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Gene: PIP5K1A |
Gene summary for PIP5K1A |
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Gene information | Species | Human | Gene symbol | PIP5K1A | Gene ID | 8394 |
Gene name | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha | |
Gene Alias | PIP5K1A | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | Q99755 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8394 | PIP5K1A | CCI_1 | Human | Cervix | CC | 4.19e-16 | 1.30e+00 | 0.528 |
8394 | PIP5K1A | CCI_2 | Human | Cervix | CC | 1.22e-10 | 9.96e-01 | 0.5249 |
8394 | PIP5K1A | CCI_3 | Human | Cervix | CC | 5.90e-26 | 1.20e+00 | 0.516 |
8394 | PIP5K1A | AEH-subject1 | Human | Endometrium | AEH | 1.96e-11 | 4.84e-01 | -0.3059 |
8394 | PIP5K1A | AEH-subject2 | Human | Endometrium | AEH | 1.07e-03 | 2.20e-01 | -0.2525 |
8394 | PIP5K1A | AEH-subject3 | Human | Endometrium | AEH | 1.70e-06 | 2.97e-01 | -0.2576 |
8394 | PIP5K1A | AEH-subject4 | Human | Endometrium | AEH | 2.02e-17 | 5.78e-01 | -0.2657 |
8394 | PIP5K1A | AEH-subject5 | Human | Endometrium | AEH | 1.02e-15 | 5.56e-01 | -0.2953 |
8394 | PIP5K1A | EEC-subject1 | Human | Endometrium | EEC | 2.96e-16 | 5.29e-01 | -0.2682 |
8394 | PIP5K1A | EEC-subject2 | Human | Endometrium | EEC | 2.58e-09 | 4.10e-01 | -0.2607 |
8394 | PIP5K1A | EEC-subject3 | Human | Endometrium | EEC | 1.46e-17 | 4.36e-01 | -0.2525 |
8394 | PIP5K1A | EEC-subject5 | Human | Endometrium | EEC | 3.16e-10 | 4.65e-01 | -0.249 |
8394 | PIP5K1A | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.61e-04 | 9.14e-02 | -0.1869 |
8394 | PIP5K1A | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.08e-04 | 6.68e-02 | -0.1875 |
8394 | PIP5K1A | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.29e-03 | 3.77e-02 | -0.1883 |
8394 | PIP5K1A | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.69e-07 | 2.94e-01 | -0.1934 |
8394 | PIP5K1A | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.77e-11 | 7.27e-02 | -0.1917 |
8394 | PIP5K1A | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.32e-09 | 1.41e-01 | -0.1916 |
8394 | PIP5K1A | LZE2T | Human | Esophagus | ESCC | 1.10e-04 | 2.54e-01 | 0.082 |
8394 | PIP5K1A | LZE4T | Human | Esophagus | ESCC | 4.16e-11 | 2.05e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00302164 | Cervix | CC | keratinocyte differentiation | 42/2311 | 139/18723 | 1.74e-08 | 1.28e-06 | 42 |
GO:00603267 | Cervix | CC | cell chemotaxis | 73/2311 | 310/18723 | 2.82e-08 | 1.96e-06 | 73 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00480417 | Cervix | CC | focal adhesion assembly | 28/2311 | 87/18723 | 9.86e-07 | 3.45e-05 | 28 |
GO:00315328 | Cervix | CC | actin cytoskeleton reorganization | 31/2311 | 107/18723 | 3.34e-06 | 8.99e-05 | 31 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:00107615 | Cervix | CC | fibroblast migration | 13/2311 | 47/18723 | 3.62e-03 | 2.31e-02 | 13 |
GO:0006909 | Cervix | CC | phagocytosis | 53/2311 | 308/18723 | 7.49e-03 | 4.01e-02 | 53 |
GO:0014065 | Cervix | CC | phosphatidylinositol 3-kinase signaling | 28/2311 | 144/18723 | 9.50e-03 | 4.72e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045106 | Liver | NAFLD | Focal adhesion | 38/1043 | 203/8465 | 5.13e-03 | 4.43e-02 | 3.57e-02 | 38 |
hsa0481011 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0513513 | Liver | NAFLD | Yersinia infection | 33/1043 | 137/8465 | 9.44e-05 | 1.94e-03 | 1.56e-03 | 33 |
hsa0451011 | Liver | NAFLD | Focal adhesion | 38/1043 | 203/8465 | 5.13e-03 | 4.43e-02 | 3.57e-02 | 38 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0451021 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513522 | Liver | Cirrhotic | Yersinia infection | 57/2530 | 137/8465 | 2.16e-03 | 9.41e-03 | 5.80e-03 | 57 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0451031 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513532 | Liver | Cirrhotic | Yersinia infection | 57/2530 | 137/8465 | 2.16e-03 | 9.41e-03 | 5.80e-03 | 57 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0513542 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0466610 | Liver | HCC | Fc gamma R-mediated phagocytosis | 58/4020 | 97/8465 | 9.65e-03 | 2.52e-02 | 1.40e-02 | 58 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0513552 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIP5K1A | SNV | Missense_Mutation | c.83C>T | p.Ser28Leu | p.S28L | Q99755 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PIP5K1A | SNV | Missense_Mutation | novel | c.680N>G | p.Tyr227Cys | p.Y227C | Q99755 | protein_coding | deleterious(0) | possibly_damaging(0.745) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
PIP5K1A | SNV | Missense_Mutation | c.1673C>T | p.Ser558Leu | p.S558L | Q99755 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIP5K1A | SNV | Missense_Mutation | rs763944215 | c.1390C>T | p.Arg464Trp | p.R464W | Q99755 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIP5K1A | SNV | Missense_Mutation | c.1163N>T | p.Ala388Val | p.A388V | Q99755 | protein_coding | deleterious(0.01) | possibly_damaging(0.641) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIP5K1A | SNV | Missense_Mutation | novel | c.118G>A | p.Glu40Lys | p.E40K | Q99755 | protein_coding | deleterious_low_confidence(0.02) | benign(0.05) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PIP5K1A | insertion | In_Frame_Ins | novel | c.594_595insCAG | p.His198_Lys199insGln | p.H198_K199insQ | Q99755 | protein_coding | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
PIP5K1A | insertion | Frame_Shift_Ins | novel | c.596_597insGGGGCAGGGGGAGCATGATGGAGACAAGATCGTGGGAC | p.Glu200GlyfsTer27 | p.E200Gfs*27 | Q99755 | protein_coding | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
PIP5K1A | deletion | Frame_Shift_Del | novel | c.1260delA | p.Ala421ProfsTer35 | p.A421Pfs*35 | Q99755 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PIP5K1A | SNV | Missense_Mutation | novel | c.835C>T | p.Pro279Ser | p.P279S | Q99755 | protein_coding | deleterious(0) | possibly_damaging(0.766) | TCGA-GH-A9DA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8394 | PIP5K1A | KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166654 |
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