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Gene: CDC42 |
Gene summary for CDC42 |
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Gene information | Species | Human | Gene symbol | CDC42 | Gene ID | 998 |
Gene name | cell division cycle 42 | |
Gene Alias | CDC42Hs | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RAE4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
998 | CDC42 | GSM4909285 | Human | Breast | IDC | 2.21e-18 | -5.83e-01 | 0.21 |
998 | CDC42 | GSM4909286 | Human | Breast | IDC | 3.63e-12 | -4.65e-01 | 0.1081 |
998 | CDC42 | GSM4909294 | Human | Breast | IDC | 1.64e-11 | 1.58e-01 | 0.2022 |
998 | CDC42 | GSM4909296 | Human | Breast | IDC | 1.08e-13 | -3.28e-01 | 0.1524 |
998 | CDC42 | GSM4909297 | Human | Breast | IDC | 1.54e-34 | 3.48e-01 | 0.1517 |
998 | CDC42 | GSM4909301 | Human | Breast | IDC | 3.06e-04 | -3.66e-01 | 0.1577 |
998 | CDC42 | GSM4909304 | Human | Breast | IDC | 6.71e-09 | 3.00e-01 | 0.1636 |
998 | CDC42 | GSM4909307 | Human | Breast | IDC | 3.64e-09 | -4.78e-01 | 0.1569 |
998 | CDC42 | GSM4909309 | Human | Breast | IDC | 7.03e-06 | -3.95e-01 | 0.0483 |
998 | CDC42 | GSM4909311 | Human | Breast | IDC | 2.49e-45 | -6.70e-01 | 0.1534 |
998 | CDC42 | GSM4909312 | Human | Breast | IDC | 1.49e-14 | -2.74e-01 | 0.1552 |
998 | CDC42 | GSM4909313 | Human | Breast | IDC | 4.68e-02 | -2.87e-02 | 0.0391 |
998 | CDC42 | GSM4909315 | Human | Breast | IDC | 3.05e-11 | 3.01e-01 | 0.21 |
998 | CDC42 | GSM4909316 | Human | Breast | IDC | 5.68e-05 | 2.94e-01 | 0.21 |
998 | CDC42 | GSM4909319 | Human | Breast | IDC | 9.52e-47 | -5.80e-01 | 0.1563 |
998 | CDC42 | GSM4909320 | Human | Breast | IDC | 2.23e-12 | -6.54e-01 | 0.1575 |
998 | CDC42 | GSM4909321 | Human | Breast | IDC | 1.91e-22 | -4.40e-01 | 0.1559 |
998 | CDC42 | ctrl6 | Human | Breast | Precancer | 5.69e-03 | 3.63e-01 | -0.0061 |
998 | CDC42 | NCCBC14 | Human | Breast | DCIS | 8.35e-30 | 4.21e-01 | 0.2021 |
998 | CDC42 | NCCBC5 | Human | Breast | DCIS | 3.21e-16 | 1.10e-01 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00217629 | Breast | Precancer | substantia nigra development | 15/1080 | 44/18723 | 1.12e-08 | 7.98e-07 | 15 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00309018 | Breast | Precancer | midbrain development | 20/1080 | 90/18723 | 1.50e-07 | 7.93e-06 | 20 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00488578 | Breast | Precancer | neural nucleus development | 16/1080 | 64/18723 | 4.76e-07 | 2.11e-05 | 16 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00190799 | Breast | Precancer | viral genome replication | 22/1080 | 131/18723 | 5.63e-06 | 1.66e-04 | 22 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513137 | Prostate | Tumor | Shigellosis | 94/1791 | 247/8465 | 5.56e-10 | 9.69e-09 | 6.01e-09 | 94 |
hsa0453037 | Prostate | Tumor | Tight junction | 69/1791 | 169/8465 | 3.92e-09 | 6.18e-08 | 3.83e-08 | 69 |
hsa0513037 | Prostate | Tumor | Pathogenic Escherichia coli infection | 77/1791 | 197/8465 | 5.20e-09 | 7.77e-08 | 4.82e-08 | 77 |
hsa0414435 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
hsa0481035 | Prostate | Tumor | Regulation of actin cytoskeleton | 84/1791 | 229/8465 | 3.40e-08 | 4.17e-07 | 2.58e-07 | 84 |
hsa0516532 | Prostate | Tumor | Human papillomavirus infection | 110/1791 | 331/8465 | 1.31e-07 | 1.51e-06 | 9.36e-07 | 110 |
hsa0510037 | Prostate | Tumor | Bacterial invasion of epithelial cells | 36/1791 | 77/8465 | 4.38e-07 | 4.53e-06 | 2.81e-06 | 36 |
hsa0520535 | Prostate | Tumor | Proteoglycans in cancer | 73/1791 | 205/8465 | 1.01e-06 | 9.82e-06 | 6.09e-06 | 73 |
hsa0520333 | Prostate | Tumor | Viral carcinogenesis | 70/1791 | 204/8465 | 7.53e-06 | 6.56e-05 | 4.07e-05 | 70 |
hsa0521232 | Prostate | Tumor | Pancreatic cancer | 33/1791 | 76/8465 | 9.72e-06 | 8.05e-05 | 4.99e-05 | 33 |
hsa0513534 | Prostate | Tumor | Yersinia infection | 48/1791 | 137/8465 | 1.11e-04 | 7.25e-04 | 4.49e-04 | 48 |
hsa0467037 | Prostate | Tumor | Leukocyte transendothelial migration | 41/1791 | 114/8465 | 1.80e-04 | 1.08e-03 | 6.68e-04 | 41 |
hsa0512033 | Prostate | Tumor | Epithelial cell signaling in Helicobacter pylori infection | 28/1791 | 70/8465 | 2.52e-04 | 1.43e-03 | 8.87e-04 | 28 |
hsa0401032 | Prostate | Tumor | MAPK signaling pathway | 87/1791 | 302/8465 | 8.46e-04 | 3.94e-03 | 2.45e-03 | 87 |
hsa0541737 | Prostate | Tumor | Lipid and atherosclerosis | 65/1791 | 215/8465 | 9.79e-04 | 4.44e-03 | 2.75e-03 | 65 |
hsa0521134 | Prostate | Tumor | Renal cell carcinoma | 26/1791 | 69/8465 | 1.20e-03 | 5.23e-03 | 3.25e-03 | 26 |
hsa0472233 | Prostate | Tumor | Neurotrophin signaling pathway | 39/1791 | 119/8465 | 2.01e-03 | 8.10e-03 | 5.02e-03 | 39 |
hsa0493332 | Prostate | Tumor | AGE-RAGE signaling pathway in diabetic complications | 33/1791 | 100/8465 | 3.79e-03 | 1.36e-02 | 8.46e-03 | 33 |
hsa0401533 | Prostate | Tumor | Rap1 signaling pathway | 60/1791 | 210/8465 | 6.16e-03 | 2.12e-02 | 1.32e-02 | 60 |
hsa0466632 | Prostate | Tumor | Fc gamma R-mediated phagocytosis | 31/1791 | 97/8465 | 8.27e-03 | 2.66e-02 | 1.65e-02 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC42 | SNV | Missense_Mutation | novel | c.560G>T | p.Arg187Met | p.R187M | P60953 | protein_coding | deleterious_low_confidence(0.01) | benign(0.102) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CDC42 | SNV | Missense_Mutation | c.248N>T | p.Ser83Leu | p.S83L | P60953 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
CDC42 | SNV | Missense_Mutation | c.498N>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CDC42 | SNV | Missense_Mutation | c.511N>A | p.Glu171Lys | p.E171K | P60953 | protein_coding | deleterious(0.03) | probably_damaging(0.976) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | c.498G>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | rs756680625 | c.557G>A | p.Arg186His | p.R186H | P60953 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | novel | c.80A>C | p.Lys27Thr | p.K27T | P60953 | protein_coding | tolerated(0.11) | benign(0.281) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | rs756680625 | c.557G>A | p.Arg186His | p.R186H | P60953 | protein_coding | tolerated(0.15) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC42 | SNV | Missense_Mutation | c.498N>T | p.Lys166Asn | p.K166N | P60953 | protein_coding | deleterious(0.01) | benign(0.288) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDC42 | SNV | Missense_Mutation | c.450G>T | p.Lys150Asn | p.K150N | P60953 | protein_coding | tolerated(0.15) | benign(0.068) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
998 | CDC42 | DRUGGABLE GENOME | SECRAMINE B | SECRAMINE B | 16408091 | |
998 | CDC42 | DRUGGABLE GENOME | SECRAMINE A | SECRAMINE A | 16408091 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-0073945 | CHEMBL563777 | 19527032 | |
998 | CDC42 | DRUGGABLE GENOME | GNRH | GONADORELIN ACETATE | 9626657 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-4194738 | CHEMBL554475 | 19527032 | |
998 | CDC42 | DRUGGABLE GENOME | ZU-3594419 | CHEMBL562095 | 19527032 |
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