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Gene: CDKN1B |
Gene summary for CDKN1B |
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Gene information | Species | Human | Gene symbol | CDKN1B | Gene ID | 1027 |
Gene name | cyclin dependent kinase inhibitor 1B | |
Gene Alias | CDKN4 | |
Cytomap | 12p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P46527 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1027 | CDKN1B | LZE2T | Human | Esophagus | ESCC | 9.39e-03 | 2.31e-01 | 0.082 |
1027 | CDKN1B | LZE4T | Human | Esophagus | ESCC | 9.07e-16 | 4.61e-01 | 0.0811 |
1027 | CDKN1B | LZE7T | Human | Esophagus | ESCC | 4.70e-11 | 7.82e-01 | 0.0667 |
1027 | CDKN1B | LZE8T | Human | Esophagus | ESCC | 3.05e-12 | 5.75e-01 | 0.067 |
1027 | CDKN1B | LZE22D1 | Human | Esophagus | HGIN | 2.41e-04 | 2.94e-01 | 0.0595 |
1027 | CDKN1B | LZE22T | Human | Esophagus | ESCC | 7.98e-05 | 5.64e-01 | 0.068 |
1027 | CDKN1B | LZE24T | Human | Esophagus | ESCC | 1.57e-22 | 6.61e-01 | 0.0596 |
1027 | CDKN1B | LZE21T | Human | Esophagus | ESCC | 3.95e-08 | 6.11e-01 | 0.0655 |
1027 | CDKN1B | LZE6T | Human | Esophagus | ESCC | 5.16e-05 | 4.48e-01 | 0.0845 |
1027 | CDKN1B | P1T-E | Human | Esophagus | ESCC | 4.74e-07 | 6.06e-01 | 0.0875 |
1027 | CDKN1B | P2T-E | Human | Esophagus | ESCC | 1.81e-75 | 1.55e+00 | 0.1177 |
1027 | CDKN1B | P4T-E | Human | Esophagus | ESCC | 1.26e-63 | 1.67e+00 | 0.1323 |
1027 | CDKN1B | P5T-E | Human | Esophagus | ESCC | 9.76e-22 | 3.36e-01 | 0.1327 |
1027 | CDKN1B | P8T-E | Human | Esophagus | ESCC | 3.58e-29 | 5.08e-01 | 0.0889 |
1027 | CDKN1B | P9T-E | Human | Esophagus | ESCC | 2.31e-22 | 4.41e-01 | 0.1131 |
1027 | CDKN1B | P10T-E | Human | Esophagus | ESCC | 3.72e-33 | 6.29e-01 | 0.116 |
1027 | CDKN1B | P11T-E | Human | Esophagus | ESCC | 8.69e-15 | 5.32e-01 | 0.1426 |
1027 | CDKN1B | P12T-E | Human | Esophagus | ESCC | 6.02e-73 | 1.51e+00 | 0.1122 |
1027 | CDKN1B | P15T-E | Human | Esophagus | ESCC | 2.80e-27 | 8.33e-01 | 0.1149 |
1027 | CDKN1B | P16T-E | Human | Esophagus | ESCC | 1.63e-113 | 2.68e+00 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
GO:004573227 | Esophagus | HGIN | positive regulation of protein catabolic process | 69/2587 | 231/18723 | 1.66e-10 | 1.64e-08 | 69 |
GO:007233127 | Esophagus | HGIN | signal transduction by p53 class mediator | 49/2587 | 163/18723 | 5.71e-08 | 3.06e-06 | 49 |
GO:003133425 | Esophagus | HGIN | positive regulation of protein-containing complex assembly | 61/2587 | 237/18723 | 7.10e-07 | 3.00e-05 | 61 |
GO:004325427 | Esophagus | HGIN | regulation of protein-containing complex assembly | 94/2587 | 428/18723 | 2.39e-06 | 8.55e-05 | 94 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:003033020 | Esophagus | HGIN | DNA damage response, signal transduction by p53 class mediator | 24/2587 | 72/18723 | 2.03e-05 | 5.43e-04 | 24 |
GO:007048220 | Esophagus | HGIN | response to oxygen levels | 76/2587 | 347/18723 | 2.36e-05 | 6.25e-04 | 76 |
GO:00447729 | Esophagus | HGIN | mitotic cell cycle phase transition | 89/2587 | 424/18723 | 2.80e-05 | 7.21e-04 | 89 |
GO:005125826 | Esophagus | HGIN | protein polymerization | 66/2587 | 297/18723 | 4.96e-05 | 1.19e-03 | 66 |
GO:003629320 | Esophagus | HGIN | response to decreased oxygen levels | 70/2587 | 322/18723 | 6.23e-05 | 1.44e-03 | 70 |
GO:000166620 | Esophagus | HGIN | response to hypoxia | 67/2587 | 307/18723 | 7.82e-05 | 1.75e-03 | 67 |
GO:19019906 | Esophagus | HGIN | regulation of mitotic cell cycle phase transition | 65/2587 | 299/18723 | 1.12e-04 | 2.36e-03 | 65 |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:004873225 | Esophagus | HGIN | gland development | 88/2587 | 436/18723 | 1.34e-04 | 2.71e-03 | 88 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:190290327 | Esophagus | HGIN | regulation of supramolecular fiber organization | 79/2587 | 383/18723 | 1.40e-04 | 2.81e-03 | 79 |
GO:20000456 | Esophagus | HGIN | regulation of G1/S transition of mitotic cell cycle | 36/2587 | 142/18723 | 1.74e-04 | 3.35e-03 | 36 |
