Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TYK2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TYK2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TYK2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TYK2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034340 | Colorectum | AD | response to type I interferon | 22/3918 | 58/18723 | 2.23e-03 | 1.75e-02 | 22 |
GO:0060337 | Colorectum | AD | type I interferon signaling pathway | 19/3918 | 50/18723 | 4.23e-03 | 2.91e-02 | 19 |
GO:0071357 | Colorectum | AD | cellular response to type I interferon | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00343401 | Colorectum | SER | response to type I interferon | 17/2897 | 58/18723 | 5.50e-03 | 4.07e-02 | 17 |
GO:003434011 | Liver | HCC | response to type I interferon | 43/7958 | 58/18723 | 9.93e-07 | 1.50e-05 | 43 |
GO:006033711 | Liver | HCC | type I interferon signaling pathway | 37/7958 | 50/18723 | 6.13e-06 | 7.52e-05 | 37 |
GO:007135711 | Liver | HCC | cellular response to type I interferon | 38/7958 | 52/18723 | 7.59e-06 | 8.98e-05 | 38 |
GO:00343405 | Oral cavity | OSCC | response to type I interferon | 46/7305 | 58/18723 | 4.17e-10 | 1.11e-08 | 46 |
GO:00603374 | Oral cavity | OSCC | type I interferon signaling pathway | 41/7305 | 50/18723 | 5.59e-10 | 1.46e-08 | 41 |
GO:00713574 | Oral cavity | OSCC | cellular response to type I interferon | 42/7305 | 52/18723 | 8.50e-10 | 2.13e-08 | 42 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
GO:00182123 | Oral cavity | OSCC | peptidyl-tyrosine modification | 180/7305 | 378/18723 | 3.63e-04 | 2.22e-03 | 180 |
GO:00181083 | Oral cavity | OSCC | peptidyl-tyrosine phosphorylation | 177/7305 | 375/18723 | 6.86e-04 | 3.83e-03 | 177 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TYK2 | SNV | Missense_Mutation | | c.1327N>G | p.Leu443Val | p.L443V | P29597 | protein_coding | tolerated(0.91) | benign(0.052) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TYK2 | SNV | Missense_Mutation | | c.3157N>A | p.Glu1053Lys | p.E1053K | P29597 | protein_coding | tolerated(0.28) | possibly_damaging(0.496) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TYK2 | SNV | Missense_Mutation | novel | c.3055T>C | p.Tyr1019His | p.Y1019H | P29597 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TYK2 | SNV | Missense_Mutation | novel | c.274N>A | p.Glu92Lys | p.E92K | P29597 | protein_coding | tolerated(0.74) | benign(0.011) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
TYK2 | SNV | Missense_Mutation | | c.1309N>A | p.Glu437Lys | p.E437K | P29597 | protein_coding | deleterious(0) | possibly_damaging(0.641) | TCGA-BH-A1EO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TYK2 | SNV | Missense_Mutation | rs756802293 | c.2531N>C | p.Leu844Pro | p.L844P | P29597 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
TYK2 | insertion | In_Frame_Ins | novel | c.2267_2268insCCC | p.Lys756delinsAsnPro | p.K756delinsNP | P29597 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TYK2 | insertion | Frame_Shift_Ins | novel | c.1114_1115insTGGTGATTTTCATGGGACTGTGTGTT | p.Pro372LeufsTer26 | p.P372Lfs*26 | P29597 | protein_coding | | | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
TYK2 | SNV | Missense_Mutation | | c.345N>A | p.Met115Ile | p.M115I | P29597 | protein_coding | tolerated(0.06) | benign(0.045) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TYK2 | SNV | Missense_Mutation | novel | c.2554N>A | p.Glu852Lys | p.E852K | P29597 | protein_coding | deleterious(0.04) | possibly_damaging(0.593) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 178102342 | FEDRATINIB | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 315661321 | UPADACITINIB | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | PMID27774822-Compound-Figure9Example15 | | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | Pyrrolo-pyridone derivative 3 | | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | CHEMBL2103743 | TOFACITINIB CITRATE | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 405067336 | | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 385612218 | | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | Aminopyrimidine derivative 5 | | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 178102315 | RUXOLITINIB | |
7297 | TYK2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | PMID27774822-Compound-Figure3CompoundI-165 | | |