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Gene: PPP1R12B |
Gene summary for PPP1R12B |
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Gene information | Species | Human | Gene symbol | PPP1R12B | Gene ID | 4660 |
Gene name | protein phosphatase 1 regulatory subunit 12B | |
Gene Alias | MYPT2 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O60237 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4660 | PPP1R12B | CCI_1 | Human | Cervix | CC | 1.46e-11 | 1.21e+00 | 0.528 |
4660 | PPP1R12B | CCI_3 | Human | Cervix | CC | 1.12e-28 | 1.74e+00 | 0.516 |
4660 | PPP1R12B | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.00e-26 | -6.78e-01 | 0.0155 |
4660 | PPP1R12B | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.82e-05 | -9.59e-01 | 0.0216 |
4660 | PPP1R12B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.44e-11 | 6.31e-01 | -0.1954 |
4660 | PPP1R12B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.16e-12 | -6.47e-01 | -0.1207 |
4660 | PPP1R12B | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.72e-03 | -9.06e-01 | -0.00410000000000005 |
4660 | PPP1R12B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.63e-03 | -4.73e-01 | 0.096 |
4660 | PPP1R12B | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.76e-05 | -5.45e-01 | 0.0528 |
4660 | PPP1R12B | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.38e-16 | -7.26e-01 | 0.0338 |
4660 | PPP1R12B | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.77e-08 | -4.96e-01 | 0.0674 |
4660 | PPP1R12B | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.50e-03 | -4.84e-01 | -0.0124 |
4660 | PPP1R12B | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.46e-05 | -5.18e-01 | 0.0588 |
4660 | PPP1R12B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.76e-10 | -4.45e-01 | 0.294 |
4660 | PPP1R12B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.08e-13 | -5.52e-01 | 0.3859 |
4660 | PPP1R12B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.72e-13 | -8.95e-01 | 0.2585 |
4660 | PPP1R12B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.06e-47 | -9.40e-01 | 0.3005 |
4660 | PPP1R12B | A001-C-207 | Human | Colorectum | FAP | 9.75e-05 | -4.19e-01 | 0.1278 |
4660 | PPP1R12B | A015-C-203 | Human | Colorectum | FAP | 9.00e-45 | -8.30e-01 | -0.1294 |
4660 | PPP1R12B | A015-C-204 | Human | Colorectum | FAP | 5.77e-11 | -6.09e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00902578 | Cervix | CC | regulation of muscle system process | 45/2311 | 252/18723 | 6.73e-03 | 3.70e-02 | 45 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:00902571 | Colorectum | SER | regulation of muscle system process | 60/2897 | 252/18723 | 3.28e-04 | 5.22e-03 | 60 |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:00902572 | Colorectum | MSS | regulation of muscle system process | 66/3467 | 252/18723 | 1.55e-03 | 1.41e-02 | 66 |
GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
GO:00902574 | Colorectum | FAP | regulation of muscle system process | 58/2622 | 252/18723 | 7.22e-05 | 1.33e-03 | 58 |
GO:00030122 | Colorectum | FAP | muscle system process | 89/2622 | 452/18723 | 4.63e-04 | 5.39e-03 | 89 |
GO:00069371 | Colorectum | FAP | regulation of muscle contraction | 37/2622 | 169/18723 | 3.39e-03 | 2.47e-02 | 37 |
GO:00902575 | Colorectum | CRC | regulation of muscle system process | 51/2078 | 252/18723 | 1.49e-05 | 4.63e-04 | 51 |
GO:00030123 | Colorectum | CRC | muscle system process | 74/2078 | 452/18723 | 3.92e-04 | 5.80e-03 | 74 |
GO:00069372 | Colorectum | CRC | regulation of muscle contraction | 33/2078 | 169/18723 | 8.65e-04 | 1.07e-02 | 33 |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
GO:00902577 | Lung | IAC | regulation of muscle system process | 43/2061 | 252/18723 | 2.35e-03 | 2.28e-02 | 43 |
GO:000301211 | Lung | AIS | muscle system process | 63/1849 | 452/18723 | 3.18e-03 | 3.05e-02 | 63 |
GO:00030128 | Oral cavity | EOLP | muscle system process | 71/2218 | 452/18723 | 7.83e-03 | 3.73e-02 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481011 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0451011 | Liver | NAFLD | Focal adhesion | 38/1043 | 203/8465 | 5.13e-03 | 4.43e-02 | 3.57e-02 | 38 |
hsa0451021 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0520510 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0451031 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0520511 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa045108 | Lung | IAC | Focal adhesion | 59/1053 | 203/8465 | 1.31e-10 | 1.06e-08 | 7.06e-09 | 59 |
hsa0520512 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0481012 | Lung | IAC | Regulation of actin cytoskeleton | 49/1053 | 229/8465 | 7.94e-05 | 1.17e-03 | 7.79e-04 | 49 |
hsa04921 | Lung | IAC | Oxytocin signaling pathway | 33/1053 | 154/8465 | 1.09e-03 | 7.82e-03 | 5.19e-03 | 33 |
hsa0451012 | Lung | IAC | Focal adhesion | 59/1053 | 203/8465 | 1.31e-10 | 1.06e-08 | 7.06e-09 | 59 |
hsa0520513 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R12B | SNV | Missense_Mutation | novel | c.754A>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
PPP1R12B | SNV | Missense_Mutation | novel | c.754A>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PPP1R12B | SNV | Missense_Mutation | novel | c.754N>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPP1R12B | SNV | Missense_Mutation | rs368051793 | c.926G>A | p.Arg309Gln | p.R309Q | protein_coding | deleterious(0.03) | benign(0.412) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPP1R12B | SNV | Missense_Mutation | novel | c.2111N>A | p.Arg704Gln | p.R704Q | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
PPP1R12B | SNV | Missense_Mutation | novel | c.754N>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PPP1R12B | SNV | Missense_Mutation | novel | c.754N>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PPP1R12B | SNV | Missense_Mutation | novel | c.754N>G | p.Thr252Ala | p.T252A | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
PPP1R12B | SNV | Missense_Mutation | c.1639N>C | p.Ser547Pro | p.S547P | protein_coding | tolerated(0.07) | benign(0.026) | TCGA-E2-A1IF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
PPP1R12B | insertion | Frame_Shift_Ins | novel | c.465_466insAGTGATCTGCCCACCTCAGCCTCCCAAAG | p.Glu156SerfsTer24 | p.E156Sfs*24 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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