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Gene: PSMC3 |
Gene summary for PSMC3 |
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Gene information | Species | Human | Gene symbol | PSMC3 | Gene ID | 5702 |
Gene name | proteasome 26S subunit, ATPase 3 | |
Gene Alias | DCIDP | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A140VK42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5702 | PSMC3 | GSM4909281 | Human | Breast | IDC | 4.96e-02 | 2.22e-01 | 0.21 |
5702 | PSMC3 | GSM4909288 | Human | Breast | IDC | 2.74e-02 | 1.35e-01 | 0.0988 |
5702 | PSMC3 | GSM4909296 | Human | Breast | IDC | 1.21e-05 | -2.65e-02 | 0.1524 |
5702 | PSMC3 | GSM4909297 | Human | Breast | IDC | 2.51e-09 | -7.98e-02 | 0.1517 |
5702 | PSMC3 | GSM4909311 | Human | Breast | IDC | 2.23e-22 | -2.06e-01 | 0.1534 |
5702 | PSMC3 | GSM4909312 | Human | Breast | IDC | 2.10e-09 | -8.23e-02 | 0.1552 |
5702 | PSMC3 | GSM4909319 | Human | Breast | IDC | 2.77e-27 | -1.52e-01 | 0.1563 |
5702 | PSMC3 | GSM4909320 | Human | Breast | IDC | 3.12e-02 | -1.96e-01 | 0.1575 |
5702 | PSMC3 | GSM4909321 | Human | Breast | IDC | 2.97e-08 | -3.14e-03 | 0.1559 |
5702 | PSMC3 | brca1 | Human | Breast | Precancer | 6.32e-26 | 6.42e-01 | -0.0338 |
5702 | PSMC3 | brca2 | Human | Breast | Precancer | 2.29e-18 | 5.20e-01 | -0.024 |
5702 | PSMC3 | brca3 | Human | Breast | Precancer | 1.56e-03 | 1.62e-01 | -0.0263 |
5702 | PSMC3 | NCCBC14 | Human | Breast | DCIS | 6.14e-05 | -9.03e-02 | 0.2021 |
5702 | PSMC3 | NCCBC2 | Human | Breast | DCIS | 6.02e-04 | -2.43e-01 | 0.1554 |
5702 | PSMC3 | NCCBC5 | Human | Breast | DCIS | 1.08e-11 | 1.35e-01 | 0.2046 |
5702 | PSMC3 | P1 | Human | Breast | IDC | 2.29e-13 | -1.43e-01 | 0.1527 |
5702 | PSMC3 | P2 | Human | Breast | IDC | 1.03e-03 | 2.19e-01 | 0.21 |
5702 | PSMC3 | DCIS2 | Human | Breast | DCIS | 1.44e-50 | 1.29e-01 | 0.0085 |
5702 | PSMC3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.21e-11 | 2.34e-01 | -0.1808 |
5702 | PSMC3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.88e-11 | 3.37e-01 | -0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:19033629 | Breast | Precancer | regulation of cellular protein catabolic process | 36/1080 | 255/18723 | 6.03e-07 | 2.55e-05 | 36 |
GO:00421769 | Breast | Precancer | regulation of protein catabolic process | 47/1080 | 391/18723 | 1.50e-06 | 5.58e-05 | 47 |
GO:19030509 | Breast | Precancer | regulation of proteolysis involved in cellular protein catabolic process | 31/1080 | 221/18723 | 4.10e-06 | 1.27e-04 | 31 |
GO:00611369 | Breast | Precancer | regulation of proteasomal protein catabolic process | 24/1080 | 187/18723 | 1.99e-04 | 3.14e-03 | 24 |
GO:00431619 | Breast | Precancer | proteasome-mediated ubiquitin-dependent protein catabolic process | 42/1080 | 412/18723 | 2.49e-04 | 3.72e-03 | 42 |
GO:00098969 | Breast | Precancer | positive regulation of catabolic process | 48/1080 | 492/18723 | 2.62e-04 | 3.84e-03 | 48 |
GO:00313319 | Breast | Precancer | positive regulation of cellular catabolic process | 43/1080 | 427/18723 | 2.75e-04 | 4.00e-03 | 43 |
GO:19033649 | Breast | Precancer | positive regulation of cellular protein catabolic process | 20/1080 | 155/18723 | 6.10e-04 | 7.67e-03 | 20 |
GO:19030527 | Breast | Precancer | positive regulation of proteolysis involved in cellular protein catabolic process | 17/1080 | 133/18723 | 1.68e-03 | 1.70e-02 | 17 |
GO:00457329 | Breast | Precancer | positive regulation of protein catabolic process | 25/1080 | 231/18723 | 1.87e-03 | 1.82e-02 | 25 |
