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Gene: FTL |
Gene summary for FTL |
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Gene information | Species | Human | Gene symbol | FTL | Gene ID | 2512 |
Gene name | ferritin light chain | |
Gene Alias | LFTD | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | P02792 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2512 | FTL | GSM4909281 | Human | Breast | IDC | 1.20e-09 | 2.15e-01 | 0.21 |
2512 | FTL | GSM4909282 | Human | Breast | IDC | 6.41e-21 | -2.88e-01 | -0.0288 |
2512 | FTL | GSM4909287 | Human | Breast | IDC | 1.76e-03 | 1.40e-01 | 0.2057 |
2512 | FTL | GSM4909292 | Human | Breast | IDC | 2.09e-03 | 3.33e-01 | 0.1236 |
2512 | FTL | GSM4909293 | Human | Breast | IDC | 2.18e-31 | -2.99e-01 | 0.1581 |
2512 | FTL | GSM4909294 | Human | Breast | IDC | 1.52e-26 | 3.16e-01 | 0.2022 |
2512 | FTL | GSM4909295 | Human | Breast | IDC | 1.43e-03 | 2.16e-01 | 0.0898 |
2512 | FTL | GSM4909296 | Human | Breast | IDC | 1.14e-18 | -3.96e-01 | 0.1524 |
2512 | FTL | GSM4909297 | Human | Breast | IDC | 2.22e-09 | -3.55e-01 | 0.1517 |
2512 | FTL | GSM4909298 | Human | Breast | IDC | 1.48e-19 | -2.17e-01 | 0.1551 |
2512 | FTL | GSM4909299 | Human | Breast | IDC | 9.62e-13 | -1.86e-01 | 0.035 |
2512 | FTL | GSM4909300 | Human | Breast | IDC | 4.78e-05 | -2.81e-01 | 0.0334 |
2512 | FTL | GSM4909301 | Human | Breast | IDC | 2.48e-04 | 1.64e-01 | 0.1577 |
2512 | FTL | GSM4909302 | Human | Breast | IDC | 9.32e-05 | 1.32e-01 | 0.1545 |
2512 | FTL | GSM4909304 | Human | Breast | IDC | 5.43e-11 | 2.23e-01 | 0.1636 |
2512 | FTL | GSM4909305 | Human | Breast | IDC | 1.84e-02 | -1.16e-01 | 0.0436 |
2512 | FTL | GSM4909311 | Human | Breast | IDC | 4.90e-21 | -4.69e-01 | 0.1534 |
2512 | FTL | GSM4909312 | Human | Breast | IDC | 2.78e-09 | -2.71e-01 | 0.1552 |
2512 | FTL | GSM4909315 | Human | Breast | IDC | 1.90e-12 | 1.95e-01 | 0.21 |
2512 | FTL | GSM4909316 | Human | Breast | IDC | 1.64e-02 | 1.51e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512358 | Breast | Precancer | maintenance of location | 40/1080 | 327/18723 | 5.85e-06 | 1.71e-04 | 40 |
GO:00516519 | Breast | Precancer | maintenance of location in cell | 30/1080 | 214/18723 | 5.91e-06 | 1.71e-04 | 30 |
GO:00512383 | Breast | Precancer | sequestering of metal ion | 7/1080 | 16/18723 | 1.50e-05 | 3.71e-04 | 7 |
GO:00550767 | Breast | Precancer | transition metal ion homeostasis | 20/1080 | 138/18723 | 1.28e-04 | 2.24e-03 | 20 |
GO:00469165 | Breast | Precancer | cellular transition metal ion homeostasis | 17/1080 | 115/18723 | 3.15e-04 | 4.49e-03 | 17 |
GO:00550725 | Breast | Precancer | iron ion homeostasis | 12/1080 | 85/18723 | 3.41e-03 | 2.85e-02 | 12 |
GO:00068263 | Breast | Precancer | iron ion transport | 9/1080 | 58/18723 | 5.67e-03 | 4.08e-02 | 9 |
GO:00000412 | Breast | Precancer | transition metal ion transport | 13/1080 | 105/18723 | 7.35e-03 | 4.89e-02 | 13 |
GO:005165114 | Breast | IDC | maintenance of location in cell | 37/1434 | 214/18723 | 2.39e-06 | 9.35e-05 | 37 |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:005123811 | Breast | IDC | sequestering of metal ion | 7/1434 | 16/18723 | 9.40e-05 | 1.81e-03 | 7 |
GO:005507613 | Breast | IDC | transition metal ion homeostasis | 23/1434 | 138/18723 | 3.20e-04 | 4.79e-03 | 23 |
GO:004691612 | Breast | IDC | cellular transition metal ion homeostasis | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
GO:000682611 | Breast | IDC | iron ion transport | 11/1434 | 58/18723 | 4.10e-03 | 3.25e-02 | 11 |
GO:005507212 | Breast | IDC | iron ion homeostasis | 14/1434 | 85/18723 | 4.98e-03 | 3.77e-02 | 14 |
GO:005165123 | Breast | DCIS | maintenance of location in cell | 36/1390 | 214/18723 | 3.07e-06 | 1.02e-04 | 36 |
GO:005123523 | Breast | DCIS | maintenance of location | 47/1390 | 327/18723 | 9.55e-06 | 2.56e-04 | 47 |
GO:00512382 | Breast | DCIS | sequestering of metal ion | 7/1390 | 16/18723 | 7.70e-05 | 1.48e-03 | 7 |
GO:005507622 | Breast | DCIS | transition metal ion homeostasis | 23/1390 | 138/18723 | 2.04e-04 | 3.27e-03 | 23 |
GO:004691621 | Breast | DCIS | cellular transition metal ion homeostasis | 20/1390 | 115/18723 | 2.91e-04 | 4.27e-03 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04978 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049781 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049782 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa0421710 | Stomach | CAG with IM | Necroptosis | 21/640 | 159/8465 | 8.37e-03 | 4.59e-02 | 3.22e-02 | 21 |
hsa049783 | Stomach | CAG with IM | Mineral absorption | 12/640 | 60/8465 | 1.52e-03 | 1.01e-02 | 7.10e-03 | 12 |
hsa0421711 | Stomach | CAG with IM | Necroptosis | 21/640 | 159/8465 | 8.37e-03 | 4.59e-02 | 3.22e-02 | 21 |
hsa049784 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa042172 | Stomach | CSG | Necroptosis | 21/633 | 159/8465 | 7.42e-03 | 4.11e-02 | 2.96e-02 | 21 |
hsa049785 | Stomach | CSG | Mineral absorption | 11/633 | 60/8465 | 4.40e-03 | 2.53e-02 | 1.82e-02 | 11 |
hsa042173 | Stomach | CSG | Necroptosis | 21/633 | 159/8465 | 7.42e-03 | 4.11e-02 | 2.96e-02 | 21 |
hsa042174 | Stomach | CAG | Necroptosis | 17/368 | 159/8465 | 5.26e-04 | 4.61e-03 | 3.69e-03 | 17 |
hsa049786 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa042175 | Stomach | CAG | Necroptosis | 17/368 | 159/8465 | 5.26e-04 | 4.61e-03 | 3.69e-03 | 17 |
hsa049787 | Stomach | CAG | Mineral absorption | 8/368 | 60/8465 | 4.18e-03 | 2.94e-02 | 2.36e-02 | 8 |
hsa042176 | Stomach | WIM | Necroptosis | 15/284 | 159/8465 | 2.79e-04 | 3.01e-03 | 2.40e-03 | 15 |
hsa042177 | Stomach | WIM | Necroptosis | 15/284 | 159/8465 | 2.79e-04 | 3.01e-03 | 2.40e-03 | 15 |
hsa049788 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
hsa042178 | Stomach | SIM | Necroptosis | 18/465 | 159/8465 | 2.71e-03 | 1.83e-02 | 1.47e-02 | 18 |
hsa049789 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
hsa042179 | Stomach | SIM | Necroptosis | 18/465 | 159/8465 | 2.71e-03 | 1.83e-02 | 1.47e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FTL | SNV | Missense_Mutation | c.382N>A | p.Asp128Asn | p.D128N | P02792 | protein_coding | deleterious(0.03) | possibly_damaging(0.722) | TCGA-E2-A1B5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
FTL | SNV | Missense_Mutation | novel | c.383N>G | p.Asp128Gly | p.D128G | P02792 | protein_coding | deleterious(0.02) | possibly_damaging(0.792) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FTL | SNV | Missense_Mutation | c.31N>G | p.Thr11Ala | p.T11A | P02792 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FTL | SNV | Missense_Mutation | rs559631027 | c.265N>A | p.Glu89Lys | p.E89K | P02792 | protein_coding | deleterious(0.04) | possibly_damaging(0.463) | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FTL | SNV | Missense_Mutation | rs770196454 | c.247A>G | p.Lys83Glu | p.K83E | P02792 | protein_coding | tolerated(0.05) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FTL | SNV | Missense_Mutation | novel | c.502G>A | p.Glu168Lys | p.E168K | P02792 | protein_coding | tolerated(0.18) | benign(0.276) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FTL | SNV | Missense_Mutation | novel | c.174G>T | p.Glu58Asp | p.E58D | P02792 | protein_coding | deleterious(0.01) | benign(0.047) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FTL | insertion | Frame_Shift_Ins | novel | c.422_423insTATCA | p.Lys143IlefsTer9 | p.K143Ifs*9 | P02792 | protein_coding | TCGA-G4-6315-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
FTL | SNV | Missense_Mutation | novel | c.512N>T | p.Thr171Ile | p.T171I | P02792 | protein_coding | deleterious(0.02) | benign(0.104) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FTL | SNV | Missense_Mutation | novel | c.320N>C | p.Leu107Pro | p.L107P | P02792 | protein_coding | deleterious(0.03) | possibly_damaging(0.495) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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