Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/NUP98_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NUP98_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NUP98_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NUP98_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NUP98_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NUP98_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:004348416 | Endometrium | AEH | regulation of RNA splicing | 55/2100 | 148/18723 | 1.28e-16 | 5.49e-14 | 55 |
GO:000037515 | Endometrium | AEH | RNA splicing, via transesterification reactions | 88/2100 | 324/18723 | 1.11e-15 | 3.91e-13 | 88 |
GO:000037715 | Endometrium | AEH | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
GO:000039815 | Endometrium | AEH | mRNA splicing, via spliceosome | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
GO:004802416 | Endometrium | AEH | regulation of mRNA splicing, via spliceosome | 40/2100 | 101/18723 | 1.56e-13 | 4.27e-11 | 40 |
GO:190331110 | Endometrium | AEH | regulation of mRNA metabolic process | 77/2100 | 288/18723 | 1.69e-13 | 4.40e-11 | 77 |
GO:005068410 | Endometrium | AEH | regulation of mRNA processing | 42/2100 | 137/18723 | 6.05e-10 | 5.67e-08 | 42 |
GO:007259410 | Endometrium | AEH | establishment of protein localization to organelle | 89/2100 | 422/18723 | 2.41e-09 | 1.90e-07 | 89 |
GO:000640314 | Endometrium | AEH | RNA localization | 51/2100 | 201/18723 | 1.39e-08 | 8.98e-07 | 51 |
GO:00331209 | Endometrium | AEH | positive regulation of RNA splicing | 17/2100 | 37/18723 | 1.15e-07 | 5.49e-06 | 17 |
GO:19033137 | Endometrium | AEH | positive regulation of mRNA metabolic process | 30/2100 | 118/18723 | 1.21e-05 | 2.68e-04 | 30 |
GO:00345049 | Endometrium | AEH | protein localization to nucleus | 57/2100 | 290/18723 | 1.65e-05 | 3.42e-04 | 57 |
GO:00506579 | Endometrium | AEH | nucleic acid transport | 37/2100 | 163/18723 | 2.04e-05 | 4.09e-04 | 37 |
GO:00506589 | Endometrium | AEH | RNA transport | 37/2100 | 163/18723 | 2.04e-05 | 4.09e-04 | 37 |
GO:00512369 | Endometrium | AEH | establishment of RNA localization | 37/2100 | 166/18723 | 3.13e-05 | 5.66e-04 | 37 |
GO:00480267 | Endometrium | AEH | positive regulation of mRNA splicing, via spliceosome | 10/2100 | 22/18723 | 5.57e-05 | 8.82e-04 | 10 |
GO:00159319 | Endometrium | AEH | nucleobase-containing compound transport | 44/2100 | 222/18723 | 1.19e-04 | 1.66e-03 | 44 |
GO:000691310 | Endometrium | AEH | nucleocytoplasmic transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:005116910 | Endometrium | AEH | nuclear transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP98 | SNV | Missense_Mutation | novel | c.4906C>A | p.His1636Asn | p.H1636N | P52948 | protein_coding | tolerated(0.08) | probably_damaging(0.958) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
NUP98 | SNV | Missense_Mutation | | c.410N>G | p.Ser137Cys | p.S137C | P52948 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NUP98 | SNV | Missense_Mutation | | c.2317G>A | p.Asp773Asn | p.D773N | P52948 | protein_coding | deleterious(0) | benign(0.103) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NUP98 | SNV | Missense_Mutation | | c.4660N>T | p.His1554Tyr | p.H1554Y | P52948 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUP98 | SNV | Missense_Mutation | | c.4966G>A | p.Asp1656Asn | p.D1656N | P52948 | protein_coding | tolerated(0.3) | possibly_damaging(0.862) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NUP98 | SNV | Missense_Mutation | | c.1211G>A | p.Gly404Glu | p.G404E | P52948 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NUP98 | SNV | Missense_Mutation | novel | c.988N>A | p.Leu330Ile | p.L330I | P52948 | protein_coding | tolerated(0.16) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUP98 | SNV | Missense_Mutation | rs752419423 | c.3307N>T | p.Arg1103Cys | p.R1103C | P52948 | protein_coding | deleterious(0.02) | benign(0.398) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUP98 | SNV | Missense_Mutation | novel | c.3459G>T | p.Gln1153His | p.Q1153H | P52948 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-AR-A2LL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
NUP98 | SNV | Missense_Mutation | | c.4571N>T | p.Ser1524Leu | p.S1524L | P52948 | protein_coding | tolerated(0.07) | benign(0.202) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |