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Gene: RPS10 |
Gene summary for RPS10 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPS10 | Gene ID | 6204 |
Gene name | ribosomal protein S10 | |
Gene Alias | DBA9 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P46783 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6204 | RPS10 | GSM4909281 | Human | Breast | IDC | 1.13e-42 | 4.01e-01 | 0.21 |
6204 | RPS10 | GSM4909282 | Human | Breast | IDC | 5.98e-24 | -4.79e-01 | -0.0288 |
6204 | RPS10 | GSM4909286 | Human | Breast | IDC | 1.07e-05 | 2.17e-01 | 0.1081 |
6204 | RPS10 | GSM4909287 | Human | Breast | IDC | 1.17e-55 | -1.04e+00 | 0.2057 |
6204 | RPS10 | GSM4909289 | Human | Breast | IDC | 2.23e-05 | -5.45e-01 | 0.1064 |
6204 | RPS10 | GSM4909290 | Human | Breast | IDC | 8.01e-25 | -5.95e-01 | 0.2096 |
6204 | RPS10 | GSM4909292 | Human | Breast | IDC | 1.40e-03 | -6.75e-01 | 0.1236 |
6204 | RPS10 | GSM4909293 | Human | Breast | IDC | 2.02e-02 | 1.96e-01 | 0.1581 |
6204 | RPS10 | GSM4909294 | Human | Breast | IDC | 2.77e-02 | -2.94e-01 | 0.2022 |
6204 | RPS10 | GSM4909296 | Human | Breast | IDC | 2.15e-16 | 2.48e-01 | 0.1524 |
6204 | RPS10 | GSM4909297 | Human | Breast | IDC | 1.72e-19 | -2.99e-01 | 0.1517 |
6204 | RPS10 | GSM4909300 | Human | Breast | IDC | 3.71e-03 | 1.51e-01 | 0.0334 |
6204 | RPS10 | GSM4909302 | Human | Breast | IDC | 8.56e-04 | -3.21e-01 | 0.1545 |
6204 | RPS10 | GSM4909304 | Human | Breast | IDC | 2.44e-33 | 3.79e-01 | 0.1636 |
6204 | RPS10 | GSM4909305 | Human | Breast | IDC | 3.87e-04 | -8.04e-02 | 0.0436 |
6204 | RPS10 | GSM4909307 | Human | Breast | IDC | 5.44e-04 | -2.30e-01 | 0.1569 |
6204 | RPS10 | GSM4909308 | Human | Breast | IDC | 2.20e-05 | -4.57e-02 | 0.158 |
6204 | RPS10 | GSM4909311 | Human | Breast | IDC | 1.28e-62 | 2.29e-01 | 0.1534 |
6204 | RPS10 | GSM4909312 | Human | Breast | IDC | 2.33e-08 | 1.77e-01 | 0.1552 |
6204 | RPS10 | GSM4909317 | Human | Breast | IDC | 1.54e-33 | -6.42e-01 | 0.1355 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0517142 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0517152 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa0301062 | Liver | Cyst | Ribosome | 70/339 | 167/8465 | 5.37e-55 | 1.55e-52 | 1.28e-52 | 70 |
hsa0517162 | Liver | Cyst | Coronavirus disease - COVID-19 | 75/339 | 232/8465 | 2.97e-49 | 4.27e-47 | 3.53e-47 | 75 |
hsa0301072 | Liver | Cyst | Ribosome | 70/339 | 167/8465 | 5.37e-55 | 1.55e-52 | 1.28e-52 | 70 |
hsa0517172 | Liver | Cyst | Coronavirus disease - COVID-19 | 75/339 | 232/8465 | 2.97e-49 | 4.27e-47 | 3.53e-47 | 75 |
hsa0517116 | Lung | IAC | Coronavirus disease - COVID-19 | 102/1053 | 232/8465 | 5.89e-34 | 1.91e-31 | 1.27e-31 | 102 |
hsa0301016 | Lung | IAC | Ribosome | 76/1053 | 167/8465 | 1.18e-26 | 1.91e-24 | 1.27e-24 | 76 |
hsa0517117 | Lung | IAC | Coronavirus disease - COVID-19 | 102/1053 | 232/8465 | 5.89e-34 | 1.91e-31 | 1.27e-31 | 102 |
hsa0301017 | Lung | IAC | Ribosome | 76/1053 | 167/8465 | 1.18e-26 | 1.91e-24 | 1.27e-24 | 76 |
hsa0517123 | Lung | AIS | Coronavirus disease - COVID-19 | 98/961 | 232/8465 | 2.82e-34 | 9.14e-32 | 5.85e-32 | 98 |
hsa0301023 | Lung | AIS | Ribosome | 76/961 | 167/8465 | 2.61e-29 | 4.22e-27 | 2.70e-27 | 76 |
hsa0517133 | Lung | AIS | Coronavirus disease - COVID-19 | 98/961 | 232/8465 | 2.82e-34 | 9.14e-32 | 5.85e-32 | 98 |
hsa0301033 | Lung | AIS | Ribosome | 76/961 | 167/8465 | 2.61e-29 | 4.22e-27 | 2.70e-27 | 76 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS10 | SNV | Missense_Mutation | c.348N>T | p.Arg116Ser | p.R116S | P46783 | protein_coding | tolerated(0.08) | possibly_damaging(0.642) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
RPS10 | deletion | Frame_Shift_Del | novel | c.355delN | p.Arg119GlufsTer? | p.R119Efs*? | P46783 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RPS10 | SNV | Missense_Mutation | c.414G>C | p.Lys138Asn | p.K138N | P46783 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
RPS10 | SNV | Missense_Mutation | novel | c.338G>A | p.Arg113Gln | p.R113Q | P46783 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS10 | SNV | Missense_Mutation | c.284G>A | p.Arg95His | p.R95H | P46783 | protein_coding | tolerated(0.08) | benign(0.04) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RPS10 | SNV | Missense_Mutation | novel | c.340C>T | p.Pro114Ser | p.P114S | P46783 | protein_coding | deleterious(0.04) | possibly_damaging(0.642) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPS10 | SNV | Missense_Mutation | rs776004367 | c.26N>C | p.Ile9Thr | p.I9T | P46783 | protein_coding | tolerated(0.43) | benign(0.088) | TCGA-AP-A05J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
RPS10 | SNV | Missense_Mutation | novel | c.430N>A | p.Ala144Thr | p.A144T | P46783 | protein_coding | tolerated(0.09) | benign(0.062) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS10 | SNV | Missense_Mutation | rs761359260 | c.293N>A | p.Arg98His | p.R98H | P46783 | protein_coding | tolerated(0.1) | benign(0.041) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RPS10 | SNV | Missense_Mutation | novel | c.487C>T | p.Pro163Ser | p.P163S | P46783 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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