Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/NDUFV2_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/NDUFV2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/NDUFV2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NDUFV2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/NDUFV2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NDUFV2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NDUFV2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NDUFV2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NDUFV2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NDUFV2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:00061199 | Breast | Precancer | oxidative phosphorylation | 53/1080 | 141/18723 | 1.15e-29 | 2.04e-26 | 53 |
GO:00090608 | Breast | Precancer | aerobic respiration | 58/1080 | 189/18723 | 5.69e-27 | 7.62e-24 | 58 |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00453338 | Breast | Precancer | cellular respiration | 59/1080 | 230/18723 | 5.97e-23 | 5.32e-20 | 59 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:00196468 | Breast | Precancer | aerobic electron transport chain | 34/1080 | 87/18723 | 3.95e-20 | 2.64e-17 | 34 |
GO:00427738 | Breast | Precancer | ATP synthesis coupled electron transport | 35/1080 | 95/18723 | 1.08e-19 | 5.76e-17 | 35 |
GO:00427758 | Breast | Precancer | mitochondrial ATP synthesis coupled electron transport | 35/1080 | 95/18723 | 1.08e-19 | 5.76e-17 | 35 |
GO:00229048 | Breast | Precancer | respiratory electron transport chain | 35/1080 | 114/18723 | 8.51e-17 | 3.26e-14 | 35 |
GO:00229008 | Breast | Precancer | electron transport chain | 42/1080 | 175/18723 | 1.37e-15 | 4.59e-13 | 42 |
GO:00061208 | Breast | Precancer | mitochondrial electron transport, NADH to ubiquinone | 19/1080 | 51/18723 | 2.05e-11 | 2.49e-09 | 19 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
GO:004603414 | Breast | IDC | ATP metabolic process | 85/1434 | 277/18723 | 6.42e-30 | 1.82e-26 | 85 |
GO:000611913 | Breast | IDC | oxidative phosphorylation | 56/1434 | 141/18723 | 1.87e-26 | 3.53e-23 | 56 |
GO:000906013 | Breast | IDC | aerobic respiration | 61/1434 | 189/18723 | 4.42e-23 | 6.27e-20 | 61 |
GO:000609113 | Breast | IDC | generation of precursor metabolites and energy | 103/1434 | 490/18723 | 1.53e-21 | 1.74e-18 | 103 |
GO:004533313 | Breast | IDC | cellular respiration | 62/1434 | 230/18723 | 5.98e-19 | 4.25e-16 | 62 |
GO:004277313 | Breast | IDC | ATP synthesis coupled electron transport | 38/1434 | 95/18723 | 1.65e-18 | 9.36e-16 | 38 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520891 | Stomach | WIM | Chemical carcinogenesis - reactive oxygen species | 30/284 | 223/8465 | 5.54e-11 | 2.59e-09 | 2.06e-09 | 30 |
hsa0502091 | Stomach | WIM | Prion disease | 33/284 | 273/8465 | 1.06e-10 | 4.25e-09 | 3.39e-09 | 33 |
hsa0501491 | Stomach | WIM | Amyotrophic lateral sclerosis | 36/284 | 364/8465 | 4.01e-09 | 1.25e-07 | 9.94e-08 | 36 |
hsa0541591 | Stomach | WIM | Diabetic cardiomyopathy | 24/284 | 203/8465 | 6.66e-08 | 1.55e-06 | 1.24e-06 | 24 |
hsa0019091 | Stomach | WIM | Oxidative phosphorylation | 19/284 | 134/8465 | 9.21e-08 | 1.98e-06 | 1.58e-06 | 19 |
hsa0501691 | Stomach | WIM | Huntington disease | 30/284 | 306/8465 | 1.07e-07 | 2.14e-06 | 1.71e-06 | 30 |
hsa0502291 | Stomach | WIM | Pathways of neurodegeneration - multiple diseases | 38/284 | 476/8465 | 4.54e-07 | 7.94e-06 | 6.33e-06 | 38 |
hsa0471491 | Stomach | WIM | Thermogenesis | 22/284 | 232/8465 | 9.95e-06 | 1.33e-04 | 1.06e-04 | 22 |
hsa0501091 | Stomach | WIM | Alzheimer disease | 30/284 | 384/8465 | 1.25e-05 | 1.59e-04 | 1.27e-04 | 30 |
hsa047239 | Stomach | WIM | Retrograde endocannabinoid signaling | 12/284 | 148/8465 | 4.04e-03 | 2.90e-02 | 2.31e-02 | 12 |
hsa05208101 | Stomach | SIM | Chemical carcinogenesis - reactive oxygen species | 48/465 | 223/8465 | 8.30e-17 | 8.41e-15 | 6.75e-15 | 48 |
hsa0501210 | Stomach | SIM | Parkinson disease | 52/465 | 266/8465 | 3.04e-16 | 2.31e-14 | 1.86e-14 | 52 |
hsa0493210 | Stomach | SIM | Non-alcoholic fatty liver disease | 38/465 | 155/8465 | 1.79e-15 | 1.09e-13 | 8.74e-14 | 38 |
hsa0502010 | Stomach | SIM | Prion disease | 50/465 | 273/8465 | 1.83e-14 | 9.28e-13 | 7.45e-13 | 50 |
hsa0019010 | Stomach | SIM | Oxidative phosphorylation | 32/465 | 134/8465 | 7.12e-13 | 3.09e-11 | 2.49e-11 | 32 |
hsa0501610 | Stomach | SIM | Huntington disease | 50/465 | 306/8465 | 1.79e-12 | 6.79e-11 | 5.45e-11 | 50 |
hsa0541510 | Stomach | SIM | Diabetic cardiomyopathy | 38/465 | 203/8465 | 1.53e-11 | 4.64e-10 | 3.72e-10 | 38 |
hsa0501410 | Stomach | SIM | Amyotrophic lateral sclerosis | 53/465 | 364/8465 | 3.68e-11 | 1.02e-09 | 8.16e-10 | 53 |
hsa0471410 | Stomach | SIM | Thermogenesis | 36/465 | 232/8465 | 1.13e-08 | 2.85e-07 | 2.29e-07 | 36 |
hsa0502210 | Stomach | SIM | Pathways of neurodegeneration - multiple diseases | 55/465 | 476/8465 | 8.30e-08 | 1.66e-06 | 1.34e-06 | 55 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFV2 | SNV | Missense_Mutation | | c.743N>T | p.Gly248Val | p.G248V | P19404 | protein_coding | deleterious(0.01) | benign(0.197) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NDUFV2 | SNV | Missense_Mutation | | c.391N>G | p.His131Asp | p.H131D | P19404 | protein_coding | deleterious(0.01) | possibly_damaging(0.883) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NDUFV2 | SNV | Missense_Mutation | | c.647N>A | p.Pro216Gln | p.P216Q | P19404 | protein_coding | deleterious(0.02) | benign(0.091) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFV2 | SNV | Missense_Mutation | | c.691N>G | p.Leu231Val | p.L231V | P19404 | protein_coding | tolerated(0.12) | benign(0.067) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NDUFV2 | SNV | Missense_Mutation | novel | c.697N>C | p.Ser233Pro | p.S233P | P19404 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-CI-6620-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Ancillary | leucovorin | PD |
NDUFV2 | SNV | Missense_Mutation | novel | c.193N>A | p.Ala65Thr | p.A65T | P19404 | protein_coding | tolerated(0.13) | benign(0.196) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFV2 | SNV | Missense_Mutation | novel | c.583N>T | p.Asp195Tyr | p.D195Y | P19404 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
NDUFV2 | SNV | Missense_Mutation | novel | c.163T>C | p.Phe55Leu | p.F55L | P19404 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFV2 | SNV | Missense_Mutation | novel | c.725N>A | p.Gly242Glu | p.G242E | P19404 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFV2 | SNV | Missense_Mutation | novel | c.194N>T | p.Ala65Val | p.A65V | P19404 | protein_coding | tolerated(0.09) | benign(0.05) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |