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Gene: PLCB1 |
Gene summary for PLCB1 |
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Gene information | Species | Human | Gene symbol | PLCB1 | Gene ID | 23236 |
Gene name | phospholipase C beta 1 | |
Gene Alias | DEE12 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NQ66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23236 | PLCB1 | CCI_3 | Human | Cervix | CC | 3.51e-23 | 1.15e+00 | 0.516 |
23236 | PLCB1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.27e-06 | -3.11e-01 | 0.0155 |
23236 | PLCB1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.02e-04 | -4.51e-01 | -0.1808 |
23236 | PLCB1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.07e-02 | -3.80e-01 | -0.1088 |
23236 | PLCB1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.29e-09 | -4.72e-01 | -0.1954 |
23236 | PLCB1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.44e-08 | -3.34e-01 | -0.1001 |
23236 | PLCB1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.93e-03 | -2.88e-01 | -0.059 |
23236 | PLCB1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.11e-02 | -5.64e-01 | -0.0179 |
23236 | PLCB1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.98e-04 | -4.91e-01 | 0.0338 |
23236 | PLCB1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.38e-06 | -4.41e-01 | 0.0674 |
23236 | PLCB1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.35e-12 | -5.25e-01 | 0.294 |
23236 | PLCB1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.60e-07 | -3.80e-01 | 0.3859 |
23236 | PLCB1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.95e-03 | -5.37e-01 | 0.2585 |
23236 | PLCB1 | A001-C-207 | Human | Colorectum | FAP | 1.11e-10 | -5.25e-01 | 0.1278 |
23236 | PLCB1 | A015-C-203 | Human | Colorectum | FAP | 4.26e-15 | -5.28e-01 | -0.1294 |
23236 | PLCB1 | A015-C-204 | Human | Colorectum | FAP | 1.52e-02 | -3.79e-01 | -0.0228 |
23236 | PLCB1 | A002-C-201 | Human | Colorectum | FAP | 1.69e-10 | -4.77e-01 | 0.0324 |
23236 | PLCB1 | A002-C-203 | Human | Colorectum | FAP | 3.58e-03 | -3.70e-01 | 0.2786 |
23236 | PLCB1 | A001-C-108 | Human | Colorectum | FAP | 6.39e-08 | -4.00e-01 | -0.0272 |
23236 | PLCB1 | A002-C-021 | Human | Colorectum | FAP | 6.74e-03 | -3.54e-01 | 0.1171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:00975298 | Cervix | CC | myeloid leukocyte migration | 56/2311 | 220/18723 | 7.21e-08 | 4.15e-06 | 56 |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00018197 | Cervix | CC | positive regulation of cytokine production | 95/2311 | 467/18723 | 4.88e-07 | 1.85e-05 | 95 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:00509007 | Cervix | CC | leukocyte migration | 78/2311 | 369/18723 | 1.09e-06 | 3.80e-05 | 78 |
GO:00026857 | Cervix | CC | regulation of leukocyte migration | 50/2311 | 210/18723 | 2.95e-06 | 8.31e-05 | 50 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:20000453 | Cervix | CC | regulation of G1/S transition of mitotic cell cycle | 37/2311 | 142/18723 | 6.33e-06 | 1.53e-04 | 37 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
GO:00000824 | Cervix | CC | G1/S transition of mitotic cell cycle | 49/2311 | 214/18723 | 1.16e-05 | 2.48e-04 | 49 |
GO:19028062 | Cervix | CC | regulation of cell cycle G1/S phase transition | 41/2311 | 168/18723 | 1.18e-05 | 2.51e-04 | 41 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:19019903 | Cervix | CC | regulation of mitotic cell cycle phase transition | 63/2311 | 299/18723 | 1.27e-05 | 2.60e-04 | 63 |
GO:00716755 | Cervix | CC | regulation of mononuclear cell migration | 31/2311 | 115/18723 | 1.67e-05 | 3.22e-04 | 31 |
GO:00448434 | Cervix | CC | cell cycle G1/S phase transition | 53/2311 | 241/18723 | 1.76e-05 | 3.32e-04 | 53 |
GO:00459316 | Cervix | CC | positive regulation of mitotic cell cycle | 32/2311 | 121/18723 | 1.88e-05 | 3.47e-04 | 32 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04720 | Colorectum | AD | Long-term potentiation | 26/2092 | 67/8465 | 7.26e-03 | 2.97e-02 | 1.89e-02 | 26 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa047231 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa049611 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa054171 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa049121 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
hsa040711 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa047281 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa049711 | Colorectum | AD | Gastric acid secretion | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCB1 | SNV | Missense_Mutation | c.2245N>A | p.Val749Ile | p.V749I | Q9NQ66 | protein_coding | deleterious(0.02) | possibly_damaging(0.609) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
PLCB1 | SNV | Missense_Mutation | c.2548G>A | p.Glu850Lys | p.E850K | Q9NQ66 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PLCB1 | SNV | Missense_Mutation | c.978N>A | p.Phe326Leu | p.F326L | Q9NQ66 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLCB1 | SNV | Missense_Mutation | rs867281730 | c.1229N>T | p.Ser410Leu | p.S410L | Q9NQ66 | protein_coding | deleterious(0) | possibly_damaging(0.672) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCB1 | SNV | Missense_Mutation | c.662N>A | p.Pro221His | p.P221H | Q9NQ66 | protein_coding | tolerated(0.06) | possibly_damaging(0.593) | TCGA-AO-A0J2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PLCB1 | SNV | Missense_Mutation | novel | c.351G>T | p.Leu117Phe | p.L117F | Q9NQ66 | protein_coding | tolerated(0.15) | benign(0.385) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCB1 | SNV | Missense_Mutation | novel | c.352A>T | p.Asn118Tyr | p.N118Y | Q9NQ66 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCB1 | SNV | Missense_Mutation | novel | c.976T>C | p.Phe326Leu | p.F326L | Q9NQ66 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCB1 | SNV | Missense_Mutation | c.665G>A | p.Arg222Gln | p.R222Q | Q9NQ66 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-E2-A1LK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PLCB1 | SNV | Missense_Mutation | rs867281730 | c.1229N>T | p.Ser410Leu | p.S410L | Q9NQ66 | protein_coding | deleterious(0) | possibly_damaging(0.672) | TCGA-E2-A9RU-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23236 | PLCB1 | ENZYME, DRUGGABLE GENOME, PHOSPHOLIPASE | Selective serotonin reuptake inhibitors | 25649181 |
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