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Gene: ACTR1A |
Gene summary for ACTR1A |
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Gene information | Species | Human | Gene symbol | ACTR1A | Gene ID | 10121 |
Gene name | actin related protein 1A | |
Gene Alias | ARP1 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P61163 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10121 | ACTR1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-03 | 2.93e-01 | -0.1808 |
10121 | ACTR1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.39e-03 | 2.00e-01 | -0.0811 |
10121 | ACTR1A | HTA11_347_2000001011 | Human | Colorectum | AD | 7.96e-05 | 2.45e-01 | -0.1954 |
10121 | ACTR1A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.52e-02 | 2.36e-01 | -0.1464 |
10121 | ACTR1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.44e-05 | 3.12e-01 | -0.059 |
10121 | ACTR1A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.59e-03 | 6.79e-01 | 0.3487 |
10121 | ACTR1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.86e-03 | 2.63e-01 | 0.281 |
10121 | ACTR1A | LZE4T | Human | Esophagus | ESCC | 3.31e-10 | 3.31e-01 | 0.0811 |
10121 | ACTR1A | LZE5T | Human | Esophagus | ESCC | 2.13e-09 | 4.22e-01 | 0.0514 |
10121 | ACTR1A | LZE7T | Human | Esophagus | ESCC | 1.61e-04 | 4.28e-01 | 0.0667 |
10121 | ACTR1A | LZE8T | Human | Esophagus | ESCC | 6.68e-07 | 3.03e-01 | 0.067 |
10121 | ACTR1A | LZE20T | Human | Esophagus | ESCC | 1.10e-02 | 2.97e-01 | 0.0662 |
10121 | ACTR1A | LZE22T | Human | Esophagus | ESCC | 4.21e-04 | 2.96e-01 | 0.068 |
10121 | ACTR1A | LZE24T | Human | Esophagus | ESCC | 7.71e-30 | 8.14e-01 | 0.0596 |
10121 | ACTR1A | LZE6T | Human | Esophagus | ESCC | 8.55e-11 | 5.22e-01 | 0.0845 |
10121 | ACTR1A | P1T-E | Human | Esophagus | ESCC | 1.78e-05 | 4.02e-01 | 0.0875 |
10121 | ACTR1A | P2T-E | Human | Esophagus | ESCC | 8.41e-39 | 7.55e-01 | 0.1177 |
10121 | ACTR1A | P4T-E | Human | Esophagus | ESCC | 1.99e-28 | 8.61e-01 | 0.1323 |
10121 | ACTR1A | P5T-E | Human | Esophagus | ESCC | 5.89e-26 | 6.56e-01 | 0.1327 |
10121 | ACTR1A | P8T-E | Human | Esophagus | ESCC | 1.05e-20 | 4.22e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501632 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0513230 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa05132114 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa0501429 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa0501629 | Oral cavity | LP | Huntington disease | 172/2418 | 306/8465 | 6.31e-25 | 5.25e-23 | 3.39e-23 | 172 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa05132210 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR1A | SNV | Missense_Mutation | c.1109C>T | p.Ser370Phe | p.S370F | P61163 | protein_coding | deleterious(0.01) | benign(0.218) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTR1A | SNV | Missense_Mutation | c.806N>A | p.Gly269Glu | p.G269E | P61163 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ACTR1A | SNV | Missense_Mutation | c.53N>G | p.Ser18Cys | p.S18C | P61163 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-C8-A26V-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | CR | |
ACTR1A | insertion | Nonsense_Mutation | novel | c.211_212insACCTATGTCTTTTAGAATTCAAAGCCTGTGCTCATTAACTTCTT | p.Ile71AsnfsTer13 | p.I71Nfs*13 | P61163 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ACTR1A | SNV | Missense_Mutation | c.655N>C | p.Glu219Gln | p.E219Q | P61163 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ACTR1A | SNV | Missense_Mutation | c.514N>A | p.Glu172Lys | p.E172K | P61163 | protein_coding | deleterious(0.01) | benign(0.167) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ACTR1A | SNV | Missense_Mutation | rs764802984 | c.238N>A | p.Val80Ile | p.V80I | P61163 | protein_coding | tolerated(0.18) | benign(0.026) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACTR1A | SNV | Missense_Mutation | c.1099N>A | p.Gly367Ser | p.G367S | P61163 | protein_coding | deleterious(0.04) | probably_damaging(0.927) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTR1A | SNV | Missense_Mutation | novel | c.842N>G | p.Phe281Cys | p.F281C | P61163 | protein_coding | tolerated(0.09) | possibly_damaging(0.762) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTR1A | SNV | Missense_Mutation | novel | c.106N>T | p.Pro36Ser | p.P36S | P61163 | protein_coding | tolerated(0.09) | benign(0.018) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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