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Gene: CHCHD10 |
Gene summary for CHCHD10 |
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Gene information | Species | Human | Gene symbol | CHCHD10 | Gene ID | 400916 |
Gene name | coiled-coil-helix-coiled-coil-helix domain containing 10 | |
Gene Alias | C22orf16 | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | B5MBW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
400916 | CHCHD10 | CA_HPV_1 | Human | Cervix | CC | 9.81e-07 | 7.06e-02 | 0.0264 |
400916 | CHCHD10 | CCI_1 | Human | Cervix | CC | 2.17e-08 | -6.65e-01 | 0.528 |
400916 | CHCHD10 | CCI_3 | Human | Cervix | CC | 2.01e-06 | -5.70e-01 | 0.516 |
400916 | CHCHD10 | CCII_1 | Human | Cervix | CC | 2.75e-22 | -7.06e-01 | 0.3249 |
400916 | CHCHD10 | sample1 | Human | Cervix | CC | 5.48e-09 | 4.31e-01 | 0.0959 |
400916 | CHCHD10 | L1 | Human | Cervix | CC | 3.16e-11 | -4.45e-01 | 0.0802 |
400916 | CHCHD10 | T1 | Human | Cervix | CC | 9.13e-05 | 2.93e-01 | 0.0918 |
400916 | CHCHD10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.86e-26 | 1.06e+00 | -0.1808 |
400916 | CHCHD10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.49e-09 | 7.25e-01 | -0.0811 |
400916 | CHCHD10 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.55e-06 | 4.68e-01 | -0.1088 |
400916 | CHCHD10 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.05e-41 | 1.18e+00 | -0.1954 |
400916 | CHCHD10 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.42e-07 | 1.07e+00 | -0.2602 |
400916 | CHCHD10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.20e-23 | 1.07e+00 | -0.1207 |
400916 | CHCHD10 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.91e-11 | 8.33e-01 | -0.1526 |
400916 | CHCHD10 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.29e-38 | 9.67e-01 | -0.1464 |
400916 | CHCHD10 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.06e-20 | 7.19e-01 | -0.1001 |
400916 | CHCHD10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.04e-16 | 8.04e-01 | -0.059 |
400916 | CHCHD10 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.21e-10 | 9.43e-01 | -0.1706 |
400916 | CHCHD10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.91e-07 | 8.30e-01 | -0.2061 |
400916 | CHCHD10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.52e-03 | 6.91e-01 | -0.1462 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:000611910 | Cervix | CC | oxidative phosphorylation | 55/2311 | 141/18723 | 7.12e-16 | 1.42e-12 | 55 |
GO:00090609 | Cervix | CC | aerobic respiration | 60/2311 | 189/18723 | 1.59e-12 | 6.36e-10 | 60 |
GO:00453339 | Cervix | CC | cellular respiration | 66/2311 | 230/18723 | 2.07e-11 | 5.39e-09 | 66 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:00325077 | Cervix | CC | maintenance of protein location in cell | 21/2311 | 65/18723 | 2.03e-05 | 3.71e-04 | 21 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:00108218 | Cervix | CC | regulation of mitochondrion organization | 34/2311 | 144/18723 | 1.27e-04 | 1.58e-03 | 34 |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00725955 | Cervix | CC | maintenance of protein localization in organelle | 14/2311 | 42/18723 | 3.32e-04 | 3.49e-03 | 14 |
GO:00086379 | Cervix | CC | apoptotic mitochondrial changes | 25/2311 | 107/18723 | 1.11e-03 | 9.14e-03 | 25 |
GO:00108224 | Cervix | CC | positive regulation of mitochondrion organization | 19/2311 | 74/18723 | 1.30e-03 | 1.03e-02 | 19 |
GO:00514571 | Cervix | CC | maintenance of protein location in nucleus | 8/2311 | 23/18723 | 4.70e-03 | 2.82e-02 | 8 |
GO:00070074 | Cervix | CC | inner mitochondrial membrane organization | 11/2311 | 38/18723 | 4.94e-03 | 2.95e-02 | 11 |
GO:00343316 | Cervix | CC | cell junction maintenance | 10/2311 | 35/18723 | 7.99e-03 | 4.18e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501461 | Stomach | CAG | Amyotrophic lateral sclerosis | 46/368 | 364/8465 | 3.68e-11 | 1.06e-09 | 8.52e-10 | 46 |
hsa0501471 | Stomach | CAG | Amyotrophic lateral sclerosis | 46/368 | 364/8465 | 3.68e-11 | 1.06e-09 | 8.52e-10 | 46 |
hsa0501410 | Stomach | SIM | Amyotrophic lateral sclerosis | 53/465 | 364/8465 | 3.68e-11 | 1.02e-09 | 8.16e-10 | 53 |
hsa0501411 | Stomach | SIM | Amyotrophic lateral sclerosis | 53/465 | 364/8465 | 3.68e-11 | 1.02e-09 | 8.16e-10 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHCHD10 | SNV | Missense_Mutation | rs562212051 | c.328N>A | p.Ala110Thr | p.A110T | protein_coding | tolerated(0.41) | benign(0.307) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CHCHD10 | SNV | Missense_Mutation | novel | c.402N>T | p.Glu134Asp | p.E134D | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHCHD10 | SNV | Missense_Mutation | novel | c.173N>T | p.Gly58Val | p.G58V | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CHCHD10 | SNV | Missense_Mutation | c.427N>A | p.His143Asn | p.H143N | protein_coding | tolerated(1) | benign(0.003) | TCGA-66-2734-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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