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Gene: POLR2F |
Gene summary for POLR2F |
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Gene information | Species | Human | Gene symbol | POLR2F | Gene ID | 5435 |
Gene name | RNA polymerase II, I and III subunit F | |
Gene Alias | HRBP14.4 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B0QYL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5435 | POLR2F | GSM4909281 | Human | Breast | IDC | 6.54e-25 | 6.48e-01 | 0.21 |
5435 | POLR2F | GSM4909282 | Human | Breast | IDC | 1.60e-04 | 3.38e-01 | -0.0288 |
5435 | POLR2F | GSM4909285 | Human | Breast | IDC | 2.20e-04 | 2.51e-01 | 0.21 |
5435 | POLR2F | GSM4909286 | Human | Breast | IDC | 2.68e-40 | 7.56e-01 | 0.1081 |
5435 | POLR2F | GSM4909290 | Human | Breast | IDC | 7.71e-08 | 3.52e-01 | 0.2096 |
5435 | POLR2F | GSM4909293 | Human | Breast | IDC | 2.02e-02 | -2.08e-01 | 0.1581 |
5435 | POLR2F | GSM4909294 | Human | Breast | IDC | 7.84e-04 | -1.22e-01 | 0.2022 |
5435 | POLR2F | GSM4909296 | Human | Breast | IDC | 1.62e-10 | -1.41e-01 | 0.1524 |
5435 | POLR2F | GSM4909297 | Human | Breast | IDC | 4.93e-15 | -4.04e-02 | 0.1517 |
5435 | POLR2F | GSM4909307 | Human | Breast | IDC | 3.03e-02 | 2.75e-01 | 0.1569 |
5435 | POLR2F | GSM4909308 | Human | Breast | IDC | 1.31e-05 | 2.64e-01 | 0.158 |
5435 | POLR2F | GSM4909309 | Human | Breast | IDC | 3.16e-05 | 2.05e-01 | 0.0483 |
5435 | POLR2F | GSM4909311 | Human | Breast | IDC | 1.98e-36 | -8.76e-02 | 0.1534 |
5435 | POLR2F | GSM4909312 | Human | Breast | IDC | 8.81e-17 | -2.11e-02 | 0.1552 |
5435 | POLR2F | GSM4909313 | Human | Breast | IDC | 3.69e-03 | 8.25e-03 | 0.0391 |
5435 | POLR2F | GSM4909319 | Human | Breast | IDC | 1.62e-44 | -2.36e-01 | 0.1563 |
5435 | POLR2F | GSM4909320 | Human | Breast | IDC | 2.17e-10 | 4.17e-02 | 0.1575 |
5435 | POLR2F | GSM4909321 | Human | Breast | IDC | 1.16e-16 | -5.08e-02 | 0.1559 |
5435 | POLR2F | brca2 | Human | Breast | Precancer | 4.93e-02 | 2.09e-01 | -0.024 |
5435 | POLR2F | M2 | Human | Breast | IDC | 3.54e-02 | -5.27e-02 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0302011 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa0501629 | Oral cavity | LP | Huntington disease | 172/2418 | 306/8465 | 6.31e-25 | 5.25e-23 | 3.39e-23 | 172 |
hsa0342021 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030202 | Oral cavity | LP | RNA polymerase | 18/2418 | 34/8465 | 2.35e-03 | 1.03e-02 | 6.63e-03 | 18 |
hsa046232 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa0501637 | Oral cavity | LP | Huntington disease | 172/2418 | 306/8465 | 6.31e-25 | 5.25e-23 | 3.39e-23 | 172 |
hsa0342031 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030203 | Oral cavity | LP | RNA polymerase | 18/2418 | 34/8465 | 2.35e-03 | 1.03e-02 | 6.63e-03 | 18 |
hsa046233 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa0501626 | Prostate | BPH | Huntington disease | 149/1718 | 306/8465 | 8.82e-30 | 7.27e-28 | 4.50e-28 | 149 |
hsa05016111 | Prostate | BPH | Huntington disease | 149/1718 | 306/8465 | 8.82e-30 | 7.27e-28 | 4.50e-28 | 149 |
hsa0501627 | Prostate | Tumor | Huntington disease | 150/1791 | 306/8465 | 2.72e-28 | 2.25e-26 | 1.40e-26 | 150 |
hsa0501636 | Prostate | Tumor | Huntington disease | 150/1791 | 306/8465 | 2.72e-28 | 2.25e-26 | 1.40e-26 | 150 |
hsa0501612 | Stomach | GC | Huntington disease | 69/708 | 306/8465 | 6.71e-15 | 2.68e-13 | 1.89e-13 | 69 |
hsa0501613 | Stomach | GC | Huntington disease | 69/708 | 306/8465 | 6.71e-15 | 2.68e-13 | 1.89e-13 | 69 |
hsa0501621 | Stomach | CAG with IM | Huntington disease | 68/640 | 306/8465 | 1.31e-16 | 5.21e-15 | 3.66e-15 | 68 |
hsa0501631 | Stomach | CAG with IM | Huntington disease | 68/640 | 306/8465 | 1.31e-16 | 5.21e-15 | 3.66e-15 | 68 |
hsa0501641 | Stomach | CSG | Huntington disease | 68/633 | 306/8465 | 7.35e-17 | 2.90e-15 | 2.09e-15 | 68 |
hsa0501651 | Stomach | CSG | Huntington disease | 68/633 | 306/8465 | 7.35e-17 | 2.90e-15 | 2.09e-15 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2F | SNV | Missense_Mutation | c.12C>A | p.Asn4Lys | p.N4K | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.834) | TCGA-AN-A0XT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | rs763720250 | c.206G>A | p.Arg69Gln | p.R69Q | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
POLR2F | SNV | Missense_Mutation | rs759220077 | c.109N>A | p.Glu37Lys | p.E37K | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
POLR2F | SNV | Missense_Mutation | rs778818192 | c.461G>A | p.Arg154Gln | p.R154Q | protein_coding | unknown(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | rs771399849 | c.85N>A | p.Glu29Lys | p.E29K | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
POLR2F | SNV | Missense_Mutation | rs760223334 | c.193N>A | p.Val65Met | p.V65M | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
POLR2F | SNV | Missense_Mutation | c.190N>T | p.Arg64Cys | p.R64C | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
POLR2F | insertion | Frame_Shift_Ins | novel | c.116_117insC | p.Ser41LeufsTer? | p.S41Lfs*? | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
POLR2F | SNV | Missense_Mutation | novel | c.469G>C | p.Glu157Gln | p.E157Q | protein_coding | unknown(0) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | novel | c.266N>A | p.Pro89His | p.P89H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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