Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/RIPK1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RIPK1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/RIPK1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RIPK1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123316 | Endometrium | AEH | regulation of apoptotic signaling pathway | 86/2100 | 356/18723 | 2.97e-12 | 4.95e-10 | 86 |
GO:000697916 | Endometrium | AEH | response to oxidative stress | 93/2100 | 446/18723 | 1.94e-09 | 1.64e-07 | 93 |
GO:000030216 | Endometrium | AEH | response to reactive oxygen species | 54/2100 | 222/18723 | 2.54e-08 | 1.49e-06 | 54 |
GO:20012358 | Endometrium | AEH | positive regulation of apoptotic signaling pathway | 36/2100 | 126/18723 | 7.56e-08 | 3.92e-06 | 36 |
GO:006219716 | Endometrium | AEH | cellular response to chemical stress | 71/2100 | 337/18723 | 1.03e-07 | 5.05e-06 | 71 |
GO:004254215 | Endometrium | AEH | response to hydrogen peroxide | 38/2100 | 146/18723 | 4.70e-07 | 1.92e-05 | 38 |
GO:009719116 | Endometrium | AEH | extrinsic apoptotic signaling pathway | 49/2100 | 219/18723 | 1.58e-06 | 4.94e-05 | 49 |
GO:200123416 | Endometrium | AEH | negative regulation of apoptotic signaling pathway | 49/2100 | 224/18723 | 3.12e-06 | 8.58e-05 | 49 |
GO:200123616 | Endometrium | AEH | regulation of extrinsic apoptotic signaling pathway | 37/2100 | 151/18723 | 3.17e-06 | 8.69e-05 | 37 |
GO:003459916 | Endometrium | AEH | cellular response to oxidative stress | 58/2100 | 288/18723 | 6.49e-06 | 1.58e-04 | 58 |
GO:00431229 | Endometrium | AEH | regulation of I-kappaB kinase/NF-kappaB signaling | 52/2100 | 249/18723 | 6.58e-06 | 1.59e-04 | 52 |
GO:00514039 | Endometrium | AEH | stress-activated MAPK cascade | 50/2100 | 239/18723 | 9.33e-06 | 2.18e-04 | 50 |
GO:00310989 | Endometrium | AEH | stress-activated protein kinase signaling cascade | 51/2100 | 247/18723 | 1.12e-05 | 2.52e-04 | 51 |
GO:00328728 | Endometrium | AEH | regulation of stress-activated MAPK cascade | 42/2100 | 192/18723 | 1.53e-05 | 3.23e-04 | 42 |
GO:00431238 | Endometrium | AEH | positive regulation of I-kappaB kinase/NF-kappaB signaling | 41/2100 | 186/18723 | 1.59e-05 | 3.32e-04 | 41 |
GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
GO:00703028 | Endometrium | AEH | regulation of stress-activated protein kinase signaling cascade | 42/2100 | 195/18723 | 2.27e-05 | 4.35e-04 | 42 |
GO:00072498 | Endometrium | AEH | I-kappaB kinase/NF-kappaB signaling | 55/2100 | 281/18723 | 2.60e-05 | 4.88e-04 | 55 |
GO:003461415 | Endometrium | AEH | cellular response to reactive oxygen species | 34/2100 | 155/18723 | 9.00e-05 | 1.30e-03 | 34 |
GO:00159319 | Endometrium | AEH | nucleobase-containing compound transport | 44/2100 | 222/18723 | 1.19e-04 | 1.66e-03 | 44 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513013 | Stomach | GC | Pathogenic Escherichia coli infection | 43/708 | 197/8465 | 2.99e-09 | 6.39e-08 | 4.50e-08 | 43 |
hsa0513213 | Stomach | GC | Salmonella infection | 42/708 | 249/8465 | 7.57e-06 | 1.05e-04 | 7.41e-05 | 42 |
hsa0516913 | Stomach | GC | Epstein-Barr virus infection | 33/708 | 202/8465 | 1.35e-04 | 1.31e-03 | 9.22e-04 | 33 |
hsa0513113 | Stomach | GC | Shigellosis | 36/708 | 247/8465 | 6.74e-04 | 5.42e-03 | 3.82e-03 | 36 |
hsa0516311 | Stomach | GC | Human cytomegalovirus infection | 33/708 | 225/8465 | 9.98e-04 | 7.42e-03 | 5.23e-03 | 33 |
hsa0517011 | Stomach | GC | Human immunodeficiency virus 1 infection | 30/708 | 212/8465 | 2.91e-03 | 1.76e-02 | 1.24e-02 | 30 |
hsa0513021 | Stomach | CAG with IM | Pathogenic Escherichia coli infection | 41/640 | 197/8465 | 1.58e-09 | 3.13e-08 | 2.20e-08 | 41 |
hsa0513221 | Stomach | CAG with IM | Salmonella infection | 42/640 | 249/8465 | 5.52e-07 | 9.75e-06 | 6.84e-06 | 42 |
hsa051692 | Stomach | CAG with IM | Epstein-Barr virus infection | 32/640 | 202/8465 | 4.57e-05 | 4.69e-04 | 3.29e-04 | 32 |
