-03 | 49 |
GO:00198829 | Breast | IDC | antigen processing and presentation | 20/1434 | 106/18723 | 1.41e-04 | 2.49e-03 | 20 |
GO:190303911 | Breast | IDC | positive regulation of leukocyte cell-cell adhesion | 35/1434 | 239/18723 | 1.58e-04 | 2.73e-03 | 35 |
GO:190303711 | Breast | IDC | regulation of leukocyte cell-cell adhesion | 45/1434 | 336/18723 | 1.72e-04 | 2.92e-03 | 45 |
GO:002240712 | Breast | IDC | regulation of cell-cell adhesion | 55/1434 | 448/18723 | 3.43e-04 | 5.07e-03 | 55 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0514015 | Cervix | CC | Leishmaniasis | 21/1267 | 77/8465 | 3.65e-03 | 1.34e-02 | 7.91e-03 | 21 |
hsa046581 | Cervix | CC | Th1 and Th2 cell differentiation | 24/1267 | 92/8465 | 3.71e-03 | 1.34e-02 | 7.91e-03 | 24 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0532013 | Cervix | CC | Autoimmune thyroid disease | 15/1267 | 53/8465 | 9.08e-03 | 2.85e-02 | 1.69e-02 | 15 |
hsa0461224 | Cervix | HSIL_HPV | Antigen processing and presentation | 21/459 | 78/8465 | 5.10e-10 | 3.74e-08 | 3.02e-08 | 21 |
hsa051504 | Cervix | HSIL_HPV | Staphylococcus aureus infection | 21/459 | 96/8465 | 2.93e-08 | 1.43e-06 | 1.16e-06 | 21 |
hsa0414523 | Cervix | HSIL_HPV | Phagosome | 27/459 | 152/8465 | 3.58e-08 | 1.50e-06 | 1.21e-06 | 27 |
hsa0514022 | Cervix | HSIL_HPV | Leishmaniasis | 18/459 | 77/8465 | 9.82e-08 | 3.14e-06 | 2.54e-06 | 18 |
hsa0514522 | Cervix | HSIL_HPV | Toxoplasmosis | 22/459 | 112/8465 | 1.07e-07 | 3.14e-06 | 2.54e-06 | 22 |
hsa0531021 | Cervix | HSIL_HPV | Asthma | 11/459 | 31/8465 | 3.33e-07 | 8.88e-06 | 7.18e-06 | 11 |
hsa0541624 | Cervix | HSIL_HPV | Viral myocarditis | 14/459 | 60/8465 | 2.70e-06 | 4.95e-05 | 4.00e-05 | 14 |
hsa04640 | Cervix | HSIL_HPV | Hematopoietic cell lineage | 18/459 | 99/8465 | 4.97e-06 | 8.10e-05 | 6.54e-05 | 18 |
hsa0532322 | Cervix | HSIL_HPV | Rheumatoid arthritis | 16/459 | 93/8465 | 3.41e-05 | 5.26e-04 | 4.25e-04 | 16 |
hsa0516422 | Cervix | HSIL_HPV | Influenza A | 23/459 | 171/8465 | 4.65e-05 | 6.48e-04 | 5.24e-04 | 23 |
hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa0533022 | Cervix | HSIL_HPV | Allograft rejection | 9/459 | 38/8465 | 1.49e-04 | 1.74e-03 | 1.40e-03 | 9 |
hsa046725 | Cervix | HSIL_HPV | Intestinal immune network for IgA production | 10/459 | 49/8465 | 2.42e-04 | 2.53e-03 | 2.05e-03 | 10 |
hsa0451421 | Cervix | HSIL_HPV | Cell adhesion molecules | 20/459 | 157/8465 | 3.03e-04 | 3.06e-03 | 2.47e-03 | 20 |
hsa0533222 | Cervix | HSIL_HPV | Graft-versus-host disease | 9/459 | 42/8465 | 3.36e-04 | 3.28e-03 | 2.65e-03 | 9 |
hsa0516625 | Cervix | HSIL_HPV | Human T-cell leukemia virus 1 infection | 25/459 | 222/8465 | 3.95e-04 | 3.49e-03 | 2.82e-03 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | DCIS |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | IDC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | CC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | Precancer |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | AD |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | MSI-H |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | MSS |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | SER |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | AEH |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | EEC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | OSCC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | Precancer |
Page: 1 2 3 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HLA-DPA1 | SNV | Missense_Mutation | c.397C>T | p.Pro133Ser | p.P133S | P20036 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.325N>G | p.Asn109Asp | p.N109D | P20036 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs770307009 | c.746N>A | p.Arg249His | p.R249H | P20036 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-CM-4747-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs371532700 | c.137C>T | p.Thr46Met | p.T46M | P20036 | protein_coding | deleterious(0.04) | possibly_damaging(0.895) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | c.100N>A | p.Ala34Thr | p.A34T | P20036 | protein_coding | deleterious(0.03) | benign(0.106) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
HLA-DPA1 | SNV | Missense_Mutation | c.484G>T | p.Gly162Cys | p.G162C | P20036 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HLA-DPA1 | SNV | Missense_Mutation | rs751649425 | c.724N>A | p.Val242Ile | p.V242I | P20036 | protein_coding | tolerated(1) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.446N>G | p.Asn149Ser | p.N149S | P20036 | protein_coding | tolerated(0.18) | benign(0.033) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs761093053 | c.5N>A | p.Arg2His | p.R2H | P20036 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.718G>A | p.Gly240Ser | p.G240S | P20036 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3113 | HLA-DPA1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, CELL SURFACE | peginterferon alfa-2b | 26387494 |
Page: 1 |