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Gene: JUN |
Gene summary for JUN |
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Gene information | Species | Human | Gene symbol | JUN | Gene ID | 3725 |
Gene name | Jun proto-oncogene, AP-1 transcription factor subunit | |
Gene Alias | AP-1 | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P05412 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3725 | JUN | GSM4909277 | Human | Breast | Precancer | 7.18e-03 | 5.72e-01 | 0.0177 |
3725 | JUN | GSM4909280 | Human | Breast | Precancer | 2.42e-04 | 4.64e-01 | 0.0305 |
3725 | JUN | GSM4909281 | Human | Breast | IDC | 3.67e-06 | -3.81e-01 | 0.21 |
3725 | JUN | GSM4909286 | Human | Breast | IDC | 5.17e-21 | -5.96e-01 | 0.1081 |
3725 | JUN | GSM4909290 | Human | Breast | IDC | 3.50e-16 | -7.48e-01 | 0.2096 |
3725 | JUN | GSM4909294 | Human | Breast | IDC | 1.12e-18 | -5.17e-01 | 0.2022 |
3725 | JUN | GSM4909296 | Human | Breast | IDC | 9.17e-04 | -2.38e-01 | 0.1524 |
3725 | JUN | GSM4909297 | Human | Breast | IDC | 2.57e-19 | 2.40e-01 | 0.1517 |
3725 | JUN | GSM4909299 | Human | Breast | IDC | 7.60e-13 | 3.53e-01 | 0.035 |
3725 | JUN | GSM4909300 | Human | Breast | IDC | 1.92e-05 | 3.85e-01 | 0.0334 |
3725 | JUN | GSM4909301 | Human | Breast | IDC | 1.41e-02 | 1.86e-01 | 0.1577 |
3725 | JUN | GSM4909304 | Human | Breast | IDC | 9.85e-05 | -3.51e-01 | 0.1636 |
3725 | JUN | GSM4909305 | Human | Breast | IDC | 3.00e-12 | 3.98e-01 | 0.0436 |
3725 | JUN | GSM4909307 | Human | Breast | IDC | 2.30e-07 | -4.23e-01 | 0.1569 |
3725 | JUN | GSM4909311 | Human | Breast | IDC | 2.02e-23 | -1.01e-01 | 0.1534 |
3725 | JUN | GSM4909312 | Human | Breast | IDC | 3.80e-20 | 4.05e-01 | 0.1552 |
3725 | JUN | GSM4909315 | Human | Breast | IDC | 4.47e-14 | -4.67e-01 | 0.21 |
3725 | JUN | GSM4909316 | Human | Breast | IDC | 7.19e-11 | -8.51e-01 | 0.21 |
3725 | JUN | GSM4909317 | Human | Breast | IDC | 6.03e-12 | 3.80e-01 | 0.1355 |
3725 | JUN | GSM4909319 | Human | Breast | IDC | 1.13e-32 | 5.91e-02 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00086378 | Breast | Precancer | apoptotic mitochondrial changes | 23/1080 | 107/18723 | 3.44e-08 | 2.12e-06 | 23 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00425429 | Breast | Precancer | response to hydrogen peroxide | 26/1080 | 146/18723 | 2.52e-07 | 1.26e-05 | 26 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00511019 | Breast | Precancer | regulation of DNA binding | 22/1080 | 118/18723 | 9.28e-07 | 3.71e-05 | 22 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00018367 | Breast | Precancer | release of cytochrome c from mitochondria | 14/1080 | 59/18723 | 4.80e-06 | 1.47e-04 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0493312 | Lung | IAC | AGE-RAGE signaling pathway in diabetic complications | 24/1053 | 100/8465 | 9.91e-04 | 7.32e-03 | 4.86e-03 | 24 |
hsa049211 | Lung | IAC | Oxytocin signaling pathway | 33/1053 | 154/8465 | 1.09e-03 | 7.82e-03 | 5.19e-03 | 33 |
hsa0421012 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa0462111 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
hsa0521112 | Lung | IAC | Renal cell carcinoma | 18/1053 | 69/8465 | 1.51e-03 | 9.23e-03 | 6.13e-03 | 18 |
hsa0516917 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa0466812 | Lung | IAC | TNF signaling pathway | 25/1053 | 114/8465 | 3.01e-03 | 1.53e-02 | 1.02e-02 | 25 |
hsa0401212 | Lung | IAC | ErbB signaling pathway | 20/1053 | 85/8465 | 3.24e-03 | 1.62e-02 | 1.08e-02 | 20 |
hsa043801 | Lung | IAC | Osteoclast differentiation | 27/1053 | 128/8465 | 3.74e-03 | 1.84e-02 | 1.22e-02 | 27 |
hsa0517013 | Lung | IAC | Human immunodeficiency virus 1 infection | 40/1053 | 212/8465 | 4.26e-03 | 2.00e-02 | 1.33e-02 | 40 |