hsa0516321 | Stomach | CAG with IM | Human cytomegalovirus infection | 31/640 | 225/8465 | 7.66e-04 | 5.94e-03 | 4.17e-03 | 31 |
hsa0513121 | Stomach | CAG with IM | Shigellosis | 33/640 | 247/8465 | 9.05e-04 | 6.85e-03 | 4.81e-03 | 33 |
hsa0517021 | Stomach | CAG with IM | Human immunodeficiency virus 1 infection | 29/640 | 212/8465 | 1.26e-03 | 8.93e-03 | 6.27e-03 | 29 |
hsa051604 | Stomach | CAG with IM | Hepatitis C | 21/640 | 157/8465 | 7.26e-03 | 4.05e-02 | 2.84e-02 | 21 |
hsa0421710 | Stomach | CAG with IM | Necroptosis | 21/640 | 159/8465 | 8.37e-03 | 4.59e-02 | 3.22e-02 | 21 |
hsa0513031 | Stomach | CAG with IM | Pathogenic Escherichia coli infection | 41/640 | 197/8465 | 1.58e-09 | 3.13e-08 | 2.20e-08 | 41 |
hsa0513231 | Stomach | CAG with IM | Salmonella infection | 42/640 | 249/8465 | 5.52e-07 | 9.75e-06 | 6.84e-06 | 42 |
hsa051693 | Stomach | CAG with IM | Epstein-Barr virus infection | 32/640 | 202/8465 | 4.57e-05 | 4.69e-04 | 3.29e-04 | 32 |
hsa0516331 | Stomach | CAG with IM | Human cytomegalovirus infection | 31/640 | 225/8465 | 7.66e-04 | 5.94e-03 | 4.17e-03 | 31 |
hsa0513131 | Stomach | CAG with IM | Shigellosis | 33/640 | 247/8465 | 9.05e-04 | 6.85e-03 | 4.81e-03 | 33 |
hsa0517031 | Stomach | CAG with IM | Human immunodeficiency virus 1 infection | 29/640 | 212/8465 | 1.26e-03 | 8.93e-03 | 6.27e-03 | 29 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIPK1 | SNV | Missense_Mutation | | c.1237N>T | p.Arg413Cys | p.R413C | Q13546 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RIPK1 | SNV | Missense_Mutation | | c.919G>C | p.Glu307Gln | p.E307Q | Q13546 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RIPK1 | SNV | Missense_Mutation | | c.808N>T | p.Ala270Ser | p.A270S | Q13546 | protein_coding | tolerated(0.38) | benign(0.173) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
RIPK1 | SNV | Missense_Mutation | novel | c.1281N>C | p.Glu427Asp | p.E427D | Q13546 | protein_coding | tolerated(0.41) | benign(0) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIPK1 | SNV | Missense_Mutation | | c.439N>A | p.Asp147Asn | p.D147N | Q13546 | protein_coding | deleterious(0.03) | probably_damaging(0.987) | TCGA-E2-A152-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | PD |
RIPK1 | insertion | Frame_Shift_Ins | novel | c.1407_1408insGGTCCTGTGGAGGAGTCCTGGTTTGCTCCTTCCCTGG | p.Ser470GlyfsTer42 | p.S470Gfs*42 | Q13546 | protein_coding | | | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
RIPK1 | SNV | Missense_Mutation | | c.324N>C | p.Met108Ile | p.M108I | Q13546 | protein_coding | tolerated(0.62) | benign(0) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RIPK1 | SNV | Missense_Mutation | | c.1297G>A | p.Glu433Lys | p.E433K | Q13546 | protein_coding | tolerated(0.79) | benign(0.021) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RIPK1 | SNV | Missense_Mutation | rs748885856 | c.1571N>T | p.Pro524Leu | p.P524L | Q13546 | protein_coding | tolerated(0.12) | benign(0) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RIPK1 | deletion | Frame_Shift_Del | novel | c.1302delN | p.Gly436AlafsTer76 | p.G436Afs*76 | Q13546 | protein_coding | | | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 340590273 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565867 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178102513 | PONATINIB | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 384403680 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | RESVERATROL | RESVERATROL | 16116226 |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 336446940 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 354702223 | NECROSTATIN | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | GSK2982772 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 354702224 | | |
8737 | RIPK1 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 354702222 | | |