GO:004232620 | Esophagus | HGIN | negative regulation of phosphorylation | 78/2587 | 385/18723 | 2.77e-04 | 4.77e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0522018 | Oral cavity | OSCC | Chronic myeloid leukemia | 56/3704 | 76/8465 | 1.04e-07 | 7.43e-07 | 3.78e-07 | 56 |
hsa049339 | Oral cavity | OSCC | AGE-RAGE signaling pathway in diabetic complications | 69/3704 | 100/8465 | 2.61e-07 | 1.65e-06 | 8.41e-07 | 69 |
hsa051628 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa040688 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
hsa0521510 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
hsa015226 | Oral cavity | OSCC | Endocrine resistance | 63/3704 | 98/8465 | 3.09e-05 | 1.31e-04 | 6.67e-05 | 63 |
hsa0406627 | Oral cavity | OSCC | HIF-1 signaling pathway | 68/3704 | 109/8465 | 6.30e-05 | 2.48e-04 | 1.26e-04 | 68 |
hsa0401216 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa05169113 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0522215 | Oral cavity | OSCC | Small cell lung cancer | 66/3704 | 92/8465 | 4.43e-08 | 3.38e-07 | 1.72e-07 | 66 |
hsa0522019 | Oral cavity | OSCC | Chronic myeloid leukemia | 56/3704 | 76/8465 | 1.04e-07 | 7.43e-07 | 3.78e-07 | 56 |
hsa0493316 | Oral cavity | OSCC | AGE-RAGE signaling pathway in diabetic complications | 69/3704 | 100/8465 | 2.61e-07 | 1.65e-06 | 8.41e-07 | 69 |
hsa0516212 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0406813 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
hsa0521515 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDKN1B | SNV | Missense_Mutation | novel | c.548C>T | p.Ser183Phe | p.S183F | P46527 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-BH-A0C3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
CDKN1B | insertion | Nonsense_Mutation | novel | c.460_461insTACAATCCCGGGAAAGAACAGAAAAGTAGAAAGG | p.Arg154LeufsTer10 | p.R154Lfs*10 | P46527 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CDKN1B | insertion | Frame_Shift_Ins | novel | c.373_374insC | p.Glu126Ter | p.E126* | P46527 | protein_coding | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
CDKN1B | deletion | Frame_Shift_Del | c.402delN | p.Thr135LeufsTer10 | p.T135Lfs*10 | P46527 | protein_coding | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |||
CDKN1B | insertion | Frame_Shift_Ins | novel | c.233_234insGG | p.Val79GlyfsTer41 | p.V79Gfs*41 | P46527 | protein_coding | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
CDKN1B | insertion | Frame_Shift_Ins | novel | c.164_165dupCG | p.Ser56ArgfsTer16 | p.S56Rfs*16 | P46527 | protein_coding | TCGA-BH-A1FJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CDKN1B | SNV | Missense_Mutation | novel | c.436G>A | p.Glu146Lys | p.E146K | P46527 | protein_coding | deleterious(0.02) | benign(0.211) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
CDKN1B | SNV | Missense_Mutation | c.215N>A | p.Gly72Asp | p.G72D | P46527 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDKN1B | deletion | Frame_Shift_Del | c.410delC | p.Pro137ArgfsTer8 | p.P137Rfs*8 | P46527 | protein_coding | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
CDKN1B | insertion | Frame_Shift_Ins | novel | c.212_213insG | p.Lys73GlnfsTer52 | p.K73Qfs*52 | P46527 | protein_coding | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | TCDD | 12883080 | ||
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | ANTIESTROGEN | 10908655 | ||
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | ERYTHROPOIETIN | EPOETIN BETA | 11023508 | |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | METHOTREXATE | METHOTREXATE | 14512390 | |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | PROGESTIN | PROGESTERONE | 11590147 | |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | DOXORUBICIN | DOXORUBICIN | 12576455 | |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | IMMUNOSUPPRESSIVE | 17015702 | ||
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | PD-98059 | CHEMBL35482 | 11031257 | |
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | AMINOGLYCOSIDES | 10900094 | ||
1027 | CDKN1B | DRUG RESISTANCE, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE, KINASE | ATRA | TRETINOIN | 10837916 |
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