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Gene: IL8 |
Gene summary for IL8 |
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Gene information | Species | Human | Gene symbol | IL8 | Gene ID | 3576 |
Gene name | C-X-C motif chemokine ligand 8 | |
Gene Alias | GCP-1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A024RDA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3576 | IL8 | Pt13.a | Human | Liver | HCC | 8.72e-28 | 8.15e-01 | 0.021 |
3576 | IL8 | Pt13.b | Human | Liver | HCC | 6.11e-48 | 1.19e+00 | 0.0251 |
3576 | IL8 | Pt13.c | Human | Liver | HCC | 6.11e-10 | 5.72e-01 | 0.0076 |
3576 | IL8 | Pt14.d | Human | Liver | HCC | 1.05e-09 | 3.67e-01 | 0.0143 |
3576 | IL8 | P1_S1_AK | Human | Skin | AK | 4.80e-27 | -8.45e-01 | -0.3399 |
3576 | IL8 | P2_S3_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3287 |
3576 | IL8 | P2_S4_SCCIS | Human | Skin | SCCIS | 2.83e-26 | -8.45e-01 | -0.3043 |
3576 | IL8 | P3_S6_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3256 |
3576 | IL8 | P4_S8_cSCC | Human | Skin | cSCC | 2.90e-18 | -8.45e-01 | -0.3095 |
3576 | IL8 | P5_S10_cSCC | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.299 |
3576 | IL8 | P1_cSCC | Human | Skin | cSCC | 1.05e-12 | -5.84e-01 | 0.0292 |
3576 | IL8 | P2_cSCC | Human | Skin | cSCC | 2.36e-14 | -6.43e-01 | -0.024 |
3576 | IL8 | P4_cSCC | Human | Skin | cSCC | 1.02e-06 | -6.85e-01 | -0.00290000000000005 |
3576 | IL8 | cSCC_p1 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.1916 |
3576 | IL8 | cSCC_p10 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2095 |
3576 | IL8 | cSCC_p11 | Human | Skin | cSCC | 1.97e-27 | -8.45e-01 | -0.2102 |
3576 | IL8 | cSCC_p3 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2085 |
3576 | IL8 | cSCC_p4 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2022 |
3576 | IL8 | cSCC_p6 | Human | Skin | cSCC | 1.17e-26 | -8.45e-01 | -0.1989 |
3576 | IL8 | cSCC_p7 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2332 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465710 | Stomach | SIM | IL-17 signaling pathway | 16/465 | 94/8465 | 4.58e-05 | 5.57e-04 | 4.47e-04 | 16 |
hsa053238 | Stomach | SIM | Rheumatoid arthritis | 13/465 | 93/8465 | 1.61e-03 | 1.28e-02 | 1.03e-02 | 13 |
hsa0516710 | Stomach | SIM | Kaposi sarcoma-associated herpesvirus infection | 21/465 | 194/8465 | 2.18e-03 | 1.54e-02 | 1.24e-02 | 21 |
hsa051648 | Stomach | SIM | Influenza A | 19/465 | 171/8465 | 2.59e-03 | 1.79e-02 | 1.44e-02 | 19 |
hsa05171111 | Stomach | SIM | Coronavirus disease - COVID-19 | 65/465 | 232/8465 | 1.47e-29 | 2.23e-27 | 1.79e-27 | 65 |
hsa0493211 | Stomach | SIM | Non-alcoholic fatty liver disease | 38/465 | 155/8465 | 1.79e-15 | 1.09e-13 | 8.74e-14 | 38 |
hsa0541711 | Stomach | SIM | Lipid and atherosclerosis | 34/465 | 215/8465 | 1.80e-08 | 4.20e-07 | 3.37e-07 | 34 |
hsa0513411 | Stomach | SIM | Legionellosis | 16/465 | 57/8465 | 3.81e-08 | 8.27e-07 | 6.64e-07 | 16 |
hsa05130111 | Stomach | SIM | Pathogenic Escherichia coli infection | 31/465 | 197/8465 | 8.76e-08 | 1.66e-06 | 1.34e-06 | 31 |
hsa05132111 | Stomach | SIM | Salmonella infection | 32/465 | 249/8465 | 5.48e-06 | 7.57e-05 | 6.08e-05 | 32 |
hsa0465711 | Stomach | SIM | IL-17 signaling pathway | 16/465 | 94/8465 | 4.58e-05 | 5.57e-04 | 4.47e-04 | 16 |
hsa053239 | Stomach | SIM | Rheumatoid arthritis | 13/465 | 93/8465 | 1.61e-03 | 1.28e-02 | 1.03e-02 | 13 |
hsa0516711 | Stomach | SIM | Kaposi sarcoma-associated herpesvirus infection | 21/465 | 194/8465 | 2.18e-03 | 1.54e-02 | 1.24e-02 | 21 |
hsa051649 | Stomach | SIM | Influenza A | 19/465 | 171/8465 | 2.59e-03 | 1.79e-02 | 1.44e-02 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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