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Gene: HKDC1 |
Gene summary for HKDC1 |
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Gene information | Species | Human | Gene symbol | HKDC1 | Gene ID | 80201 |
Gene name | hexokinase domain containing 1 | |
Gene Alias | HKDC1 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | B3KT70 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80201 | HKDC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.21e-06 | 2.16e-01 | 0.0155 |
80201 | HKDC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.63e-15 | 7.42e-01 | -0.1808 |
80201 | HKDC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.32e-23 | 7.44e-01 | -0.0811 |
80201 | HKDC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.68e-04 | 3.50e-01 | -0.1088 |
80201 | HKDC1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.24e-02 | 4.72e-01 | -0.2196 |
80201 | HKDC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.33e-06 | 4.76e-01 | -0.1207 |
80201 | HKDC1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.40e-08 | 7.27e-01 | -0.1526 |
80201 | HKDC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.15e-04 | 1.93e-01 | -0.1464 |
80201 | HKDC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.48e-02 | 1.69e-01 | -0.1001 |
80201 | HKDC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.52e-26 | 1.00e+00 | -0.059 |
80201 | HKDC1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.17e-03 | 2.13e-01 | 0.0338 |
80201 | HKDC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.42e-16 | 4.09e-01 | 0.0674 |
80201 | HKDC1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.39e-03 | 3.42e-01 | 0.0112 |
80201 | HKDC1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.92e-05 | 3.30e-01 | 0.0588 |
80201 | HKDC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.57e-13 | 5.96e-01 | 0.281 |
80201 | HKDC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.65e-36 | 9.29e-01 | 0.3859 |
80201 | HKDC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.54e-07 | 4.60e-01 | 0.2585 |
80201 | HKDC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.04e-28 | 6.62e-01 | 0.3005 |
80201 | HKDC1 | A001-C-104 | Human | Colorectum | FAP | 6.18e-04 | 2.37e-01 | 0.0184 |
80201 | HKDC1 | CRC-1-8810 | Human | Colorectum | CRC | 9.96e-07 | 3.29e-01 | 0.6257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009135 | Colorectum | AD | purine nucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0009179 | Colorectum | AD | purine ribonucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0006090 | Colorectum | AD | pyruvate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0009185 | Colorectum | AD | ribonucleoside diphosphate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0046031 | Colorectum | AD | ADP metabolic process | 41/3918 | 90/18723 | 1.37e-07 | 6.42e-06 | 41 |
GO:0006096 | Colorectum | AD | glycolytic process | 38/3918 | 81/18723 | 1.52e-07 | 6.78e-06 | 38 |
GO:0006757 | Colorectum | AD | ATP generation from ADP | 38/3918 | 82/18723 | 2.26e-07 | 9.37e-06 | 38 |
GO:0009132 | Colorectum | AD | nucleoside diphosphate metabolic process | 49/3918 | 124/18723 | 1.75e-06 | 5.31e-05 | 49 |
GO:0046939 | Colorectum | AD | nucleotide phosphorylation | 42/3918 | 101/18723 | 1.99e-06 | 5.92e-05 | 42 |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0006165 | Colorectum | AD | nucleoside diphosphate phosphorylation | 40/3918 | 99/18723 | 8.02e-06 | 1.93e-04 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051319 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa040667 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
hsa052307 | Colorectum | FAP | Central carbon metabolism in cancer | 23/1404 | 70/8465 | 6.12e-04 | 4.26e-03 | 2.59e-03 | 23 |
hsa049103 | Colorectum | FAP | Insulin signaling pathway | 36/1404 | 137/8465 | 2.51e-03 | 1.18e-02 | 7.18e-03 | 36 |
hsa000521 | Colorectum | FAP | Galactose metabolism | 12/1404 | 32/8465 | 3.61e-03 | 1.53e-02 | 9.29e-03 | 12 |
hsa012501 | Colorectum | FAP | Biosynthesis of nucleotide sugars | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa0513110 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa012008 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa049104 | Colorectum | CRC | Insulin signaling pathway | 31/1091 | 137/8465 | 1.07e-03 | 8.91e-03 | 6.03e-03 | 31 |
hsa012502 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa040668 | Colorectum | CRC | HIF-1 signaling pathway | 25/1091 | 109/8465 | 2.57e-03 | 1.75e-02 | 1.19e-02 | 25 |
hsa0513111 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa012009 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa049105 | Colorectum | CRC | Insulin signaling pathway | 31/1091 | 137/8465 | 1.07e-03 | 8.91e-03 | 6.03e-03 | 31 |
hsa012503 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa040669 | Colorectum | CRC | HIF-1 signaling pathway | 25/1091 | 109/8465 | 2.57e-03 | 1.75e-02 | 1.19e-02 | 25 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0406620 | Endometrium | AEH | HIF-1 signaling pathway | 29/1197 | 109/8465 | 4.23e-04 | 3.11e-03 | 2.27e-03 | 29 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa04066110 | Endometrium | AEH | HIF-1 signaling pathway | 29/1197 | 109/8465 | 4.23e-04 | 3.11e-03 | 2.27e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HKDC1 | SNV | Missense_Mutation | novel | c.885N>C | p.Lys295Asn | p.K295N | Q2TB90 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
HKDC1 | SNV | Missense_Mutation | c.859A>C | p.Asn287His | p.N287H | Q2TB90 | protein_coding | deleterious(0.03) | possibly_damaging(0.594) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
HKDC1 | SNV | Missense_Mutation | novel | c.720N>T | p.Glu240Asp | p.E240D | Q2TB90 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HKDC1 | SNV | Missense_Mutation | novel | c.2367C>G | p.Ile789Met | p.I789M | Q2TB90 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
HKDC1 | SNV | Missense_Mutation | novel | c.1597N>T | p.Leu533Phe | p.L533F | Q2TB90 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
HKDC1 | insertion | Nonsense_Mutation | novel | c.1795_1796insAGCTGGGACTACAGGCGCCCAGCACCACACCCGGA | p.Phe599Ter | p.F599* | Q2TB90 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
HKDC1 | insertion | Frame_Shift_Ins | novel | c.782_783insCAAGCTGCTTCCCTCAGCGAGA | p.Trp261CysfsTer23 | p.W261Cfs*23 | Q2TB90 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
HKDC1 | insertion | Nonsense_Mutation | novel | c.307_308insACTGTGCCCAGCCCCCACCTTTCAATTAATGGCATCTGTCTTGG | p.Arg103HisfsTer10 | p.R103Hfs*10 | Q2TB90 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HKDC1 | SNV | Missense_Mutation | c.1099N>A | p.Asp367Asn | p.D367N | Q2TB90 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HKDC1 | SNV | Missense_Mutation | novel | c.464N>G | p.Ser155Cys | p.S155C | Q2TB90 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | SJ000044511 | CHEMBL592124 | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | OXOPURPUREINE | OXOPURPUREINE | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | DNDI1417874 | CHEMBL1865517 | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | 2,6-DIMETHOXYQUINONE | 2,6-DIMETHOXYQUINONE | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | ALEXIDINE HYDROCHLORIDE | ALEXIDINE HYDROCHLORIDE | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | DEOXYVASICINONE | DEOXYVASICINONE | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | NSC-95397 | CHEMBL429095 | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | SJ000032153 | CHEMBL600862 | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | CHLORHEXIDINE | CHLORHEXIDINE | ||
80201 | HKDC1 | DRUGGABLE GENOME, KINASE | NSC-37642 | CHEMBL1707907 |
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