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Gene: NRBF2 |
Gene summary for NRBF2 |
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Gene information | Species | Human | Gene symbol | NRBF2 | Gene ID | 29982 |
Gene name | nuclear receptor binding factor 2 | |
Gene Alias | COPR | |
Cytomap | 10q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q96F24 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29982 | NRBF2 | LZE4T | Human | Esophagus | ESCC | 1.92e-16 | 5.26e-01 | 0.0811 |
29982 | NRBF2 | LZE7T | Human | Esophagus | ESCC | 9.78e-07 | 2.95e-01 | 0.0667 |
29982 | NRBF2 | LZE8T | Human | Esophagus | ESCC | 4.98e-14 | 2.92e-01 | 0.067 |
29982 | NRBF2 | LZE20T | Human | Esophagus | ESCC | 8.63e-07 | 2.08e-01 | 0.0662 |
29982 | NRBF2 | LZE22T | Human | Esophagus | ESCC | 1.06e-06 | 4.10e-01 | 0.068 |
29982 | NRBF2 | LZE24T | Human | Esophagus | ESCC | 5.29e-29 | 7.24e-01 | 0.0596 |
29982 | NRBF2 | LZE21T | Human | Esophagus | ESCC | 2.72e-02 | 1.73e-01 | 0.0655 |
29982 | NRBF2 | LZE6T | Human | Esophagus | ESCC | 6.71e-05 | 3.47e-01 | 0.0845 |
29982 | NRBF2 | P1T-E | Human | Esophagus | ESCC | 7.37e-10 | 6.46e-01 | 0.0875 |
29982 | NRBF2 | P2T-E | Human | Esophagus | ESCC | 8.84e-31 | 6.09e-01 | 0.1177 |
29982 | NRBF2 | P4T-E | Human | Esophagus | ESCC | 1.76e-27 | 6.24e-01 | 0.1323 |
29982 | NRBF2 | P5T-E | Human | Esophagus | ESCC | 3.42e-24 | 5.96e-01 | 0.1327 |
29982 | NRBF2 | P8T-E | Human | Esophagus | ESCC | 5.42e-21 | 4.94e-01 | 0.0889 |
29982 | NRBF2 | P9T-E | Human | Esophagus | ESCC | 2.48e-11 | 3.26e-01 | 0.1131 |
29982 | NRBF2 | P10T-E | Human | Esophagus | ESCC | 4.90e-23 | 3.66e-01 | 0.116 |
29982 | NRBF2 | P11T-E | Human | Esophagus | ESCC | 6.29e-19 | 7.89e-01 | 0.1426 |
29982 | NRBF2 | P12T-E | Human | Esophagus | ESCC | 1.48e-40 | 7.10e-01 | 0.1122 |
29982 | NRBF2 | P15T-E | Human | Esophagus | ESCC | 7.52e-29 | 5.98e-01 | 0.1149 |
29982 | NRBF2 | P16T-E | Human | Esophagus | ESCC | 6.37e-26 | 6.04e-01 | 0.1153 |
29982 | NRBF2 | P17T-E | Human | Esophagus | ESCC | 1.80e-05 | 3.65e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:003497620 | Oral cavity | OSCC | response to endoplasmic reticulum stress | 178/7305 | 256/18723 | 2.59e-23 | 6.06e-21 | 178 |
GO:0034976110 | Oral cavity | LP | response to endoplasmic reticulum stress | 133/4623 | 256/18723 | 3.84e-21 | 9.24e-19 | 133 |
GO:003497626 | Skin | AK | response to endoplasmic reticulum stress | 46/1910 | 256/18723 | 9.99e-05 | 1.33e-03 | 46 |
GO:0034976112 | Skin | cSCC | response to endoplasmic reticulum stress | 128/4864 | 256/18723 | 1.16e-16 | 1.17e-14 | 128 |
GO:0034976113 | Thyroid | PTC | response to endoplasmic reticulum stress | 161/5968 | 256/18723 | 1.14e-24 | 3.27e-22 | 161 |
GO:003497633 | Thyroid | ATC | response to endoplasmic reticulum stress | 167/6293 | 256/18723 | 2.62e-25 | 1.03e-22 | 167 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041409 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0501725 | Oral cavity | OSCC | Spinocerebellar ataxia | 86/3704 | 143/8465 | 5.21e-05 | 2.08e-04 | 1.06e-04 | 86 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa0414014 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa05017111 | Oral cavity | OSCC | Spinocerebellar ataxia | 86/3704 | 143/8465 | 5.21e-05 | 2.08e-04 | 1.06e-04 | 86 |
hsa0501429 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa0501629 | Oral cavity | LP | Huntington disease | 172/2418 | 306/8465 | 6.31e-25 | 5.25e-23 | 3.39e-23 | 172 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501726 | Oral cavity | LP | Spinocerebellar ataxia | 59/2418 | 143/8465 | 6.97e-04 | 3.46e-03 | 2.23e-03 | 59 |
hsa0414024 | Oral cavity | LP | Autophagy - animal | 55/2418 | 141/8465 | 4.54e-03 | 1.87e-02 | 1.20e-02 | 55 |
hsa0501437 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa0501637 | Oral cavity | LP | Huntington disease | 172/2418 | 306/8465 | 6.31e-25 | 5.25e-23 | 3.39e-23 | 172 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501735 | Oral cavity | LP | Spinocerebellar ataxia | 59/2418 | 143/8465 | 6.97e-04 | 3.46e-03 | 2.23e-03 | 59 |
hsa0414034 | Oral cavity | LP | Autophagy - animal | 55/2418 | 141/8465 | 4.54e-03 | 1.87e-02 | 1.20e-02 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRBF2 | SNV | Missense_Mutation | novel | c.295N>G | p.Gln99Glu | p.Q99E | Q96F24 | protein_coding | tolerated(0.07) | benign(0.397) | TCGA-AC-A3QP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
NRBF2 | SNV | Missense_Mutation | novel | c.495N>C | p.Lys165Asn | p.K165N | Q96F24 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NRBF2 | SNV | Missense_Mutation | novel | c.386A>C | p.Glu129Ala | p.E129A | Q96F24 | protein_coding | tolerated(0.12) | benign(0.017) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NRBF2 | SNV | Missense_Mutation | rs745822881 | c.82G>A | p.Glu28Lys | p.E28K | Q96F24 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NRBF2 | SNV | Missense_Mutation | c.392N>G | p.Gln131Arg | p.Q131R | Q96F24 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
NRBF2 | SNV | Missense_Mutation | c.182N>T | p.Arg61Met | p.R61M | Q96F24 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NRBF2 | SNV | Missense_Mutation | c.656N>T | p.Ala219Val | p.A219V | Q96F24 | protein_coding | deleterious(0.04) | benign(0.422) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRBF2 | SNV | Missense_Mutation | c.4N>A | p.Glu2Lys | p.E2K | Q96F24 | protein_coding | deleterious(0) | benign(0.172) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NRBF2 | SNV | Missense_Mutation | novel | c.487N>A | p.Asp163Asn | p.D163N | Q96F24 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NRBF2 | SNV | Missense_Mutation | c.686N>A | p.Ser229Asn | p.S229N | Q96F24 | protein_coding | tolerated(0.26) | benign(0.009) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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