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Gene: RRAS2 |
Gene summary for RRAS2 |
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Gene information | Species | Human | Gene symbol | RRAS2 | Gene ID | 22800 |
Gene name | RAS related 2 | |
Gene Alias | NS12 | |
Cytomap | 11p15.2 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P62070 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22800 | RRAS2 | LZE4T | Human | Esophagus | ESCC | 4.29e-04 | 3.85e-03 | 0.0811 |
22800 | RRAS2 | LZE20T | Human | Esophagus | ESCC | 1.79e-09 | 1.64e-01 | 0.0662 |
22800 | RRAS2 | LZE24T | Human | Esophagus | ESCC | 1.26e-20 | 4.60e-01 | 0.0596 |
22800 | RRAS2 | LZE21T | Human | Esophagus | ESCC | 2.85e-05 | 1.39e-01 | 0.0655 |
22800 | RRAS2 | P1T-E | Human | Esophagus | ESCC | 6.76e-03 | 1.22e-01 | 0.0875 |
22800 | RRAS2 | P2T-E | Human | Esophagus | ESCC | 4.59e-24 | 4.71e-01 | 0.1177 |
22800 | RRAS2 | P4T-E | Human | Esophagus | ESCC | 3.15e-27 | 5.39e-01 | 0.1323 |
22800 | RRAS2 | P5T-E | Human | Esophagus | ESCC | 2.31e-19 | 2.57e-01 | 0.1327 |
22800 | RRAS2 | P8T-E | Human | Esophagus | ESCC | 3.54e-13 | 3.92e-01 | 0.0889 |
22800 | RRAS2 | P9T-E | Human | Esophagus | ESCC | 2.54e-17 | 3.52e-01 | 0.1131 |
22800 | RRAS2 | P10T-E | Human | Esophagus | ESCC | 2.51e-24 | 3.98e-01 | 0.116 |
22800 | RRAS2 | P11T-E | Human | Esophagus | ESCC | 3.30e-13 | 6.60e-01 | 0.1426 |
22800 | RRAS2 | P12T-E | Human | Esophagus | ESCC | 1.52e-28 | 7.07e-01 | 0.1122 |
22800 | RRAS2 | P15T-E | Human | Esophagus | ESCC | 2.47e-24 | 5.64e-01 | 0.1149 |
22800 | RRAS2 | P16T-E | Human | Esophagus | ESCC | 1.53e-22 | 1.83e-01 | 0.1153 |
22800 | RRAS2 | P17T-E | Human | Esophagus | ESCC | 2.03e-11 | 7.96e-01 | 0.1278 |
22800 | RRAS2 | P19T-E | Human | Esophagus | ESCC | 5.49e-06 | 5.83e-01 | 0.1662 |
22800 | RRAS2 | P20T-E | Human | Esophagus | ESCC | 5.35e-18 | 4.19e-01 | 0.1124 |
22800 | RRAS2 | P21T-E | Human | Esophagus | ESCC | 2.22e-40 | 9.50e-01 | 0.1617 |
22800 | RRAS2 | P22T-E | Human | Esophagus | ESCC | 4.27e-25 | 3.83e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:007099712 | Liver | Cirrhotic | neuron death | 141/4634 | 361/18723 | 9.56e-10 | 4.38e-08 | 141 |
GO:19012147 | Liver | Cirrhotic | regulation of neuron death | 122/4634 | 319/18723 | 5.17e-08 | 1.62e-06 | 122 |
GO:000726511 | Liver | Cirrhotic | Ras protein signal transduction | 119/4634 | 337/18723 | 8.16e-06 | 1.22e-04 | 119 |
GO:00016495 | Liver | Cirrhotic | osteoblast differentiation | 80/4634 | 229/18723 | 3.39e-04 | 2.91e-03 | 80 |
GO:00015035 | Liver | Cirrhotic | ossification | 127/4634 | 408/18723 | 1.89e-03 | 1.19e-02 | 127 |
GO:007099722 | Liver | HCC | neuron death | 202/7958 | 361/18723 | 1.44e-07 | 2.70e-06 | 202 |
GO:190121412 | Liver | HCC | regulation of neuron death | 179/7958 | 319/18723 | 5.65e-07 | 9.01e-06 | 179 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:000164911 | Liver | HCC | osteoblast differentiation | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
GO:00072655 | Lung | IAC | Ras protein signal transduction | 65/2061 | 337/18723 | 4.48e-06 | 1.81e-04 | 65 |
GO:00709978 | Lung | IAC | neuron death | 68/2061 | 361/18723 | 6.32e-06 | 2.32e-04 | 68 |
GO:19012148 | Lung | IAC | regulation of neuron death | 58/2061 | 319/18723 | 8.28e-05 | 1.69e-03 | 58 |
GO:000726512 | Lung | AIS | Ras protein signal transduction | 60/1849 | 337/18723 | 4.68e-06 | 2.31e-04 | 60 |
GO:007099713 | Lung | AIS | neuron death | 58/1849 | 361/18723 | 1.39e-04 | 3.05e-03 | 58 |
