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Gene: RPS15A |
Gene summary for RPS15A |
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Gene information | Species | Human | Gene symbol | RPS15A | Gene ID | 6210 |
Gene name | ribosomal protein S15a | |
Gene Alias | DBA20 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | B2R4W8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6210 | RPS15A | GSM4909281 | Human | Breast | IDC | 3.61e-33 | -2.59e-01 | 0.21 |
6210 | RPS15A | GSM4909285 | Human | Breast | IDC | 1.27e-06 | -1.12e-01 | 0.21 |
6210 | RPS15A | GSM4909286 | Human | Breast | IDC | 1.94e-03 | -6.89e-02 | 0.1081 |
6210 | RPS15A | GSM4909287 | Human | Breast | IDC | 1.62e-32 | -3.62e-01 | 0.2057 |
6210 | RPS15A | GSM4909292 | Human | Breast | IDC | 1.07e-03 | -3.45e-01 | 0.1236 |
6210 | RPS15A | GSM4909295 | Human | Breast | IDC | 1.16e-08 | -2.73e-01 | 0.0898 |
6210 | RPS15A | GSM4909296 | Human | Breast | IDC | 5.28e-05 | 1.14e-01 | 0.1524 |
6210 | RPS15A | GSM4909298 | Human | Breast | IDC | 6.91e-05 | 1.12e-01 | 0.1551 |
6210 | RPS15A | GSM4909306 | Human | Breast | IDC | 3.15e-09 | 1.28e-01 | 0.1564 |
6210 | RPS15A | GSM4909311 | Human | Breast | IDC | 2.78e-02 | 7.00e-02 | 0.1534 |
6210 | RPS15A | GSM4909317 | Human | Breast | IDC | 1.00e-09 | -1.70e-01 | 0.1355 |
6210 | RPS15A | GSM4909319 | Human | Breast | IDC | 2.09e-11 | -2.90e-01 | 0.1563 |
6210 | RPS15A | GSM4909321 | Human | Breast | IDC | 4.39e-02 | -1.10e-01 | 0.1559 |
6210 | RPS15A | brca1 | Human | Breast | Precancer | 2.68e-33 | -2.07e-01 | -0.0338 |
6210 | RPS15A | brca2 | Human | Breast | Precancer | 3.54e-56 | -3.22e-01 | -0.024 |
6210 | RPS15A | brca3 | Human | Breast | Precancer | 5.76e-34 | -2.34e-01 | -0.0263 |
6210 | RPS15A | M2 | Human | Breast | IDC | 9.19e-09 | -4.28e-01 | 0.21 |
6210 | RPS15A | M5 | Human | Breast | IDC | 3.60e-03 | -3.55e-01 | 0.1598 |
6210 | RPS15A | NCCBC14 | Human | Breast | DCIS | 5.42e-29 | -4.97e-01 | 0.2021 |
6210 | RPS15A | NCCBC3 | Human | Breast | DCIS | 3.00e-13 | -1.46e-01 | 0.1198 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000961512 | Breast | DCIS | response to virus | 45/1390 | 367/18723 | 6.16e-04 | 7.82e-03 | 45 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00457871 | Colorectum | MSS | positive regulation of cell cycle | 80/3467 | 313/18723 | 1.15e-03 | 1.12e-02 | 80 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:0009615 | Colorectum | MSI-H | response to virus | 40/1319 | 367/18723 | 3.99e-03 | 4.61e-02 | 40 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:00457877 | Endometrium | AEH | positive regulation of cell cycle | 56/2100 | 313/18723 | 2.73e-04 | 3.14e-03 | 56 |
GO:00096159 | Endometrium | AEH | response to virus | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301027 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0517127 | Endometrium | EEC | Coronavirus disease - COVID-19 | 99/1237 | 232/8465 | 7.43e-26 | 4.89e-24 | 3.65e-24 | 99 |
hsa0301036 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0517136 | Endometrium | EEC | Coronavirus disease - COVID-19 | 99/1237 | 232/8465 | 7.43e-26 | 4.89e-24 | 3.65e-24 | 99 |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa0517139 | Esophagus | HGIN | Coronavirus disease - COVID-19 | 105/1383 | 232/8465 | 7.84e-26 | 5.11e-24 | 4.06e-24 | 105 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa05171115 | Esophagus | HGIN | Coronavirus disease - COVID-19 | 105/1383 | 232/8465 | 7.84e-26 | 5.11e-24 | 4.06e-24 | 105 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa05171211 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa05171310 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa0517114 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa0301014 | Liver | NAFLD | Ribosome | 80/1043 | 167/8465 | 3.12e-30 | 5.12e-28 | 4.12e-28 | 80 |
hsa0517115 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa0301015 | Liver | NAFLD | Ribosome | 80/1043 | 167/8465 | 3.12e-30 | 5.12e-28 | 4.12e-28 | 80 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS15A | SNV | Missense_Mutation | c.8N>A | p.Arg3His | p.R3H | P62244 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS15A | SNV | Missense_Mutation | c.126G>A | p.Met42Ile | p.M42I | P62244 | protein_coding | deleterious(0.03) | benign(0.049) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPS15A | SNV | Missense_Mutation | novel | c.273N>G | p.Asn91Lys | p.N91K | P62244 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPS15A | SNV | Missense_Mutation | rs564888848 | c.353N>A | p.Arg118Gln | p.R118Q | P62244 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
RPS15A | SNV | Missense_Mutation | novel | c.372N>C | p.Lys124Asn | p.K124N | P62244 | protein_coding | deleterious(0.03) | benign(0.347) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS15A | SNV | Missense_Mutation | c.142N>C | p.Gly48Arg | p.G48R | P62244 | protein_coding | deleterious(0) | benign(0.045) | TCGA-4B-A93V-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RPS15A | SNV | Missense_Mutation | novel | c.238N>A | p.Asp80Asn | p.D80N | P62244 | protein_coding | tolerated(0.17) | benign(0.045) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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