Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RPL30_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RPL30_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RPL30_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/RPL30_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RPL30_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/RPL30_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RPL30_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RPL30_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RPL30_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RPL30_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RPL30_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RPL30_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301072 | Liver | Cyst | Ribosome | 70/339 | 167/8465 | 5.37e-55 | 1.55e-52 | 1.28e-52 | 70 |
hsa0517172 | Liver | Cyst | Coronavirus disease - COVID-19 | 75/339 | 232/8465 | 2.97e-49 | 4.27e-47 | 3.53e-47 | 75 |
hsa0517116 | Lung | IAC | Coronavirus disease - COVID-19 | 102/1053 | 232/8465 | 5.89e-34 | 1.91e-31 | 1.27e-31 | 102 |
hsa0301016 | Lung | IAC | Ribosome | 76/1053 | 167/8465 | 1.18e-26 | 1.91e-24 | 1.27e-24 | 76 |
hsa0517117 | Lung | IAC | Coronavirus disease - COVID-19 | 102/1053 | 232/8465 | 5.89e-34 | 1.91e-31 | 1.27e-31 | 102 |
hsa0301017 | Lung | IAC | Ribosome | 76/1053 | 167/8465 | 1.18e-26 | 1.91e-24 | 1.27e-24 | 76 |
hsa0517123 | Lung | AIS | Coronavirus disease - COVID-19 | 98/961 | 232/8465 | 2.82e-34 | 9.14e-32 | 5.85e-32 | 98 |
hsa0301023 | Lung | AIS | Ribosome | 76/961 | 167/8465 | 2.61e-29 | 4.22e-27 | 2.70e-27 | 76 |
hsa0517133 | Lung | AIS | Coronavirus disease - COVID-19 | 98/961 | 232/8465 | 2.82e-34 | 9.14e-32 | 5.85e-32 | 98 |
hsa0301033 | Lung | AIS | Ribosome | 76/961 | 167/8465 | 2.61e-29 | 4.22e-27 | 2.70e-27 | 76 |
hsa0301043 | Lung | AAH | Ribosome | 63/348 | 167/8465 | 3.21e-45 | 8.95e-43 | 7.19e-43 | 63 |
hsa0517143 | Lung | AAH | Coronavirus disease - COVID-19 | 70/348 | 232/8465 | 9.07e-43 | 1.27e-40 | 1.02e-40 | 70 |
hsa0301053 | Lung | AAH | Ribosome | 63/348 | 167/8465 | 3.21e-45 | 8.95e-43 | 7.19e-43 | 63 |
hsa0517153 | Lung | AAH | Coronavirus disease - COVID-19 | 70/348 | 232/8465 | 9.07e-43 | 1.27e-40 | 1.02e-40 | 70 |
hsa0301063 | Lung | MIAC | Ribosome | 70/507 | 167/8465 | 1.80e-42 | 5.24e-40 | 3.79e-40 | 70 |
hsa0517163 | Lung | MIAC | Coronavirus disease - COVID-19 | 79/507 | 232/8465 | 4.83e-40 | 7.02e-38 | 5.08e-38 | 79 |
hsa0301073 | Lung | MIAC | Ribosome | 70/507 | 167/8465 | 1.80e-42 | 5.24e-40 | 3.79e-40 | 70 |
hsa0517173 | Lung | MIAC | Coronavirus disease - COVID-19 | 79/507 | 232/8465 | 4.83e-40 | 7.02e-38 | 5.08e-38 | 79 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa0517130 | Oral cavity | OSCC | Coronavirus disease - COVID-19 | 156/3704 | 232/8465 | 2.30e-13 | 5.14e-12 | 2.62e-12 | 156 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL30 | insertion | In_Frame_Ins | novel | c.38_39insCTGCTTTTTTGGTTCTTTTAGCTTTGAGGT | p.Ser13_Ile14insCysPhePheGlySerPheSerPheGluVal | p.S13_I14insCFFGSFSFEV | P62888 | protein_coding | | | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL30 | insertion | Nonsense_Mutation | novel | c.243_244insTAAAGAGTTACACATCCTGGGCCGGGCGTGGTGGCT | p.Leu81_Gly82insTer | p.L81_G82ins* | P62888 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RPL30 | insertion | Nonsense_Mutation | novel | c.110_111insAGAATCACCTAGTTTAGCCCGCTAAATCAGTTCTGAGTCA | p.Met37IlefsTer9 | p.M37Ifs*9 | P62888 | protein_coding | | | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL30 | insertion | Frame_Shift_Ins | novel | c.110_111insTTTGTGTCCTGCTTTTTTGGTTCTTTTAGCTTTGA | p.Met37IlefsTer31 | p.M37Ifs*31 | P62888 | protein_coding | | | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
RPL30 | SNV | Missense_Mutation | novel | c.45N>A | p.Asn15Lys | p.N15K | P62888 | protein_coding | deleterious(0.03) | probably_damaging(0.929) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RPL30 | SNV | Missense_Mutation | novel | c.130A>G | p.Lys44Glu | p.K44E | P62888 | protein_coding | deleterious(0.02) | possibly_damaging(0.558) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPL30 | SNV | Missense_Mutation | novel | c.302N>G | p.Asp101Gly | p.D101G | P62888 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RPL30 | SNV | Missense_Mutation | novel | c.17N>C | p.Lys6Thr | p.K6T | P62888 | protein_coding | deleterious(0.01) | benign(0.367) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL30 | SNV | Missense_Mutation | | c.10G>C | p.Ala4Pro | p.A4P | P62888 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
RPL30 | deletion | Nonsense_Mutation | novel | c.267_268delNN | p.Tyr89Ter | p.Y89* | P62888 | protein_coding | | | TCGA-44-3396-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD |