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Gene: SHFM1 |
Gene summary for SHFM1 |
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Gene information | Species | Human | Gene symbol | SHFM1 | Gene ID | 7979 |
Gene name | SEM1 26S proteasome subunit | |
Gene Alias | C7orf76 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P60896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7979 | SHFM1 | GSM4909280 | Human | Breast | Precancer | 2.58e-03 | -4.59e-01 | 0.0305 |
7979 | SHFM1 | GSM4909281 | Human | Breast | IDC | 9.92e-21 | -4.59e-01 | 0.21 |
7979 | SHFM1 | GSM4909282 | Human | Breast | IDC | 3.31e-22 | -4.59e-01 | -0.0288 |
7979 | SHFM1 | GSM4909285 | Human | Breast | IDC | 4.25e-21 | -4.59e-01 | 0.21 |
7979 | SHFM1 | GSM4909286 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.1081 |
7979 | SHFM1 | GSM4909287 | Human | Breast | IDC | 3.47e-27 | -4.59e-01 | 0.2057 |
7979 | SHFM1 | GSM4909288 | Human | Breast | IDC | 5.54e-07 | -4.59e-01 | 0.0988 |
7979 | SHFM1 | GSM4909289 | Human | Breast | IDC | 4.60e-05 | -4.59e-01 | 0.1064 |
7979 | SHFM1 | GSM4909290 | Human | Breast | IDC | 9.70e-20 | -4.59e-01 | 0.2096 |
7979 | SHFM1 | GSM4909291 | Human | Breast | IDC | 3.67e-16 | -4.59e-01 | 0.1753 |
7979 | SHFM1 | GSM4909292 | Human | Breast | IDC | 2.45e-02 | -4.59e-01 | 0.1236 |
7979 | SHFM1 | GSM4909293 | Human | Breast | IDC | 3.31e-22 | -4.59e-01 | 0.1581 |
7979 | SHFM1 | GSM4909294 | Human | Breast | IDC | 4.25e-21 | -4.59e-01 | 0.2022 |
7979 | SHFM1 | GSM4909295 | Human | Breast | IDC | 7.13e-13 | -4.59e-01 | 0.0898 |
7979 | SHFM1 | GSM4909296 | Human | Breast | IDC | 1.82e-21 | -4.59e-01 | 0.1524 |
7979 | SHFM1 | GSM4909297 | Human | Breast | IDC | 5.96e-23 | -4.59e-01 | 0.1517 |
7979 | SHFM1 | GSM4909298 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.1551 |
7979 | SHFM1 | GSM4909299 | Human | Breast | IDC | 2.31e-20 | -4.59e-01 | 0.035 |
7979 | SHFM1 | GSM4909300 | Human | Breast | IDC | 1.87e-11 | -4.59e-01 | 0.0334 |
7979 | SHFM1 | GSM4909301 | Human | Breast | IDC | 9.92e-21 | -4.59e-01 | 0.1577 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501443 | Breast | DCIS | Amyotrophic lateral sclerosis | 101/846 | 364/8465 | 7.14e-23 | 2.88e-21 | 2.12e-21 | 101 |
hsa0502243 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa0305042 | Breast | DCIS | Proteasome | 26/846 | 46/8465 | 5.46e-15 | 1.36e-13 | 9.99e-14 | 26 |
hsa0516941 | Breast | DCIS | Epstein-Barr virus infection | 46/846 | 202/8465 | 5.60e-08 | 1.13e-06 | 8.33e-07 | 46 |
hsa0501741 | Breast | DCIS | Spinocerebellar ataxia | 29/846 | 143/8465 | 1.52e-04 | 1.40e-03 | 1.03e-03 | 29 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502053 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0501653 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0501053 | Breast | DCIS | Alzheimer disease | 105/846 | 384/8465 | 3.23e-23 | 1.49e-21 | 1.10e-21 | 105 |
hsa0501453 | Breast | DCIS | Amyotrophic lateral sclerosis | 101/846 | 364/8465 | 7.14e-23 | 2.88e-21 | 2.12e-21 | 101 |
hsa0502253 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa0305052 | Breast | DCIS | Proteasome | 26/846 | 46/8465 | 5.46e-15 | 1.36e-13 | 9.99e-14 | 26 |
hsa0516951 | Breast | DCIS | Epstein-Barr virus infection | 46/846 | 202/8465 | 5.60e-08 | 1.13e-06 | 8.33e-07 | 46 |
hsa0501751 | Breast | DCIS | Spinocerebellar ataxia | 29/846 | 143/8465 | 1.52e-04 | 1.40e-03 | 1.03e-03 | 29 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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