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Gene: ATP5J2 |
Gene summary for ATP5J2 |
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Gene information | Species | Human | Gene symbol | ATP5J2 | Gene ID | 9551 |
Gene name | ATP synthase membrane subunit f | |
Gene Alias | ATP5J2 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56134 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9551 | ATP5J2 | GSM4909281 | Human | Breast | IDC | 4.47e-24 | -3.91e-01 | 0.21 |
9551 | ATP5J2 | GSM4909282 | Human | Breast | IDC | 2.52e-23 | -3.91e-01 | -0.0288 |
9551 | ATP5J2 | GSM4909285 | Human | Breast | IDC | 5.96e-23 | -3.91e-01 | 0.21 |
9551 | ATP5J2 | GSM4909286 | Human | Breast | IDC | 5.96e-23 | -3.91e-01 | 0.1081 |
9551 | ATP5J2 | GSM4909287 | Human | Breast | IDC | 4.02e-18 | -3.91e-01 | 0.2057 |
9551 | ATP5J2 | GSM4909288 | Human | Breast | IDC | 8.02e-04 | -3.91e-01 | 0.0988 |
9551 | ATP5J2 | GSM4909289 | Human | Breast | IDC | 1.80e-02 | -3.91e-01 | 0.1064 |
9551 | ATP5J2 | GSM4909290 | Human | Breast | IDC | 7.88e-13 | -3.91e-01 | 0.2096 |
9551 | ATP5J2 | GSM4909291 | Human | Breast | IDC | 2.70e-10 | -3.91e-01 | 0.1753 |
9551 | ATP5J2 | GSM4909293 | Human | Breast | IDC | 5.96e-23 | -3.91e-01 | 0.1581 |
9551 | ATP5J2 | GSM4909294 | Human | Breast | IDC | 1.06e-23 | -3.91e-01 | 0.2022 |
9551 | ATP5J2 | GSM4909295 | Human | Breast | IDC | 5.68e-08 | -3.91e-01 | 0.0898 |
9551 | ATP5J2 | GSM4909296 | Human | Breast | IDC | 4.47e-24 | -3.91e-01 | 0.1524 |
9551 | ATP5J2 | GSM4909297 | Human | Breast | IDC | 2.52e-23 | -3.91e-01 | 0.1517 |
9551 | ATP5J2 | GSM4909298 | Human | Breast | IDC | 1.06e-23 | -3.91e-01 | 0.1551 |
9551 | ATP5J2 | GSM4909299 | Human | Breast | IDC | 3.31e-22 | -3.91e-01 | 0.035 |
9551 | ATP5J2 | GSM4909300 | Human | Breast | IDC | 5.69e-07 | -3.91e-01 | 0.0334 |
9551 | ATP5J2 | GSM4909301 | Human | Breast | IDC | 2.52e-23 | -3.91e-01 | 0.1577 |
9551 | ATP5J2 | GSM4909302 | Human | Breast | IDC | 7.44e-18 | -3.91e-01 | 0.1545 |
9551 | ATP5J2 | GSM4909303 | Human | Breast | IDC | 1.98e-04 | -3.91e-01 | 0.0438 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019021 | Stomach | CAG with IM | Oxidative phosphorylation | 49/640 | 134/8465 | 5.18e-22 | 3.29e-20 | 2.31e-20 | 49 |
hsa0471421 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0019031 | Stomach | CAG with IM | Oxidative phosphorylation | 49/640 | 134/8465 | 5.18e-22 | 3.29e-20 | 2.31e-20 | 49 |
hsa0471431 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0019041 | Stomach | CSG | Oxidative phosphorylation | 49/633 | 134/8465 | 3.19e-22 | 2.01e-20 | 1.45e-20 | 49 |
hsa0471441 | Stomach | CSG | Thermogenesis | 55/633 | 232/8465 | 4.36e-15 | 1.38e-13 | 9.91e-14 | 55 |
hsa0019051 | Stomach | CSG | Oxidative phosphorylation | 49/633 | 134/8465 | 3.19e-22 | 2.01e-20 | 1.45e-20 | 49 |
hsa0471451 | Stomach | CSG | Thermogenesis | 55/633 | 232/8465 | 4.36e-15 | 1.38e-13 | 9.91e-14 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5J2 | SNV | Missense_Mutation | c.275A>C | p.Lys92Thr | p.K92T | P56134 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP5J2 | SNV | Missense_Mutation | rs11545970 | c.128N>T | p.Ala43Val | p.A43V | P56134 | protein_coding | tolerated(0.06) | benign(0.358) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.50A>C | p.Lys17Thr | p.K17T | P56134 | protein_coding | deleterious(0.02) | possibly_damaging(0.461) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs762526939 | c.265C>T | p.Arg89Trp | p.R89W | P56134 | protein_coding | tolerated(0.06) | benign(0.125) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.17N>T | p.Glu6Val | p.E6V | P56134 | protein_coding | tolerated(0.25) | possibly_damaging(0.661) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.22N>T | p.Pro8Ser | p.P8S | P56134 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-56-8622-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs771516671 | c.149N>A | p.Arg50Gln | p.R50Q | P56134 | protein_coding | tolerated(0.32) | benign(0.015) | TCGA-D7-6520-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | epirubicin | SD |
ATP5J2 | SNV | Missense_Mutation | rs761746638 | c.220N>A | p.Val74Met | p.V74M | P56134 | protein_coding | tolerated(0.15) | benign(0.184) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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