hsa0514011 | Lung | IAC | Leishmaniasis | 18/1053 | 77/8465 | 5.47e-03 | 2.44e-02 | 1.62e-02 | 18 |
hsa0491517 | Lung | IAC | Estrogen signaling pathway | 28/1053 | 138/8465 | 5.64e-03 | 2.45e-02 | 1.63e-02 | 28 |
hsa0491211 | Lung | IAC | GnRH signaling pathway | 20/1053 | 93/8465 | 9.36e-03 | 3.62e-02 | 2.41e-02 | 20 |
hsa0465715 | Lung | IAC | IL-17 signaling pathway | 20/1053 | 94/8465 | 1.05e-02 | 3.90e-02 | 2.59e-02 | 20 |
hsa051621 | Lung | IAC | Measles | 27/1053 | 139/8465 | 1.16e-02 | 4.20e-02 | 2.79e-02 | 27 |
hsa0514211 | Lung | IAC | Chagas disease | 21/1053 | 102/8465 | 1.30e-02 | 4.57e-02 | 3.04e-02 | 21 |
hsa0517123 | Lung | AIS | Coronavirus disease - COVID-19 | 98/961 | 232/8465 | 2.82e-34 | 9.14e-32 | 5.85e-32 | 98 |
hsa0451022 | Lung | AIS | Focal adhesion | 57/961 | 203/8465 | 3.17e-11 | 3.43e-09 | 2.19e-09 | 57 |
hsa0453023 | Lung | AIS | Tight junction | 46/961 | 169/8465 | 7.79e-09 | 4.33e-07 | 2.77e-07 | 46 |
hsa0513123 | Lung | AIS | Shigellosis | 53/961 | 247/8465 | 2.70e-06 | 9.71e-05 | 6.21e-05 | 53 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JUN | SNV | Missense_Mutation | c.334G>A | p.Glu112Lys | p.E112K | P05412 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
JUN | insertion | In_Frame_Ins | novel | c.862_863insGGGGCAACG | p.Lys288delinsArgGlyAsnGlu | p.K288delinsRGNE | P05412 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
JUN | SNV | Missense_Mutation | novel | c.659N>G | p.Pro220Arg | p.P220R | P05412 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
JUN | SNV | Missense_Mutation | c.635N>T | p.Pro212Leu | p.P212L | P05412 | protein_coding | tolerated(0.3) | benign(0.096) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
JUN | SNV | Missense_Mutation | c.350N>A | p.Ala117Asp | p.A117D | P05412 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
JUN | SNV | Missense_Mutation | novel | c.788G>A | p.Arg263His | p.R263H | P05412 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
JUN | insertion | Frame_Shift_Ins | novel | c.769dupA | p.Arg257LysfsTer53 | p.R257Kfs*53 | P05412 | protein_coding | TCGA-CM-6172-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | ||
JUN | insertion | Frame_Shift_Ins | novel | c.198_199insT | p.Gly67TrpfsTer40 | p.G67Wfs*40 | P05412 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
JUN | SNV | Missense_Mutation | c.870N>T | p.Gln290His | p.Q290H | P05412 | protein_coding | deleterious(0.02) | possibly_damaging(0.599) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
JUN | SNV | Missense_Mutation | novel | c.296N>A | p.Cys99Tyr | p.C99Y | P05412 | protein_coding | tolerated(1) | benign(0.012) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | DIPHENHYDRAMINE HYDROCHLORIDE | DIPHENHYDRAMINE HYDROCHLORIDE | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | COLCHICINE | COLCHICINE | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | CIPROFIBRATE | CIPROFIBRATE | 16680159 | |
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | VINBLASTINE SULFATE | VINBLASTINE SULFATE | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | PATULIN | PATULIN | 16680159 | |
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | ALPHA-DIFLUOROMETHYLORNITHINE | 9950818 | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | METHIMAZOLE | METHIMAZOLE | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | DFMO | 9950818 | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | 2-MERCAPTOPYRIMIDINE | 2-MERCAPTOPYRIMIDINE | ||
3725 | JUN | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | SODIUM SELENITE | SODIUM SELENITE |
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