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Gene: CRK |
Gene summary for CRK |
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Gene information | Species | Human | Gene symbol | CRK | Gene ID | 1398 |
Gene name | CRK proto-oncogene, adaptor protein | |
Gene Alias | CRKII | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A0S2Z3K9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1398 | CRK | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.52e-02 | -1.71e-01 | 0.0155 |
1398 | CRK | HTA11_347_2000001011 | Human | Colorectum | AD | 5.62e-11 | 5.00e-01 | -0.1954 |
1398 | CRK | HTA11_411_2000001011 | Human | Colorectum | SER | 8.31e-05 | 8.78e-01 | -0.2602 |
1398 | CRK | HTA11_83_2000001011 | Human | Colorectum | SER | 4.62e-02 | 4.63e-01 | -0.1526 |
1398 | CRK | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.13e-05 | 6.12e-01 | -0.059 |
1398 | CRK | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.79e-02 | -1.96e-01 | 0.3859 |
1398 | CRK | A002-C-010 | Human | Colorectum | FAP | 2.08e-02 | -2.13e-01 | 0.242 |
1398 | CRK | A001-C-207 | Human | Colorectum | FAP | 1.95e-04 | -3.53e-01 | 0.1278 |
1398 | CRK | A015-C-203 | Human | Colorectum | FAP | 1.71e-22 | -3.60e-01 | -0.1294 |
1398 | CRK | A015-C-204 | Human | Colorectum | FAP | 7.64e-04 | -2.70e-01 | -0.0228 |
1398 | CRK | A014-C-040 | Human | Colorectum | FAP | 2.14e-02 | -4.20e-01 | -0.1184 |
1398 | CRK | A002-C-201 | Human | Colorectum | FAP | 1.76e-06 | -2.31e-01 | 0.0324 |
1398 | CRK | A001-C-119 | Human | Colorectum | FAP | 8.38e-04 | -3.59e-01 | -0.1557 |
1398 | CRK | A001-C-108 | Human | Colorectum | FAP | 1.18e-12 | -3.04e-01 | -0.0272 |
1398 | CRK | A002-C-205 | Human | Colorectum | FAP | 2.60e-13 | -3.06e-01 | -0.1236 |
1398 | CRK | A001-C-104 | Human | Colorectum | FAP | 5.59e-03 | -2.08e-01 | 0.0184 |
1398 | CRK | A015-C-005 | Human | Colorectum | FAP | 2.05e-05 | -3.24e-01 | -0.0336 |
1398 | CRK | A015-C-006 | Human | Colorectum | FAP | 4.68e-10 | -4.21e-01 | -0.0994 |
1398 | CRK | A015-C-106 | Human | Colorectum | FAP | 8.27e-09 | -1.98e-01 | -0.0511 |
1398 | CRK | A002-C-114 | Human | Colorectum | FAP | 5.30e-10 | -2.53e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0010811 | Colorectum | AD | positive regulation of cell-substrate adhesion | 53/3918 | 123/18723 | 2.30e-08 | 1.27e-06 | 53 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:1990090 | Colorectum | AD | cellular response to nerve growth factor stimulus | 26/3918 | 53/18723 | 4.87e-06 | 1.28e-04 | 26 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:1990089 | Colorectum | AD | response to nerve growth factor | 26/3918 | 56/18723 | 1.71e-05 | 3.59e-04 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051355 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa047225 | Colorectum | MSS | Neurotrophin signaling pathway | 45/1875 | 119/8465 | 7.04e-05 | 6.55e-04 | 4.02e-04 | 45 |
hsa051635 | Colorectum | MSS | Human cytomegalovirus infection | 74/1875 | 225/8465 | 1.12e-04 | 1.01e-03 | 6.19e-04 | 74 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa049351 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa052203 | Colorectum | MSS | Chronic myeloid leukemia | 29/1875 | 76/8465 | 1.10e-03 | 6.27e-03 | 3.84e-03 | 29 |
hsa040123 | Colorectum | MSS | ErbB signaling pathway | 30/1875 | 85/8465 | 3.73e-03 | 1.67e-02 | 1.02e-02 | 30 |
hsa048105 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa049101 | Colorectum | MSS | Insulin signaling pathway | 43/1875 | 137/8465 | 7.37e-03 | 2.84e-02 | 1.74e-02 | 43 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051008 | Colorectum | FAP | Bacterial invasion of epithelial cells | 33/1404 | 77/8465 | 4.33e-08 | 1.11e-06 | 6.77e-07 | 33 |
hsa045102 | Colorectum | FAP | Focal adhesion | 61/1404 | 203/8465 | 1.03e-06 | 2.15e-05 | 1.31e-05 | 61 |
hsa046666 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa048106 | Colorectum | FAP | Regulation of actin cytoskeleton | 65/1404 | 229/8465 | 4.07e-06 | 5.91e-05 | 3.59e-05 | 65 |
hsa051356 | Colorectum | FAP | Yersinia infection | 43/1404 | 137/8465 | 1.21e-05 | 1.62e-04 | 9.86e-05 | 43 |
hsa047226 | Colorectum | FAP | Neurotrophin signaling pathway | 38/1404 | 119/8465 | 2.49e-05 | 2.78e-04 | 1.69e-04 | 38 |
hsa052112 | Colorectum | FAP | Renal cell carcinoma | 23/1404 | 69/8465 | 4.86e-04 | 3.56e-03 | 2.16e-03 | 23 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa049352 | Colorectum | FAP | Growth hormone synthesis, secretion and action | 34/1404 | 120/8465 | 8.12e-04 | 5.14e-03 | 3.13e-03 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRK | SNV | Missense_Mutation | novel | c.608N>A | p.Gly203Asp | p.G203D | P46108 | protein_coding | deleterious(0.03) | benign(0.006) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CRK | SNV | Missense_Mutation | novel | c.777G>T | p.Glu259Asp | p.E259D | P46108 | protein_coding | tolerated(0.07) | benign(0.118) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | SNV | Missense_Mutation | rs145983279 | c.562G>A | p.Glu188Lys | p.E188K | P46108 | protein_coding | deleterious(0.02) | benign(0.438) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CRK | SNV | Missense_Mutation | novel | c.795N>T | p.Lys265Asn | p.K265N | P46108 | protein_coding | deleterious(0.02) | probably_damaging(0.955) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CRK | SNV | Missense_Mutation | rs748897674 | c.686N>T | p.Pro229Leu | p.P229L | P46108 | protein_coding | deleterious(0.02) | benign(0.157) | TCGA-D1-A16R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | SNV | Missense_Mutation | novel | c.385N>A | p.Leu129Ile | p.L129I | P46108 | protein_coding | tolerated(0.23) | benign(0) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CRK | SNV | Missense_Mutation | novel | c.721N>G | p.Arg241Gly | p.R241G | P46108 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | deletion | Frame_Shift_Del | c.818delN | p.Gly273ValfsTer66 | p.G273Vfs*66 | P46108 | protein_coding | TCGA-55-7725-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CRK | SNV | Missense_Mutation | rs776920144 | c.559N>A | p.Val187Ile | p.V187I | P46108 | protein_coding | tolerated(0.09) | possibly_damaging(0.63) | TCGA-CN-5365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CRK | SNV | Missense_Mutation | c.172N>G | p.Ser58Ala | p.S58A | P46108 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CH-5748-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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