GO:19018007 | Breast | Precancer | positive regulation of proteasomal protein catabolic process | 15/1080 | 114/18723 | 2.31e-03 | 2.15e-02 | 15 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:004586214 | Breast | IDC | positive regulation of proteolysis | 66/1434 | 372/18723 | 9.76e-11 | 1.29e-08 | 66 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:004217614 | Breast | IDC | regulation of protein catabolic process | 63/1434 | 391/18723 | 1.32e-08 | 9.61e-07 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03050 | Colorectum | AD | Proteasome | 29/2092 | 46/8465 | 3.87e-08 | 6.18e-07 | 3.94e-07 | 29 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050201 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa030501 | Colorectum | AD | Proteasome | 29/2092 | 46/8465 | 3.87e-08 | 6.18e-07 | 3.94e-07 | 29 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050202 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa030502 | Colorectum | SER | Proteasome | 24/1580 | 46/8465 | 3.05e-07 | 5.96e-06 | 4.33e-06 | 24 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050203 | Colorectum | SER | Prion disease | 119/1580 | 273/8465 | 4.61e-22 | 3.06e-20 | 2.22e-20 | 119 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSMC3 | SNV | Missense_Mutation | novel | c.427N>C | p.Glu143Gln | p.E143Q | P17980 | protein_coding | tolerated(0.11) | benign(0.157) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PSMC3 | SNV | Missense_Mutation | c.149N>A | p.Ser50Asn | p.S50N | P17980 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PSMC3 | SNV | Missense_Mutation | c.874N>A | p.Gly292Ser | p.G292S | P17980 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A1HE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PSMC3 | SNV | Missense_Mutation | c.73N>A | p.Glu25Lys | p.E25K | P17980 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PSMC3 | SNV | Missense_Mutation | novel | c.532N>C | p.Asp178His | p.D178H | P17980 | protein_coding | deleterious(0.02) | probably_damaging(0.97) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
PSMC3 | SNV | Missense_Mutation | c.73N>A | p.Glu25Lys | p.E25K | P17980 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
PSMC3 | SNV | Missense_Mutation | rs771618920 | c.329A>G | p.Asn110Ser | p.N110S | P17980 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PSMC3 | SNV | Missense_Mutation | c.380N>T | p.Ser127Phe | p.S127F | P17980 | protein_coding | deleterious(0) | possibly_damaging(0.868) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
PSMC3 | SNV | Missense_Mutation | novel | c.375N>C | p.Lys125Asn | p.K125N | P17980 | protein_coding | deleterious(0.04) | possibly_damaging(0.535) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PSMC3 | SNV | Missense_Mutation | c.1178N>A | p.Gly393Glu | p.G393E | P17980 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5702 | PSMC3 | NA | inhibitor | BORTEZOMIB | BORTEZOMIB | |
5702 | PSMC3 | NA | inhibitor | CARFILZOMIB | CARFILZOMIB | |
5702 | PSMC3 | NA | inhibitor | CHEMBL2103884 | OPROZOMIB | |
5702 | PSMC3 | NA | inhibitor | CHEMBL451887 | CARFILZOMIB | |
5702 | PSMC3 | NA | BORTEZOMIB | BORTEZOMIB | 24524217 | |
5702 | PSMC3 | NA | inhibitor | CHEMBL325041 | BORTEZOMIB | |
5702 | PSMC3 | NA | CARFILZOMIB | CARFILZOMIB | 24524217 | |
5702 | PSMC3 | NA | inhibitor | CHEMBL3545432 | IXAZOMIB CITRATE |
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