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Gene: GNAI1 |
Gene summary for GNAI1 |
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Gene information | Species | Human | Gene symbol | GNAI1 | Gene ID | 2770 |
Gene name | G protein subunit alpha i1 | |
Gene Alias | Gi | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P63096 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2770 | GNAI1 | CA_HPV_1 | Human | Cervix | CC | 1.24e-03 | -1.26e-01 | 0.0264 |
2770 | GNAI1 | CA_HPV_3 | Human | Cervix | CC | 2.37e-02 | 1.85e-01 | 0.0414 |
2770 | GNAI1 | CCI_1 | Human | Cervix | CC | 4.78e-04 | 7.87e-01 | 0.528 |
2770 | GNAI1 | CCI_3 | Human | Cervix | CC | 7.00e-05 | 6.01e-01 | 0.516 |
2770 | GNAI1 | sample3 | Human | Cervix | CC | 2.03e-05 | 2.87e-01 | 0.1387 |
2770 | GNAI1 | T3 | Human | Cervix | CC | 2.19e-08 | 3.26e-01 | 0.1389 |
2770 | GNAI1 | LZE2T | Human | Esophagus | ESCC | 3.91e-03 | 2.41e-01 | 0.082 |
2770 | GNAI1 | LZE4T | Human | Esophagus | ESCC | 1.06e-11 | 2.98e-01 | 0.0811 |
2770 | GNAI1 | LZE8T | Human | Esophagus | ESCC | 6.50e-08 | 2.19e-01 | 0.067 |
2770 | GNAI1 | LZE20T | Human | Esophagus | ESCC | 3.29e-04 | 1.84e-01 | 0.0662 |
2770 | GNAI1 | LZE22D1 | Human | Esophagus | HGIN | 4.44e-02 | -2.37e-02 | 0.0595 |
2770 | GNAI1 | LZE6T | Human | Esophagus | ESCC | 3.76e-04 | 2.64e-02 | 0.0845 |
2770 | GNAI1 | P2T-E | Human | Esophagus | ESCC | 2.40e-16 | 2.08e-01 | 0.1177 |
2770 | GNAI1 | P4T-E | Human | Esophagus | ESCC | 1.39e-05 | 2.30e-01 | 0.1323 |
2770 | GNAI1 | P5T-E | Human | Esophagus | ESCC | 3.07e-12 | 2.58e-01 | 0.1327 |
2770 | GNAI1 | P8T-E | Human | Esophagus | ESCC | 1.39e-11 | 2.02e-01 | 0.0889 |
2770 | GNAI1 | P9T-E | Human | Esophagus | ESCC | 3.49e-05 | 1.77e-01 | 0.1131 |
2770 | GNAI1 | P10T-E | Human | Esophagus | ESCC | 5.90e-24 | 1.73e-01 | 0.116 |
2770 | GNAI1 | P11T-E | Human | Esophagus | ESCC | 2.41e-11 | 7.67e-01 | 0.1426 |
2770 | GNAI1 | P15T-E | Human | Esophagus | ESCC | 2.57e-18 | 4.66e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:19043779 | Cervix | CC | positive regulation of protein localization to cell periphery | 24/2311 | 69/18723 | 1.21e-06 | 4.15e-05 | 24 |
GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:19043758 | Cervix | CC | regulation of protein localization to cell periphery | 30/2311 | 125/18723 | 2.28e-04 | 2.56e-03 | 30 |
GO:00705074 | Cervix | CC | regulation of microtubule cytoskeleton organization | 32/2311 | 148/18723 | 1.02e-03 | 8.51e-03 | 32 |
GO:00973059 | Cervix | CC | response to alcohol | 46/2311 | 253/18723 | 4.40e-03 | 2.69e-02 | 46 |
GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
GO:190437518 | Esophagus | HGIN | regulation of protein localization to cell periphery | 32/2587 | 125/18723 | 3.23e-04 | 5.39e-03 | 32 |
GO:00070527 | Esophagus | HGIN | mitotic spindle organization | 31/2587 | 120/18723 | 3.35e-04 | 5.50e-03 | 31 |
GO:19028507 | Esophagus | HGIN | microtubule cytoskeleton organization involved in mitosis | 36/2587 | 147/18723 | 3.61e-04 | 5.68e-03 | 36 |
GO:00070518 | Esophagus | HGIN | spindle organization | 42/2587 | 184/18723 | 6.07e-04 | 8.49e-03 | 42 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:004343420 | Esophagus | HGIN | response to peptide hormone | 79/2587 | 414/18723 | 1.60e-03 | 1.79e-02 | 79 |
GO:190437718 | Esophagus | HGIN | positive regulation of protein localization to cell periphery | 18/2587 | 69/18723 | 4.94e-03 | 4.18e-02 | 18 |
GO:00902245 | Esophagus | HGIN | regulation of spindle organization | 12/2587 | 39/18723 | 4.97e-03 | 4.18e-02 | 12 |
GO:00602365 | Esophagus | HGIN | regulation of mitotic spindle organization | 11/2587 | 35/18723 | 5.89e-03 | 4.78e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04723112 | Esophagus | HGIN | Retrograde endocannabinoid signaling | 36/1383 | 148/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 36 |
hsa05163113 | Esophagus | HGIN | Human cytomegalovirus infection | 51/1383 | 225/8465 | 7.67e-03 | 4.63e-02 | 3.68e-02 | 51 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa05163210 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0407116 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa0514525 | Esophagus | ESCC | Toxoplasmosis | 76/4205 | 112/8465 | 6.83e-05 | 2.90e-04 | 1.48e-04 | 76 |
hsa049268 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa051425 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa051339 | Esophagus | ESCC | Pertussis | 48/4205 | 76/8465 | 1.21e-02 | 2.77e-02 | 1.42e-02 | 48 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0516338 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0407117 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa05145111 | Esophagus | ESCC | Toxoplasmosis | 76/4205 | 112/8465 | 6.83e-05 | 2.90e-04 | 1.48e-04 | 76 |
hsa0492616 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa0514213 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNAI1 | SNV | Missense_Mutation | rs142908338 | c.313C>T | p.Arg105Cys | p.R105C | P63096 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
GNAI1 | SNV | Missense_Mutation | novel | c.1051T>G | p.Cys351Gly | p.C351G | P63096 | protein_coding | deleterious(0.01) | possibly_damaging(0.468) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAI1 | deletion | Frame_Shift_Del | novel | c.908delN | p.Gln304AsnfsTer36 | p.Q304Nfs*36 | P63096 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
GNAI1 | SNV | Missense_Mutation | c.601N>A | p.Val201Met | p.V201M | P63096 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GNAI1 | SNV | Missense_Mutation | novel | c.190N>A | p.Glu64Lys | p.E64K | P63096 | protein_coding | deleterious(0.03) | benign(0.116) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GNAI1 | SNV | Missense_Mutation | novel | c.752N>G | p.Asp251Gly | p.D251G | P63096 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GNAI1 | SNV | Missense_Mutation | rs758691743 | c.314N>A | p.Arg105His | p.R105H | P63096 | protein_coding | tolerated(0.07) | possibly_damaging(0.621) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GNAI1 | SNV | Missense_Mutation | c.659N>T | p.Ala220Val | p.A220V | P63096 | protein_coding | deleterious(0.01) | benign(0.191) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
GNAI1 | SNV | Missense_Mutation | novel | c.658G>A | p.Ala220Thr | p.A220T | P63096 | protein_coding | tolerated(0.05) | possibly_damaging(0.886) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GNAI1 | insertion | Frame_Shift_Ins | novel | c.720_720+1insA | p.Asn241LysfsTer5 | p.N241Kfs*5 | P63096 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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