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Gene: GNAI1 |
Gene summary for GNAI1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GNAI1 | Gene ID | 2770 |
| Gene name | G protein subunit alpha i1 | |
| Gene Alias | Gi | |
| Cytomap | 7q21.11 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P63096 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2770 | GNAI1 | CA_HPV_1 | Human | Cervix | CC | 1.24e-03 | -1.26e-01 | 0.0264 |
| 2770 | GNAI1 | CA_HPV_3 | Human | Cervix | CC | 2.37e-02 | 1.85e-01 | 0.0414 |
| 2770 | GNAI1 | CCI_1 | Human | Cervix | CC | 4.78e-04 | 7.87e-01 | 0.528 |
| 2770 | GNAI1 | CCI_3 | Human | Cervix | CC | 7.00e-05 | 6.01e-01 | 0.516 |
| 2770 | GNAI1 | sample3 | Human | Cervix | CC | 2.03e-05 | 2.87e-01 | 0.1387 |
| 2770 | GNAI1 | T3 | Human | Cervix | CC | 2.19e-08 | 3.26e-01 | 0.1389 |
| 2770 | GNAI1 | LZE2T | Human | Esophagus | ESCC | 3.91e-03 | 2.41e-01 | 0.082 |
| 2770 | GNAI1 | LZE4T | Human | Esophagus | ESCC | 1.06e-11 | 2.98e-01 | 0.0811 |
| 2770 | GNAI1 | LZE8T | Human | Esophagus | ESCC | 6.50e-08 | 2.19e-01 | 0.067 |
| 2770 | GNAI1 | LZE20T | Human | Esophagus | ESCC | 3.29e-04 | 1.84e-01 | 0.0662 |
| 2770 | GNAI1 | LZE22D1 | Human | Esophagus | HGIN | 4.44e-02 | -2.37e-02 | 0.0595 |
| 2770 | GNAI1 | LZE6T | Human | Esophagus | ESCC | 3.76e-04 | 2.64e-02 | 0.0845 |
| 2770 | GNAI1 | P2T-E | Human | Esophagus | ESCC | 2.40e-16 | 2.08e-01 | 0.1177 |
| 2770 | GNAI1 | P4T-E | Human | Esophagus | ESCC | 1.39e-05 | 2.30e-01 | 0.1323 |
| 2770 | GNAI1 | P5T-E | Human | Esophagus | ESCC | 3.07e-12 | 2.58e-01 | 0.1327 |
| 2770 | GNAI1 | P8T-E | Human | Esophagus | ESCC | 1.39e-11 | 2.02e-01 | 0.0889 |
| 2770 | GNAI1 | P9T-E | Human | Esophagus | ESCC | 3.49e-05 | 1.77e-01 | 0.1131 |
| 2770 | GNAI1 | P10T-E | Human | Esophagus | ESCC | 5.90e-24 | 1.73e-01 | 0.116 |
| 2770 | GNAI1 | P11T-E | Human | Esophagus | ESCC | 2.41e-11 | 7.67e-01 | 0.1426 |
| 2770 | GNAI1 | P15T-E | Human | Esophagus | ESCC | 2.57e-18 | 4.66e-01 | 0.1149 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
| GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
| GO:19043779 | Cervix | CC | positive regulation of protein localization to cell periphery | 24/2311 | 69/18723 | 1.21e-06 | 4.15e-05 | 24 |
| GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
| GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
| GO:19043758 | Cervix | CC | regulation of protein localization to cell periphery | 30/2311 | 125/18723 | 2.28e-04 | 2.56e-03 | 30 |
| GO:00705074 | Cervix | CC | regulation of microtubule cytoskeleton organization | 32/2311 | 148/18723 | 1.02e-03 | 8.51e-03 | 32 |
| GO:00973059 | Cervix | CC | response to alcohol | 46/2311 | 253/18723 | 4.40e-03 | 2.69e-02 | 46 |
| GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
| GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
| GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
| GO:190437518 | Esophagus | HGIN | regulation of protein localization to cell periphery | 32/2587 | 125/18723 | 3.23e-04 | 5.39e-03 | 32 |
| GO:00070527 | Esophagus | HGIN | mitotic spindle organization | 31/2587 | 120/18723 | 3.35e-04 | 5.50e-03 | 31 |
| GO:19028507 | Esophagus | HGIN | microtubule cytoskeleton organization involved in mitosis | 36/2587 | 147/18723 | 3.61e-04 | 5.68e-03 | 36 |
| GO:00070518 | Esophagus | HGIN | spindle organization | 42/2587 | 184/18723 | 6.07e-04 | 8.49e-03 | 42 |
| GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
| GO:004343420 | Esophagus | HGIN | response to peptide hormone | 79/2587 | 414/18723 | 1.60e-03 | 1.79e-02 | 79 |
| GO:190437718 | Esophagus | HGIN | positive regulation of protein localization to cell periphery | 18/2587 | 69/18723 | 4.94e-03 | 4.18e-02 | 18 |
| GO:00902245 | Esophagus | HGIN | regulation of spindle organization | 12/2587 | 39/18723 | 4.97e-03 | 4.18e-02 | 12 |
| GO:00602365 | Esophagus | HGIN | regulation of mitotic spindle organization | 11/2587 | 35/18723 | 5.89e-03 | 4.78e-02 | 11 |
| Page: 1 2 3 4 5 6 7 8 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
| hsa0513314 | Esophagus | ESCC | Pertussis | 48/4205 | 76/8465 | 1.21e-02 | 2.77e-02 | 1.42e-02 | 48 |
| hsa0501214 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
| hsa05133 | Liver | Cirrhotic | Pertussis | 37/2530 | 76/8465 | 4.17e-04 | 2.57e-03 | 1.58e-03 | 37 |
| hsa0467022 | Liver | Cirrhotic | Leukocyte transendothelial migration | 49/2530 | 114/8465 | 1.92e-03 | 8.55e-03 | 5.27e-03 | 49 |
| hsa0516312 | Liver | Cirrhotic | Human cytomegalovirus infection | 87/2530 | 225/8465 | 2.67e-03 | 1.10e-02 | 6.76e-03 | 87 |
| hsa0514512 | Liver | Cirrhotic | Toxoplasmosis | 47/2530 | 112/8465 | 4.16e-03 | 1.63e-02 | 1.00e-02 | 47 |
| hsa0472314 | Liver | Cirrhotic | Retrograde endocannabinoid signaling | 57/2530 | 148/8465 | 1.45e-02 | 4.39e-02 | 2.71e-02 | 57 |
| hsa0501215 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
| hsa051331 | Liver | Cirrhotic | Pertussis | 37/2530 | 76/8465 | 4.17e-04 | 2.57e-03 | 1.58e-03 | 37 |
| hsa0467032 | Liver | Cirrhotic | Leukocyte transendothelial migration | 49/2530 | 114/8465 | 1.92e-03 | 8.55e-03 | 5.27e-03 | 49 |
| hsa0516313 | Liver | Cirrhotic | Human cytomegalovirus infection | 87/2530 | 225/8465 | 2.67e-03 | 1.10e-02 | 6.76e-03 | 87 |
| hsa0514513 | Liver | Cirrhotic | Toxoplasmosis | 47/2530 | 112/8465 | 4.16e-03 | 1.63e-02 | 1.00e-02 | 47 |
| hsa0472315 | Liver | Cirrhotic | Retrograde endocannabinoid signaling | 57/2530 | 148/8465 | 1.45e-02 | 4.39e-02 | 2.71e-02 | 57 |
| hsa0501222 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
| hsa051709 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
| hsa0516322 | Liver | HCC | Human cytomegalovirus infection | 131/4020 | 225/8465 | 6.86e-04 | 2.77e-03 | 1.54e-03 | 131 |
| hsa0514521 | Liver | HCC | Toxoplasmosis | 70/4020 | 112/8465 | 9.25e-04 | 3.52e-03 | 1.96e-03 | 70 |
| hsa051332 | Liver | HCC | Pertussis | 48/4020 | 76/8465 | 4.17e-03 | 1.27e-02 | 7.06e-03 | 48 |
| hsa040718 | Liver | HCC | Sphingolipid signaling pathway | 72/4020 | 121/8465 | 5.01e-03 | 1.47e-02 | 8.18e-03 | 72 |
| Page: 1 2 3 4 5 6 7 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GNAI1 | SNV | Missense_Mutation | rs142908338 | c.313C>T | p.Arg105Cys | p.R105C | P63096 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
| GNAI1 | SNV | Missense_Mutation | novel | c.1051T>G | p.Cys351Gly | p.C351G | P63096 | protein_coding | deleterious(0.01) | possibly_damaging(0.468) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GNAI1 | deletion | Frame_Shift_Del | novel | c.908delN | p.Gln304AsnfsTer36 | p.Q304Nfs*36 | P63096 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| GNAI1 | SNV | Missense_Mutation | c.601N>A | p.Val201Met | p.V201M | P63096 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| GNAI1 | SNV | Missense_Mutation | novel | c.190N>A | p.Glu64Lys | p.E64K | P63096 | protein_coding | deleterious(0.03) | benign(0.116) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| GNAI1 | SNV | Missense_Mutation | novel | c.752N>G | p.Asp251Gly | p.D251G | P63096 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| GNAI1 | SNV | Missense_Mutation | rs758691743 | c.314N>A | p.Arg105His | p.R105H | P63096 | protein_coding | tolerated(0.07) | possibly_damaging(0.621) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| GNAI1 | SNV | Missense_Mutation | c.659N>T | p.Ala220Val | p.A220V | P63096 | protein_coding | deleterious(0.01) | benign(0.191) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| GNAI1 | SNV | Missense_Mutation | novel | c.658G>A | p.Ala220Thr | p.A220T | P63096 | protein_coding | tolerated(0.05) | possibly_damaging(0.886) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GNAI1 | insertion | Frame_Shift_Ins | novel | c.720_720+1insA | p.Asn241LysfsTer5 | p.N241Kfs*5 | P63096 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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