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Gene: IL8 |
Gene summary for IL8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | IL8 | Gene ID | 3576 |
Gene name | C-X-C motif chemokine ligand 8 | |
Gene Alias | GCP-1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A024RDA5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3576 | IL8 | Pt13.a | Human | Liver | HCC | 8.72e-28 | 8.15e-01 | 0.021 |
3576 | IL8 | Pt13.b | Human | Liver | HCC | 6.11e-48 | 1.19e+00 | 0.0251 |
3576 | IL8 | Pt13.c | Human | Liver | HCC | 6.11e-10 | 5.72e-01 | 0.0076 |
3576 | IL8 | Pt14.d | Human | Liver | HCC | 1.05e-09 | 3.67e-01 | 0.0143 |
3576 | IL8 | P1_S1_AK | Human | Skin | AK | 4.80e-27 | -8.45e-01 | -0.3399 |
3576 | IL8 | P2_S3_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3287 |
3576 | IL8 | P2_S4_SCCIS | Human | Skin | SCCIS | 2.83e-26 | -8.45e-01 | -0.3043 |
3576 | IL8 | P3_S6_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3256 |
3576 | IL8 | P4_S8_cSCC | Human | Skin | cSCC | 2.90e-18 | -8.45e-01 | -0.3095 |
3576 | IL8 | P5_S10_cSCC | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.299 |
3576 | IL8 | P1_cSCC | Human | Skin | cSCC | 1.05e-12 | -5.84e-01 | 0.0292 |
3576 | IL8 | P2_cSCC | Human | Skin | cSCC | 2.36e-14 | -6.43e-01 | -0.024 |
3576 | IL8 | P4_cSCC | Human | Skin | cSCC | 1.02e-06 | -6.85e-01 | -0.00290000000000005 |
3576 | IL8 | cSCC_p1 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.1916 |
3576 | IL8 | cSCC_p10 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2095 |
3576 | IL8 | cSCC_p11 | Human | Skin | cSCC | 1.97e-27 | -8.45e-01 | -0.2102 |
3576 | IL8 | cSCC_p3 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2085 |
3576 | IL8 | cSCC_p4 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2022 |
3576 | IL8 | cSCC_p6 | Human | Skin | cSCC | 1.17e-26 | -8.45e-01 | -0.1989 |
3576 | IL8 | cSCC_p7 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2332 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513551 | Stomach | CSG | Yersinia infection | 20/633 | 137/8465 | 2.84e-03 | 1.84e-02 | 1.32e-02 | 20 |
hsa051463 | Stomach | CSG | Amoebiasis | 15/633 | 102/8465 | 8.50e-03 | 4.56e-02 | 3.28e-02 | 15 |
hsa0493261 | Stomach | CAG | Non-alcoholic fatty liver disease | 33/368 | 155/8465 | 1.26e-14 | 9.09e-13 | 7.28e-13 | 33 |
hsa0513061 | Stomach | CAG | Pathogenic Escherichia coli infection | 25/368 | 197/8465 | 1.26e-06 | 1.96e-05 | 1.57e-05 | 25 |
hsa0513261 | Stomach | CAG | Salmonella infection | 28/368 | 249/8465 | 3.34e-06 | 4.60e-05 | 3.69e-05 | 28 |
hsa0513161 | Stomach | CAG | Shigellosis | 21/368 | 247/8465 | 2.47e-03 | 1.79e-02 | 1.43e-02 | 21 |
hsa0493271 | Stomach | CAG | Non-alcoholic fatty liver disease | 33/368 | 155/8465 | 1.26e-14 | 9.09e-13 | 7.28e-13 | 33 |
hsa0513071 | Stomach | CAG | Pathogenic Escherichia coli infection | 25/368 | 197/8465 | 1.26e-06 | 1.96e-05 | 1.57e-05 | 25 |
hsa0513271 | Stomach | CAG | Salmonella infection | 28/368 | 249/8465 | 3.34e-06 | 4.60e-05 | 3.69e-05 | 28 |
hsa0513171 | Stomach | CAG | Shigellosis | 21/368 | 247/8465 | 2.47e-03 | 1.79e-02 | 1.43e-02 | 21 |
hsa0493281 | Stomach | WIM | Non-alcoholic fatty liver disease | 26/284 | 155/8465 | 7.39e-12 | 5.17e-10 | 4.12e-10 | 26 |
hsa0541781 | Stomach | WIM | Lipid and atherosclerosis | 28/284 | 215/8465 | 5.44e-10 | 1.90e-08 | 1.52e-08 | 28 |
hsa051348 | Stomach | WIM | Legionellosis | 13/284 | 57/8465 | 3.38e-08 | 8.60e-07 | 6.86e-07 | 13 |
hsa0513081 | Stomach | WIM | Pathogenic Escherichia coli infection | 22/284 | 197/8465 | 6.52e-07 | 1.07e-05 | 8.55e-06 | 22 |
hsa0513281 | Stomach | WIM | Salmonella infection | 25/284 | 249/8465 | 8.41e-07 | 1.31e-05 | 1.04e-05 | 25 |
hsa046578 | Stomach | WIM | IL-17 signaling pathway | 14/284 | 94/8465 | 2.60e-06 | 3.82e-05 | 3.05e-05 | 14 |
hsa051678 | Stomach | WIM | Kaposi sarcoma-associated herpesvirus infection | 19/284 | 194/8465 | 2.59e-05 | 3.02e-04 | 2.41e-04 | 19 |
hsa04621 | Stomach | WIM | NOD-like receptor signaling pathway | 15/284 | 186/8465 | 1.44e-03 | 1.30e-02 | 1.04e-02 | 15 |
hsa05120 | Stomach | WIM | Epithelial cell signaling in Helicobacter pylori infection | 8/284 | 70/8465 | 2.26e-03 | 1.92e-02 | 1.53e-02 | 8 |
hsa04064 | Stomach | WIM | NF-kappa B signaling pathway | 10/284 | 104/8465 | 2.49e-03 | 2.05e-02 | 1.63e-02 | 10 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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