GO:190121413 | Lung | AIS | regulation of neuron death | 50/1849 | 319/18723 | 6.90e-04 | 1.02e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520513 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0421813 | Lung | IAC | Cellular senescence | 40/1053 | 156/8465 | 4.44e-06 | 1.44e-04 | 9.59e-05 | 40 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0481013 | Lung | IAC | Regulation of actin cytoskeleton | 49/1053 | 229/8465 | 7.94e-05 | 1.17e-03 | 7.79e-04 | 49 |
hsa046251 | Lung | IAC | C-type lectin receptor signaling pathway | 26/1053 | 104/8465 | 3.15e-04 | 3.11e-03 | 2.06e-03 | 26 |
hsa0413715 | Lung | IAC | Mitophagy - animal | 19/1053 | 72/8465 | 9.72e-04 | 7.32e-03 | 4.86e-03 | 19 |
hsa0414012 | Lung | IAC | Autophagy - animal | 28/1053 | 141/8465 | 7.64e-03 | 3.03e-02 | 2.01e-02 | 28 |
hsa040721 | Lung | IAC | Phospholipase D signaling pathway | 28/1053 | 148/8465 | 1.46e-02 | 5.00e-02 | 3.32e-02 | 28 |
hsa0520522 | Lung | AIS | Proteoglycans in cancer | 52/961 | 205/8465 | 1.16e-08 | 5.38e-07 | 3.44e-07 | 52 |
hsa0481022 | Lung | AIS | Regulation of actin cytoskeleton | 47/961 | 229/8465 | 3.34e-05 | 5.62e-04 | 3.59e-04 | 47 |
hsa0421823 | Lung | AIS | Cellular senescence | 35/961 | 156/8465 | 5.09e-05 | 7.85e-04 | 5.03e-04 | 35 |
hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa0413722 | Lung | AIS | Mitophagy - animal | 18/961 | 72/8465 | 8.86e-04 | 7.11e-03 | 4.55e-03 | 18 |
hsa046252 | Lung | AIS | C-type lectin receptor signaling pathway | 22/961 | 104/8465 | 2.70e-03 | 1.59e-02 | 1.02e-02 | 22 |
hsa0414022 | Lung | AIS | Autophagy - animal | 26/961 | 141/8465 | 8.23e-03 | 3.71e-02 | 2.37e-02 | 26 |
hsa0520532 | Lung | AIS | Proteoglycans in cancer | 52/961 | 205/8465 | 1.16e-08 | 5.38e-07 | 3.44e-07 | 52 |
hsa0481032 | Lung | AIS | Regulation of actin cytoskeleton | 47/961 | 229/8465 | 3.34e-05 | 5.62e-04 | 3.59e-04 | 47 |
hsa0421833 | Lung | AIS | Cellular senescence | 35/961 | 156/8465 | 5.09e-05 | 7.85e-04 | 5.03e-04 | 35 |
hsa0401031 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa0413732 | Lung | AIS | Mitophagy - animal | 18/961 | 72/8465 | 8.86e-04 | 7.11e-03 | 4.55e-03 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRAS2 | insertion | Frame_Shift_Ins | novel | c.217_218insGTAGG | p.Glu73GlyfsTer8 | p.E73Gfs*8 | P62070 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
RRAS2 | SNV | Missense_Mutation | rs782490571 | c.349N>T | p.Arg117Cys | p.R117C | P62070 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RRAS2 | SNV | Missense_Mutation | novel | c.472N>A | p.Ala158Thr | p.A158T | P62070 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RRAS2 | SNV | Missense_Mutation | c.145N>T | p.Asp49Tyr | p.D49Y | P62070 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RRAS2 | SNV | Missense_Mutation | c.499G>A | p.Ala167Thr | p.A167T | P62070 | protein_coding | deleterious(0.03) | possibly_damaging(0.868) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RRAS2 | SNV | Missense_Mutation | c.144N>C | p.Glu48Asp | p.E48D | P62070 | protein_coding | deleterious(0) | possibly_damaging(0.762) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RRAS2 | SNV | Missense_Mutation | novel | c.583N>T | p.Asp195Tyr | p.D195Y | P62070 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RRAS2 | SNV | Missense_Mutation | rs113954997 | c.215A>T | p.Gln72Leu | p.Q72L | P62070 | protein_coding | deleterious(0) | possibly_damaging(0.717) | TCGA-AJ-A3EJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RRAS2 | SNV | Missense_Mutation | novel | c.334N>A | p.Leu112Ile | p.L112I | P62070 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RRAS2 | SNV | Missense_Mutation | rs782457908 | c.208N>A | p.Ala70Thr | p.A70T | P62070 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22800 | RRAS2 | NA | tamoxifen | TAMOXIFEN | 19047159 |
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